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  4. SB-258585 hydrochloride

SB-258585 is a high affinity ligand for the 5-HT6 receptor. SB-258585 binds highly to a single receptor population in a human cell line that recombines 5-HT6 receptors. SB-258585 can be used to label recombinant and natural 5-HT6 receptor .

For research use only. We do not sell to patients.

SB-258585 hydrochloride Chemical Structure

SB-258585 hydrochloride Chemical Structure

CAS No. : 1216468-02-8

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1 mg USD 40 In-stock
5 mg USD 120 In-stock
10 mg USD 195 In-stock
25 mg USD 420 In-stock
50 mg USD 690 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

SB-258585 is a high affinity ligand for the 5-HT6 receptor. SB-258585 binds highly to a single receptor population in a human cell line that recombines 5-HT6 receptors. SB-258585 can be used to label recombinant and natural 5-HT6 receptor [1].

Molecular Weight

523.82

Formula

C18H23ClIN3O3S
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

O=S(C1=CC=C(I)C=C1)(NC2=CC=C(OC)C(N3CCN(C)CC3)=C2)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (238.63 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9091 mL 9.5453 mL 19.0905 mL
5 mM 0.3818 mL 1.9091 mL 3.8181 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9091 mL 9.5453 mL 19.0905 mL 47.7263 mL
5 mM 0.3818 mL 1.9091 mL 3.8181 mL 9.5453 mL
10 mM 0.1909 mL 0.9545 mL 1.9091 mL 4.7726 mL
15 mM 0.1273 mL 0.6364 mL 1.2727 mL 3.1818 mL
20 mM 0.0955 mL 0.4773 mL 0.9545 mL 2.3863 mL
25 mM 0.0764 mL 0.3818 mL 0.7636 mL 1.9091 mL
30 mM 0.0636 mL 0.3182 mL 0.6364 mL 1.5909 mL
40 mM 0.0477 mL 0.2386 mL 0.4773 mL 1.1932 mL
50 mM 0.0382 mL 0.1909 mL 0.3818 mL 0.9545 mL
60 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.7954 mL
80 mM 0.0239 mL 0.1193 mL 0.2386 mL 0.5966 mL
100 mM 0.0191 mL 0.0955 mL 0.1909 mL 0.4773 mL
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SB-258585 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-2585851216468-02-8SB258585SB 258585Others5-HT6 receptorsradioligand bindingHeLa cellsInhibitorinhibitorinhibit

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