SD-1029

Cat. No.: HY-112391: FAQs
Data Sheet Handling Instructions

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SD-1029 is a JAK2/STAT3 inhibitor. SD-1029 inhibits STAT3 nuclear translocation. SD-1029 is an inhibitor of STAT3 activation due to inhibition of JAK2 phosphorylation.

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SD-1029 Chemical Structure

CAS No. : 118372-34-2

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1 Publications Citing Use of MCE SD-1029

•Exp Ther Med. 2023 Jun 7.

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JAK1 JAK2 JAK3 Tyk2 JAK

View All STAT Isoform Specific Products:

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STAT3 STAT5 STAT6 STAT1

Biological Activity
Purity & Documentation
References
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Description

SD-1029 is a JAK2/STAT3 inhibitor^[1]. SD-1029 inhibits STAT3 nuclear translocation. SD-1029 is an inhibitor of STAT3 activation due to inhibition of JAK2 phosphorylation^[2].

IC₅₀ & Target^[1]

STAT3

JAK2

In Vitro

SD-1029 (10 μM) inhibits EGFP-Stat3 nuclear translocation in BHK-21 and U-2OS cells^[1].
SD-1029 (5 and 10 μM; 24 hours) inhibits cell growth and induces apoptosis in OVCAR8_TR ovarian cancer cells^[1].
SD-1029 (10 μM; 24 hours) suppresses p-Stat3 levels in human breast and ovarian cancer cell lines^[1].
SD-1029 inhibits not only JAK2 phosphorylation, but also the phosphorylation of STAT1 and STAT3. SD-1029 strongly inhibits Tyk2 phosphorylation, implicating both JAK2 and Tyk2 as upstream requirements for IL-23-induced IL-23R expression^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	OVCAR8_TR ovarian cancer cells
Concentration:	5 and 10 μM
Incubation Time:	24 hours
Result:	Down-regulated cell proliferation, and induced apoptotic cell death. Treatment resulted in a marked, 20-fold induction of apoptosis in the OVCAR8_TR cells that express constitutively activated Stat3.

Western Blot Analysis^[1]

Cell Line:	MDA-MB-468 and MDA435 (breast cancer), OV1063 (ovarian cancer), and the paclitaxel-resistant ovarian cancer daughter lines, SKOV-3_TR and OVCAR8_TR.
Concentration:	10 μM
Incubation Time:	24 hours
Result:	Led to reduced levels of pStat3.

Molecular Weight

639.25

Formula

C₂₅H₃₂Br₂Cl₂N₂O₃

CAS No.

118372-34-2

SMILES

O=C1C(C(C2=CC=C(Cl)C(Cl)=C2)C3=C(CCC(CN(C)C)C3=O)O4)=C4CCC1CN(C)C.[H]Br.[H]Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhenfeng Duan, et al. SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation. Clin Cancer Res. 2006 Nov 15;12(22):6844-52. [Content Brief]

[2]. Nor Fazila Che Mat, et al. Interleukin-23-induced interleukin-23 receptor subunit expression is mediated by the Janus kinase/signal transducer and activation of transcription pathway in human CD4 T cells. J Interferon Cytokine Res. 2011 Apr;31(4):363-71. [Content Brief]

SD-1029 Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SD-1029118372-34-2SD1029SD 1029JAKSTATJanus kinaseSTAT3nucleartranslocationJAK2phosphorylationInhibitorinhibitorinhibit

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