2. Immunology/Inflammation
  3. Interleukin Related
  4. Satralizumab

Satralizumab, a humanized monoclonal antibody, is a potent Interleukine-6 (IL-6) inhibitor. Satralizumab prevents dTAA formation and progression in rattus norvegicus. Satralizumab can be used for neuromyelitis optica spectrum disorder (NMOSD) and descending thoracic aorta aneurysm (dTAA) research.

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CAS No. : 1535963-91-7

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Satralizumab Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

Satralizumab, a humanized monoclonal antibody, is a potent Interleukine-6 (IL-6) inhibitor. Satralizumab prevents dTAA formation and progression in rattus norvegicus. Satralizumab can be used for neuromyelitis optica spectrum disorder (NMOSD) and descending thoracic aorta aneurysm (dTAA) research[1][2].

Isotype

Human IgG2 kappa
Recommend Isotype Controls
Species

Humanized
IC50 & Target

IL-6

 

In Vivo

Satralizumab (120 mg, Subcutaneously, once every 2 weeks, for 4 weeks) prevents dTAA formation and progression in rattus norvegicus[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rattus norvegicus (forty, male, 10-week-old, four equal groups)[1]
Dosage: 120 mg
Administration: Subcutaneously, once every 2 weeks, for 4 weeks
Result: Prevented dTAA (descending thoracic aorta aneurysm) formation and progression.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Satralizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 kappa
Purity & Documentation
References
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Satralizumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Satralizumab1535963-91-7Interleukin RelatedILlongitudinally extensive transverse myelitismonoclonal antibodyneuromyelitis optica spectrum disorderNMONMOSDdescending thoracic aorta aneurysmInhibitorinhibitorinhibit

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