Sarizotan dihydrochloride (Synonyms: EMD 128130 dihydrochloride)

Cat. No.: HY-100820B: FAQs
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Sarizotan dihydrochloride (EMD 128130) is an orally active serotonin 5-HT_1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC₅₀ values of 6.5 nM (rat 5-HT_1A), 0.1 nM (human 5-HT_1A), 15.1 nM (rat D₂), 17 nM (human D₂), 6.8 nM (human D₃) and 2.4 nM (human D_4.2), respectively.

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Sarizotan dihydrochloride Chemical Structure

CAS No. : 177976-12-4

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Other In-stock Forms of Sarizotan dihydrochloride:

Sarizotan

Other Forms of Sarizotan dihydrochloride:

Sarizotan In-stock

1 Publications Citing Use of MCE Sarizotan dihydrochloride

•Cell Death Dis. 2024 Jun 12;15(6):411. [Abstract]

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•Related Small Molecules:

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5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

5-HT_1A Receptor

0.1 nM (IC₅₀)

Human D₃ Receptor

6.8 nM (IC₅₀)

5-HT_2A Receptor

587 nM (IC₅₀)

5-HT_2B Receptor

108 nM (IC₅₀)

5-HT_5A Receptor

313 nM (IC₅₀)

Human 5-HT₆ Receptor

3300 nM (IC₅₀)

Human 5-HT₇ Receptor

10 nM (IC₅₀)

Molecular Weight

421.34

Formula

C₂₂H₂₃Cl₂FN₂O

CAS No.

177976-12-4

SMILES

FC(C=C1)=CC=C1C2=CN=CC(CNC[C@@H]3OC4=CC=CC=C4CC3)=C2.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. G D Bartoszyk, et al. Sarizotan, a Serotonin 5-HT1A Receptor Agonist and Dopamine Receptor Ligand. J Neural Transm (Vienna). 2004 Feb;111(2):113-26. [Content Brief]

[2]. C Marin, et al. Local Administration of Sarizotan Into the Subthalamic Nucleus Attenuates Levodopa-Induced Dyskinesias in 6-OHDA-lesioned Rats. Psychopharmacology (Berl). 2009 Jun;204(2):241-50. [Content Brief]

Sarizotan dihydrochloride Related Classifications

Neurological Disease

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sarizotan177976-12-4EMD 128130EMD128130EMD-1281305-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorParkinson’sdiseaseDOPAdyskinesiaInhibitorinhibitorinhibit

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