2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. SCH 336

SCH 336  (Synonyms: SCH-225336)

Cat. No.: HY-121852 Purity: 98.85%
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SCH 336 is a potent, selective, inverse and orally active CB2 agonist. SCH 336 inhibits BaF3/CB2 migration. SCH 336 significantly inhibits the migration of leukocytes in vivo. SCH 336 blocks ovalbumin-induced lung eosinophilia in mice.

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SCH 336 Chemical Structure

SCH 336 Chemical Structure

CAS No. : 447459-51-0

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Based on 1 publication(s) in Google Scholar

SCH 336 Related Antibodies

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Description

SCH 336 is a potent, selective, inverse and orally active CB2 agonist. SCH 336 inhibits BaF3/CB2 migration. SCH 336 significantly inhibits the migration of leukocytes in vivo. SCH 336 blocks ovalbumin-induced lung eosinophilia in mice[1].

IC50 & Target[1]

hCB2-R

 

In Vitro

SCH 336 (Sch.336) (0-10 µM) competes with [3H]CP55,940 for binding to human CB2 on Sf9 cell membranes with Ki of 1.8 nM, and decreases GTPγS binding on human CB2-containing membranes with an EC50 of 2 nM, decreases potency on CB1-containing membranes with EC50 of 200 nM[1].
SCH 336 inhibits BaF3/CB2 migration to 100 nM 2-AG with an IC50 of 34 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SCH 336 Related Antibodies
In Vivo

SCH 336 (0.02, 0.2, 2.0 mg/kg; i.p.) significantly inhibits the migration of leukocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female B6D2/F1 mice (HU210)[1]
Dosage: 0.02, 0.2, 2.0 mg/kg
Administration: I.p.
Result: Significantly inhibited the migration of leukocytes into the CCL2-soaked gel foam sponge.
Molecular Weight

539.64

Formula

C23H25NO8S3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CS(N[C@H](C1=CC=C(C=C1)S(C2=C(C=C(C=C2)OC)S(=O)(C3=CC=C(C=C3)OC)=O)(=O)=O)C)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (185.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8531 mL 9.2654 mL 18.5309 mL
5 mM 0.3706 mL 1.8531 mL 3.7062 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8531 mL 9.2654 mL 18.5309 mL 46.3272 mL
5 mM 0.3706 mL 1.8531 mL 3.7062 mL 9.2654 mL
10 mM 0.1853 mL 0.9265 mL 1.8531 mL 4.6327 mL
15 mM 0.1235 mL 0.6177 mL 1.2354 mL 3.0885 mL
20 mM 0.0927 mL 0.4633 mL 0.9265 mL 2.3164 mL
25 mM 0.0741 mL 0.3706 mL 0.7412 mL 1.8531 mL
30 mM 0.0618 mL 0.3088 mL 0.6177 mL 1.5442 mL
40 mM 0.0463 mL 0.2316 mL 0.4633 mL 1.1582 mL
50 mM 0.0371 mL 0.1853 mL 0.3706 mL 0.9265 mL
60 mM 0.0309 mL 0.1544 mL 0.3088 mL 0.7721 mL
80 mM 0.0232 mL 0.1158 mL 0.2316 mL 0.5791 mL
100 mM 0.0185 mL 0.0927 mL 0.1853 mL 0.4633 mL
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SCH 336 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCH 336447459-51-0SCH-225336SCH336SCH-336SCH225336SCH 225336Cannabinoid Receptorselectiveinverseorally activeBaF3 cellsleukocytesmigration immunomodulatory agentInhibitorinhibitorinhibit

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