Saprorthoquinone (Synonyms: NSC 648341)

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Saprorthoquinone (NSC 648341) is a diterpenoid that can be found in salvia atropatana. Saprorthoquinone shows cytotoxicity for PC3 cells.

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Saprorthoquinone Chemical Structure

CAS No. : 102607-41-0

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Description

Saprorthoquinone (NSC 648341) is a diterpenoid that can be found in salvia atropatana. Saprorthoquinone shows cytotoxicity for PC3 cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	2.36 μM Compound: 1	In vitro cytotoxic activity against HL-60 human leukemia cell line was determined by MTT assay (microculture terazolium colorimetric) In vitro cytotoxic activity against HL-60 human leukemia cell line was determined by MTT assay (microculture terazolium colorimetric)	[PMID: 10509925]
P388	IC₅₀	1.95 μM Compound: 1	In vitro cytotoxic activity against P388 mouse leukemia cell line by MTT assay (microculture terazolium colorimetric) In vitro cytotoxic activity against P388 mouse leukemia cell line by MTT assay (microculture terazolium colorimetric)	[PMID: 10509925]
SGC-7901	IC₅₀	1.37 μM Compound: 1	In vitro cytotoxic activity against SGC-7901 stomach cancer solid tumor cell line by MTT assay (microculture terazolium colorimetric) In vitro cytotoxic activity against SGC-7901 stomach cancer solid tumor cell line by MTT assay (microculture terazolium colorimetric)	[PMID: 10509925]
SPC-A4	IC₅₀	2.75 μM Compound: 1	In vitro cytotoxic activity against SPC-A4 lung cancer solid tumor cell line by MTT assay (microculture terazolium colorimetric) In vitro cytotoxic activity against SPC-A4 lung cancer solid tumor cell line by MTT assay (microculture terazolium colorimetric)	[PMID: 10509925]

Molecular Weight

296.40

Formula

C₂₀H₂₄O₂

CAS No.

102607-41-0

SMILES

C/C(C)=C\CCC(C(C)=CC=C1C=C(C(C)C)C2=O)=C1C2=O

Structure Classification

Initial Source

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shakeri A, et al. 4,5-Seco-5,10-friedo-abietane-type diterpenoids with anticancer activity from Salvia atropatana Bunge. Naunyn Schmiedebergs Arch Pharmacol. 2021 Feb;394(2):241-248. [Content Brief]

Saprorthoquinone Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Saprorthoquinone102607-41-0NSC 648341NSC648341NSC-648341OthersInhibitorinhibitorinhibit

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