2. Metabolic Enzyme/Protease Anti-infection
  3. Cathepsin SARS-CoV
  4. SARS-CoV-2-IN-77

SARS-CoV-2-IN-77 (compound 11e) is a cathepsin L and cathepsin S inhibitor with Ki values of 111 nM and 103 nM, respectively. SARS-CoV-2-IN-77 inhibits SARS-CoV-2 with an EC50 value of 38.4 nM in Calu-3 cells without showing cytotoxicity.

For research use only. We do not sell to patients.

SARS-CoV-2-IN-77 Chemical Structure

SARS-CoV-2-IN-77 Chemical Structure

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SARS-CoV-2-IN-77 Related Antibodies

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Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

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Description

SARS-CoV-2-IN-77 (compound 11e) is a cathepsin L and cathepsin S inhibitor with Ki values of 111 nM and 103 nM, respectively. SARS-CoV-2-IN-77 inhibits SARS-CoV-2 with an EC50 value of 38.4 nM in Calu-3 cells without showing cytotoxicity[1].

IC50 & Target[1]

cathepsin L

111 nM (Ki)

cathepsin S

103 nM (Ki)

SARS-CoV-2

38.4 nM (EC50)

Molecular Weight

462.37

Formula

C23H25Cl2N3O3
SMILES

CC(C[C@@H](C(N[C@@H](CC1=CC=CC=C1)C#N)=O)NC(COC2=C(C=C(C=C2)Cl)Cl)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SARS-CoV-2-IN-77 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2-IN-77CathepsinSARS-CoVSARS coronaviruscathepsin Lcathepsin SSARS-CoV-2Inhibitorinhibitorinhibit

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