SAAP 148

Cat. No.: HY-P10233: FAQs
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SAAP 148 is an antimicrobial and antibiofilm agent, and exhibits inhibitory efficacy against antibiotic-resistant pathogens, with LC₅₀ of 0.8-12.8 μM.

For research use only. We do not sell to patients.

SAAP 148 Chemical Structure

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Other Forms of SAAP 148:

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Description

SAAP 148 is an antimicrobial and antibiofilm agent, and exhibits inhibitory efficacy against antibiotic-resistant pathogens, with LC₅₀ of 0.8-12.8 μM^[1].

In Vitro

SAAP 148 inhibits S. aureus and P. aeruginosa with LC₉₉ of 1.6, 1.6, 12.8 and 12.8 μM, in PBS and in plasma, respectively^[1].
SAAP-148 (0.4-3.2 μM, 2 h) interacts and permeabilizes the bacterial membrane, resulting the bacterial death^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SAAP-148 (30 mg of 0.125-2% w/w ointment, apply on skin, single dose) eradicates Methicillin (HY-121544)-resistant S. aureus (MRSA) and A. baumannii from the skin, attenuates abraded skin infection in mice model, without toxicity (2000 mg/kg)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Abraded skin infection in C57BL/6J mice model^[1]
Dosage:	30 mg of 0.125-2% w/w ointment
Administration:	apply on skin, single dose
Result:	Eradicated MRSA and A. baumannii, attenuated abraded skin infection

Molecular Weight

3267.06

Formula

C₁₅₇H₂₆₁N₄₉O₂₇

Sequence

Ac-Leu-Lys-Arg-Val-Trp-Lys-Arg-Val-Phe-Lys-Leu-Leu-Lys-Arg-Tyr-Trp-Arg-Gln-Leu-Lys-Lys-Pro-Val-Arg-NH2

Sequence Shortening

Ac-LKRVWKRVFKLLKRYWRQLKKPVR-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. de Breij A, et al., The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms. Sci Transl Med. 2018 Jan 10;10(423):eaan4044. [Content Brief]

SAAP 148 Related Classifications

Infection

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAAP 148SAAP148SAAP-148BacterialC57BL/6J miceS. aureusP. aeruginosaA. baumanniiInhibitorinhibitorinhibit

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