2. Others Metabolic Enzyme/Protease
  3. Neprilysin Isotope-Labeled Compounds
  4. Sacubitril-13C4

Sacubitril-13C4 (AHU-377-13C4) is a 13C-labeled version of Sacubitril (HY-15407). Sacubitril is an orally active inhibitor of neprilysin NEP (IC50=5 nM). Sacubitril is used in research on heart failure, hypertension and COVID-19.

For research use only. We do not sell to patients.

Sacubitril-<sup>13</sup>C<sub>4</sub> Chemical Structure

Sacubitril-13C4 Chemical Structure

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Description

Sacubitril-13C4 (AHU-377-13C4) is a 13C-labeled version of Sacubitril (HY-15407). Sacubitril is an orally active inhibitor of neprilysin NEP (IC50=5 nM). Sacubitril is used in research on heart failure, hypertension and COVID-19[1][2][3][4][5].

Molecular Weight

415.46

Formula

C2013C4H29NO5
Unlabeled CAS

149709-62-6
SMILES

O=[13C](N[C@@]([H])(C[C@]([H])(C(OCC)=O)C)CC1=CC=C(C=C1)C2=CC=CC=C2)[13CH2][13CH2][13C](O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Sacubitril-13C4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sacubitril-13C4AHU-377-13C4NeprilysinIsotope-Labeled CompoundsNeutral endopeptidaseNEPCluster of differentiation 10CD10COVID-19neutral endopeptidasenatriuretic peptideantihypertensiveheart failureInhibitorinhibitorinhibit

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