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NOG

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Compare Product Name Species Source
  • HY-P700802
    Nogo Receptor/NgR Protein, Cynomolgus (HEK293, His)

    NOGo receptor; RTN4R; NOGOR; NgR1; NOGo-66 receptor; NGR

    		 Cynomolgus HEK293
    Nogo Receptor/NgR Protein functions as a versatile receptor for RTN4, OMG, and MAG, broadening its recognition to include sialylated gangliosides GT1b and GM1, chondroitin sulfate proteoglycans, and heparin. NGFR coreceptor activation initiates Rho-mediated actin cytoskeleton reorganization, leading to axonal growth inhibition. NgR plays a crucial role in axon regeneration and neuronal plasticity in the adult central nervous system, contributing to postnatal brain development, axon migration, and corpus callosum formation. It also protects motoneurons against apoptosis, potentially mediated by its interaction with MAG. Collaborating with RTN4 and LINGO1, NgR regulates neuronal precursor cell motility during cortical development. As a homodimer, it engages in a complex molecular network with OMG, MAG, RTN4, NGFR, LINGO1, KIAA0319L, and OLFM1, revealing its multifaceted roles in cellular processes and neural development. Nogo Receptor/NgR Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Nogo Receptor/NgR protein, expressed by HEK293, with C-His labeled tag. The total length of Nogo Receptor/NgR Protein, Cynomolgus (HEK293, His) is 421 a.a., with molecular weight of 60-73 kDa.

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