Sarubicin B

Cat. No.: HY-123436: FAQs
Data Sheet Handling Instructions Technical Support

Sarubicin B is an active product that can be isolated from the culture filtrate of a Streptomyces strain JA 2861. Sarubicin B is a quinone antibiotic that inhibit Gram-positive bacteria and not active against Gram-negative microorganisms.

For research use only. We do not sell to patients.

Sarubicin B Chemical Structure

CAS No. : 84745-01-7

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	7.6 μM Compound: 2	Cytotoxicity against mouse 4T1 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay Cytotoxicity against mouse 4T1 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay	[PMID: 35213166]
A549	IC₅₀	13.5 μM Compound: 2	Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay	[PMID: 35213166]
HCT-116	IC₅₀	14.8 μM Compound: 2	Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay	[PMID: 35213166]
HepG2	IC₅₀	6.3 μM Compound: 2	Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by CCK8 assay	[PMID: 35213166]

Molecular Weight

258.23

Formula

C₁₃H₁₀N₂O₄

CAS No.

84745-01-7

SMILES

O=C(N)C(C1=O)=C(C(C2=C1C=CC=C2C(C)=O)=O)N

Structure Classification

Initial Source

Microorganisms

streptomyces strain

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. K Eckardt, et al. Sarubicin b, a new quinone antibiotic, isolated from the fermentation broth of a streptomyces strain. J Antibiot (Tokyo). 1982 Dec;35(12):1638-40. [Content Brief]

Sarubicin B Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sarubicin B84745-01-7AntibioticBacterialInhibitorinhibitorinhibit

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