α-(1-2,3,6) Mannosidase

By Targets:	Antibiotic (1) Apoptosis (1) Biochemical Assay Reagents (4) Endogenous Metabolite (2) Fluorescent Dye (1) Glycosidase (2) HIV (1) Influenza Virus (1)
By Research Areas:	Cancer (1) Infection (2) Inflammation/Immunology (1) Metabolic Disease (5)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2950A

*α1-6 Mannosidase, Xanthomonas phaseoli*	Glycosidase	Metabolic Disease
α1-6 Mannosidase, Xanthomonas phaseoli is a highly specific exoglycosidase that removes unbranched α1-6 linked mannose residues from oligosaccharides .

HY-19332

Kifunensine Maximum Cited Publications 8 Publications Verification FR-900494	Glycosidase	Inflammation/Immunology
Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD .

HY-W009122

4-Methylumbelliferyl-α-d-mannoside 4-Methylumbelliferyl-alpha-d-mannoside	Biochemical Assay Reagents	Others
4-Methylumbelliferyl-α-d-mannoside is a fluorescent substrate for α-D-mannosidase.

HY-W009783

1-Deoxymannojirimycin hydrochloride 1 Publications Verification	HIV Influenza Virus	Infection
1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC₅₀ of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor and inhibits HIV‐1 strains. 1-Deoxymannojirimycin hydrochloride has antiviral activity .

HY-N1470

Plantagoside	Others	Metabolic Disease
Plantagoside, isolated from the seeds of Plantago asiatica, is a specific and non-competitive inhibitor for jack bean *α-mannosidase, with an IC₅₀* of 5 μM .

HY-P2950

α-Mannosidase	Biochemical Assay Reagents	Others
α-Mannosidase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P2858

β-Mannosidase	Endogenous Metabolite	Metabolic Disease
β-Mannosidase is a lysosomal enzyme from the glycosyl hydrolase family 2 that cleaves the single β(1-4)-linked mannose at the nonreducing end of N-glycosylated proteins, and plays an important role in the polysaccharide degradation pathway .

HY-P2950B

α-(1-2,3,6) Mannosidase	Biochemical Assay Reagents	Others
α-(1-2,3,6) Mannosidase is a glycosidase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .

HY-E70304

*Mannosyl-oligosaccharide 1,2-α-mannosidase* IA** MAN1A1	Endogenous Metabolite	Others
Mannosyl-oligosaccharide 1,2-α-mannosidase IA (MAN1A1) is a glycosidase that catalyzes the hydrolysis of α-1,2-linked mannose residues in Man(9)GlcNAc(2) to produce Man(9)GlcNAc(2) .

HY-137496

4-Methylumbelliferyl β-D-mannopyranoside	Biochemical Assay Reagents
4-Methylumbelliferyl β-D-mannopyranoside is a substrate that exhibits β-mannosidase activity. 4-Methylumbelliferyl β-D-mannopyranoside can be used to study β-mannosidase deficiency. The reactivity of 4-Methylumbelliferyl β-D-mannopyranoside shows different inhibitory effects on various substrates.

HY-W357151

6-Chloro-3-indoxyl-α-D-mannopyranoside	Fluorescent Dye	Others
6-Chloro-3-indoxyl-α-D-mannopyranoside is a chromogenic substrate for α-mannosidase resulting in a salmon colored precipitate upon cleavage.

HY-N1470R

Plantagoside (Standard)	Others	Metabolic Disease
Plantagoside (Standard) is the analytical standard of Plantagoside. This product is intended for research and analytical applications. Plantagoside, isolated from the seeds of Plantago asiatica, is a specific and non-competitive inhibitor for jack bean α-mannosidase, with an IC50 of 5 μM .

HY-N6722

Swainsonine 1 Publications Verification Tridolgosir	Apoptosis Antibiotic	Infection Cancer
Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible *α-mannosidase* inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity .

Cat. No.	Product Name	Type

HY-W357151

6-Chloro-3-indoxyl-α-D-mannopyranoside	Chromogenic Substrates
6-Chloro-3-indoxyl-α-D-mannopyranoside is a chromogenic substrate for α-mannosidase resulting in a salmon colored precipitate upon cleavage.

Cat. No.	Product Name	Type

HY-W009122

4-Methylumbelliferyl-α-d-mannoside 4-Methylumbelliferyl-alpha-d-mannoside	Carbohydrates
4-Methylumbelliferyl-α-d-mannoside is a fluorescent substrate for α-D-mannosidase.

HY-E70185

Lysosomal α-mannosidase EC:3.2.1.24; MAN2B1; LAMAN	Enzyme Substrates
Lysosomal α-mannosidase (EC:3.2.1.24; MAN2B1; LAMAN) is an exoglycosidase that hydrolyzes α-mannosidic linkages of mannoglycans. Lysosomal α-mannosidase can be used in the study of α-mannosidosis .

HY-137496

4-Methylumbelliferyl β-D-mannopyranoside	Enzyme Substrates
4-Methylumbelliferyl β-D-mannopyranoside is a substrate that exhibits β-mannosidase activity. 4-Methylumbelliferyl β-D-mannopyranoside can be used to study β-mannosidase deficiency. The reactivity of 4-Methylumbelliferyl β-D-mannopyranoside shows different inhibitory effects on various substrates.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-19332

Kifunensine Maximum Cited Publications 8 Publications Verification FR-900494	Alkaloids Piperidine Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Glycosidase
Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD .

HY-W009783

1-Deoxymannojirimycin hydrochloride 1 Publications Verification	Infection Alkaloids Piperidine Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields	HIV Influenza Virus
1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC₅₀ of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor and inhibits HIV‐1 strains. 1-Deoxymannojirimycin hydrochloride has antiviral activity .

HY-N1470

Plantagoside	Plantaginaceae Structural Classification Flavonoids Classification of Application Fields Flavonones Source classification Phenols Polyphenols Metabolic Disease Plantago asiatica L. Plants Disease Research Fields	Others
Plantagoside, isolated from the seeds of Plantago asiatica, is a specific and non-competitive inhibitor for jack bean *α-mannosidase, with an IC₅₀* of 5 μM .

HY-N6722

Swainsonine 1 Publications Verification Tridolgosir	Infection Alkaloids Piperidine Alkaloids Structural Classification Pyrrole Alkaloids Classification of Application Fields Leguminosae Source classification Plants Disease Research Fields Sphaerophysa salsula	Apoptosis Antibiotic
Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible *α-mannosidase* inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity .

HY-N1470R

Plantagoside (Standard)	Plantaginaceae Structural Classification Flavonoids Flavonones Source classification Phenols Polyphenols Plantago asiatica L. Plants	Others
Plantagoside (Standard) is the analytical standard of Plantagoside. This product is intended for research and analytical applications. Plantagoside, isolated from the seeds of Plantago asiatica, is a specific and non-competitive inhibitor for jack bean α-mannosidase, with an IC50 of 5 μM .

Species:	Human (3)
Tag:	His (3) Tag Free (1)
Source:	HEK293 (3) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70957

	MAN1B1 Protein, Human (HEK293, His) Endoplasmic Reticulum Mannosyl-Oligosaccharide 1; 2-Alpha-Mannosidase; ER Alpha-1; 2-Mannosidase; ER Mannosidase 1; ERMan1; Man9GlcNAc2-Specific-Processing Alpha-Mannosidase; Mannosidase Alpha Class 1B Member 1; MAN1B1	Human	HEK293
	MAN1B1, integral to glycoprotein quality control, trims a single alpha-1,2-linked mannose from Man(9)GlcNAc(2), producing Man(8)GlcNAc(2). In the ERQC, elevated enzyme concentrations allow further trimming to Man(5-6)GlcNAc(2). This enzymatic function is crucial for glycoprotein processing and quality control in the endoplasmic reticulum, ensuring proper folding and maturation. MAN1B1 Protein, Human (HEK293, His) is the recombinant human-derived MAN1B1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MAN1B1 Protein, Human (HEK293, His) is 594 a.a., with molecular weight of 58-80 kDa.

HY-P76485

	MAN1A2 Protein, Human (HEK293, His) Mannosyl-oligosaccharide 1,2-alpha-Mannosidase IB; Alpha-1,2-Mannosidase IB; MAN1B	Human	HEK293
	The MAN1A2 protein is crucially involved in the maturation of Asn-linked oligosaccharides, which in turn trims α-1,2-linked mannose residues from Man(9)GlcNAc(2) to generate Man(5)GlcNAc(2). During glycosylation, MAN1A2 plays a key role in the progressive trimming of mannose residues that are essential for generating mature glycan structures. MAN1A2 Protein, Human (HEK293, His) is the recombinant human-derived MAN1A2 protein, expressed by HEK293 , with N-His labeled tag. The total length of MAN1A2 Protein, Human (HEK293, His) is 584 a.a., with molecular weight of ~69 KDa.

HY-P76897

	EDEM2 Protein, Human (HEK293, His) ER degradation-enhancing alpha-Mannosidase-like protein 2; C20orf31; C20orf49	Human	HEK293
	EDEM2 Protein is involved in the endoplasmic reticulum-associated degradation (ERAD) pathway. EDEM2 Protein, Human (HEK293, His) is the recombinant human-derived EDEM2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P702174

	Beta-mannanase Protein, Lonsdalea quercina SAMN02982996_03194; Mannan endo-1; 4-beta-Mannosidase	Others	E. coli
	Beta-mannanase is a member of the glycosyl hydrolase 26 family. Beta-mannanase Protein, Lonsdalea quercina is the recombinant Beta-mannanase protein, expressed by E. coli , with tag free.

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α-(1-2,3,6) Mannosidase

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