2. Others Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds Neprilysin
  4. Sacubitrilat-d4

Sacubitrilat-d4  (Synonyms: Desethyl Sacubitril-d4; LBQ-657-d4)

Cat. No.: HY-17620S Purity: 99.28%
SDS
COA
Handling Instructions Technical Support

Sacubitrilat-d4 is the deuterium labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor[1].

For research use only. We do not sell to patients.

Sacubitrilat-d<sub>4</sub> Chemical Structure

Sacubitrilat-d4 Chemical Structure

Size Price Stock Quantity
1 mg Get quote 2-4 weeks 2-4 weeks 2-4 weeks
5 mg Get quote 2-4 weeks 2-4 weeks 2-4 weeks
10 mg Get quote 2-4 weeks 2-4 weeks 2-4 weeks
50 mg   Get quote  
100 mg   Get quote  
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Other Forms of Sacubitrilat-d4:

Sacubitrilat-d4 Related Antibodies

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Description

Sacubitrilat-d4 is the deuterium labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sacubitrilat-d4 Related Antibodies
Molecular Weight

387.46

Formula

C22H21D4NO5
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

OC([C@H](C)C[C@H](NC(C([2H])([2H])C([2H])([2H])C(O)=O)=O)CC(C=C1)=CC=C1C2=CC=CC=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (258.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5809 mL 12.9046 mL 25.8091 mL
5 mM 0.5162 mL 2.5809 mL 5.1618 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5809 mL 12.9046 mL 25.8091 mL 64.5228 mL
5 mM 0.5162 mL 2.5809 mL 5.1618 mL 12.9046 mL
10 mM 0.2581 mL 1.2905 mL 2.5809 mL 6.4523 mL
15 mM 0.1721 mL 0.8603 mL 1.7206 mL 4.3015 mL
20 mM 0.1290 mL 0.6452 mL 1.2905 mL 3.2261 mL
25 mM 0.1032 mL 0.5162 mL 1.0324 mL 2.5809 mL
30 mM 0.0860 mL 0.4302 mL 0.8603 mL 2.1508 mL
40 mM 0.0645 mL 0.3226 mL 0.6452 mL 1.6131 mL
50 mM 0.0516 mL 0.2581 mL 0.5162 mL 1.2905 mL
60 mM 0.0430 mL 0.2151 mL 0.4302 mL 1.0754 mL
80 mM 0.0323 mL 0.1613 mL 0.3226 mL 0.8065 mL
100 mM 0.0258 mL 0.1290 mL 0.2581 mL 0.6452 mL
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Sacubitrilat-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sacubitrilat-d4Desethyl Sacubitril-d4LBQ-657-d4Isotope-Labeled CompoundsNeprilysinNeutral endopeptidaseNEPCluster of differentiation 10CD10Inhibitorinhibitorinhibit

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