2. Metabolic Enzyme/Protease Others
  3. Neprilysin Isotope-Labeled Compounds
  4. Sacubitril-d4 hemicalcium salt

Sacubitril-d4 hemicalcium salt  (Synonyms: AHU-377-d4 hemicalcium salt)

Cat. No.: HY-15407AS1 Purity: 98.78%
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Sacubitril-d4 hemicalcium salt is the deuterium labeled Sacubitril hemicalcium salt (HY-15407A). Sacubitril hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM.

For research use only. We do not sell to patients.

Sacubitril-d<sub>4</sub> hemicalcium salt Chemical Structure

Sacubitril-d4 hemicalcium salt Chemical Structure

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1 mg USD 150 In-stock
5 mg USD 465 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Sacubitril-d4 hemicalcium salt:

Sacubitril-d4 hemicalcium salt Related Antibodies

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Description

Sacubitril-d4 hemicalcium salt is the deuterium labeled Sacubitril hemicalcium salt (HY-15407A). Sacubitril hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM[1][2][3][4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sacubitril-d4 hemicalcium salt Related Antibodies
Molecular Weight

435.56

Formula

C24H25D4NO50.5Ca
Unlabeled CAS

1369773-39-6
Appearance

Solid

Color

White to off-white

SMILES

C[C@H](C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(C([2H])(C([2H])(C([O-])=O)[2H])[2H])=O)C(OCC)=O.[0.5Ca2+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMF : ≥ 20 mg/mL (45.92 mM)

DMSO : ≥ 20 mg/mL (45.92 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 20 mg/mL (45.92 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 20 mg/mL (45.92 mM)

Ethanol : ≥ 5 mg/mL (11.48 mM)

Ethanol : ≥ 5 mg/mL (11.48 mM)

DMSO:PBS(pH 7.2) (1:3) : ≥ 0.25 mg/mL (0.57 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2959 mL 11.4795 mL 22.9590 mL
5 mM 0.4592 mL 2.2959 mL 4.5918 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / Ethanol / DMF / DMSO / DMSO / DMF 1 mM 2.2959 mL 11.4795 mL 22.9589 mL 57.3974 mL
5 mM 0.4592 mL 2.2959 mL 4.5918 mL 11.4795 mL
10 mM 0.2296 mL 1.1479 mL 2.2959 mL 5.7397 mL
DMF / DMSO / DMSO / DMF 15 mM 0.1531 mL 0.7653 mL 1.5306 mL 3.8265 mL
20 mM 0.1148 mL 0.5740 mL 1.1479 mL 2.8699 mL
25 mM 0.0918 mL 0.4592 mL 0.9184 mL 2.2959 mL
30 mM 0.0765 mL 0.3826 mL 0.7653 mL 1.9132 mL
40 mM 0.0574 mL 0.2870 mL 0.5740 mL 1.4349 mL
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Sacubitril-d4 hemicalcium salt Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sacubitril-d4 hemicalciumAHU-377-d4 hemicalciumNeprilysinIsotope-Labeled CompoundsNeutral endopeptidaseNEPCluster of differentiation 10CD10IsotopeLabeledNEP inhibitorheart failureInhibitorinhibitorinhibit

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