2. Immunology/Inflammation Apoptosis NF-κB
  3. NO Synthase TNF Receptor NF-κB COX Interleukin Related
  4. Sabialimon P

Sabialimon P (compound 16) is a NO release inhibitor (IC50=18.12 μM) with anti-inflammatory activity. Sabialimon P significantly reduces the secretion of TNF-α, iNOS, IL-6 and NF-κB and inhibits the expression of COX-2 and NF-κB/p65 in RAW264.7 cells induced by LPS (HY-D1056).

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Sabialimon P Chemical Structure

Sabialimon P Chemical Structure

CAS No. : 2267333-96-8

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Sabialimon P Related Antibodies

Top Publications Citing Use of Products

View All NO Synthase Isoform Specific Products:

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nNOS iNOS eNOS

View All TNF Receptor Isoform Specific Products:

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

View All NF-κB Isoform Specific Products:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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COX COX-1 COX-2 COX-3

View All Interleukin Related Isoform Specific Products:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

Sabialimon P (compound 16) is a NO release inhibitor (IC50=18.12 μM) with anti-inflammatory activity. Sabialimon P significantly reduces the secretion of TNF-α, iNOS, IL-6 and NF-κB and inhibits the expression of COX-2 and NF-κB/p65 in RAW264.7 cells induced by LPS (HY-D1056)[1].

Molecular Weight

486.73

Formula

C31H50O4
CAS No.
SMILES

COC([C@]12[C@](CC(C)(CC2)C)([H])C3=CC[C@@]([C@@]4([C@@](C(C)([C@H](C[C@@H]4O)O)C)([H])CC5)C)([H])[C@]5(C)[C@@]3(CC1)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sabialimon P Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sabialimon P2267333-96-8NO SynthaseTNF ReceptorNF-κBCOXInterleukin RelatedNitric oxide synthasesNOSTumor Necrosis Factor ReceptorTNFRNuclear factor-κBNuclear factor-kappaBCyclooxygenaseILNO synthaseinhibitoranti-inflammatoryRAW264.7Inhibitorinhibit

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