2. Immunology/Inflammation
  3. Tim3
  4. Sabatolimab

Sabatolimab  (Synonyms: MBG453)

Cat. No.: HY-P99044 Purity: ≥95.0%
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Sabatolimab (MBG453) is a high-affinity, humanized, IgG4 (S228P) antibody targeting TIM-3, an inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab is a potential immunosuppression agent that can target TIM-3 on immune and myeloid cells.

For research use only. We do not sell to patients.

CAS No. : 2252262-24-9

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1 mg USD 220 In-stock
5 mg USD 650 In-stock
10 mg USD 1100 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Sabatolimab Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Sabatolimab

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Sabatolimab (MBG453) is a high-affinity, humanized, IgG4 (S228P) antibody targeting TIM-3, an inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab is a potential immunosuppression agent that can target TIM-3 on immune and myeloid cells[1].

Isotype

Human IgG4 (S228P) kappa
Recommend Isotype Controls
Species

Humanized
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Sabatolimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Loaded TIM-3/HAVCR2 Protein, Human (Biotinylated, HEK293, His-Avi,HY-P78217) on AHC2 biosensor, can bind Sabatolimab with an affinity constant of 8.541E-11 M as determined in BLI assay.
Purity & Documentation

Purity: ≥95.0%

SDS (251 KB)

COA (231 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Sabatolimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sabatolimab2252262-24-9MBG453MBG 453MBG-453Tim3T-Cell Immunoglobulin and Mucin Containing Protein-3CD366humanizedIgG4S228PantibodyTIM-3adaptiveinnate immuneimmunosuppression agentmyeloid cellsInhibitorinhibitorinhibit

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