Salviolone 

Salviolone is a natural diterpenoid derivative that can against melanoma cells. Salviolone exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells^[1].

Salviolone (5-60 μM; 72 hours) reduces cell viability in the A375 and MeWo melanoma cell lines with EC₅₀ values of 17 µM and 22 µM, respectively. Salviolone does not affect the growth of normal melanocytes^[1].
Salviolone (20 μM; 48-72 hours) strongly reduces pRb, pCdk2, and cyclin A2, Tyr705-STAT3 phosphorylation expression levels in A375 cells. Salviolone also strongly increases the P21 and P53 protein expression level. Salviolone induces sustained activation of the phosphorylation of ERK1/2 and Akt^[1].
Salviolone (10-20 μM) inhibits MMP2 gelatinase activity in the A375 melanoma cell line^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

268.35

C₁₈H₂₀O₂

119400-86-1

Solid

Light yellow to yellow

O=C1C(C)=CC2=CC=C3C(C)(C)CCCC3=C2C=C1O

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Valentina Zanrè, et al. Salviolone from Salvia miltiorrhiza Roots Impairs Cell Cycle Progression, Colony Formation, and Metalloproteinase-2 Activity in A375 Melanoma Cells: Involvement of P21(Cip1/Waf1) Expression and STAT3 Phosphorylation. Int J Mol Sci. 2022 Jan 20;23(3):1121.  [Content Brief]