1-Deoxymannojirimycin hydrochloride

Name: 1-Deoxymannojirimycin hydrochloride
Brand: MedChemExpress
SKU: HY-W009783
Rating: 4.5 (1 reviews)

Cat. No.: HY-W009783 Purity: 99.06%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC₅₀ of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor and inhibits HIV‐1 strains. 1-Deoxymannojirimycin hydrochloride has antiviral activity.

For research use only. We do not sell to patients.

1-Deoxymannojirimycin hydrochloride Chemical Structure

CAS No. : 73465-43-7

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 88	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 88	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 32	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 125	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 385	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 610	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 1-Deoxymannojirimycin hydrochloride:

Deoxymannojirimycin hydrochloride Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 20 μM (α1,2-mannosidase I)^[1]
N-linked glycosylation^[2]
HIV‐1^[2]

Molecular Weight

199.63

Formula

C₆H₁₄ClNO₄

CAS No.

73465-43-7

Appearance

Solid

Color

Off-white to gray

SMILES

O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)NC1.Cl

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (500.93 mM; Need ultrasonic)

DMSO : 50 mg/mL (250.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.0093 mL	25.0463 mL	50.0927 mL
5 mM	1.0019 mL	5.0093 mL	10.0185 mL
10 mM	0.5009 mL	2.5046 mL	5.0093 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 3.5 mg/mL (17.53 mM); Clear solution

This protocol yields a clear solution of ≥ 3.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (35.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 3.5 mg/mL (17.53 mM); Clear solution

This protocol yields a clear solution of ≥ 3.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (35.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 3.5 mg/mL (17.53 mM); Clear solution

This protocol yields a clear solution of ≥ 3.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (35.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (500.93 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.06%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (251 KB) HNMR (244 KB) RP-HPLC (253 KB) MS (115 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)

References

[1]. F Vallee, et al. Structural Basis for Catalysis and Inhibition of N-glycan Processing Class I Alpha 1,2-mannosidases. J Biol Chem. 2000 Dec 29;275(52):41287-98. [Content Brief]

[2]. Jan Balzarini, et al. The alpha(1,2)-mannosidase I Inhibitor 1-deoxymannojirimycin Potentiates the Antiviral Activity of Carbohydrate-Binding Agents Against Wild-Type and Mutant HIV-1 Strains Containing Glycan Deletions in gp120. FEBS Lett. 2007 May 15;581(10):2060-4. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	5.0093 mL	25.0463 mL	50.0927 mL	125.2317 mL
	5 mM	1.0019 mL	5.0093 mL	10.0185 mL	25.0463 mL
	10 mM	0.5009 mL	2.5046 mL	5.0093 mL	12.5232 mL
	15 mM	0.3340 mL	1.6698 mL	3.3395 mL	8.3488 mL
	20 mM	0.2505 mL	1.2523 mL	2.5046 mL	6.2616 mL
	25 mM	0.2004 mL	1.0019 mL	2.0037 mL	5.0093 mL
	30 mM	0.1670 mL	0.8349 mL	1.6698 mL	4.1744 mL
	40 mM	0.1252 mL	0.6262 mL	1.2523 mL	3.1308 mL
	50 mM	0.1002 mL	0.5009 mL	1.0019 mL	2.5046 mL
	60 mM	0.0835 mL	0.4174 mL	0.8349 mL	2.0872 mL
	80 mM	0.0626 mL	0.3131 mL	0.6262 mL	1.5654 mL
	100 mM	0.0501 mL	0.2505 mL	0.5009 mL	1.2523 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.