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Results for "

α-adrenoceptors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (14) Calcium Channel (1) Dopamine Receptor (4) Histamine Receptor (2) Imidazoline Receptor (1) Influenza Virus (1) Isotope-Labeled Compounds (2) Phosphodiesterase (PDE) (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (7) Endocrinology (8) Infection (1) Inflammation/Immunology (2) Neurological Disease (7)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14325

L-745870 2 Publications Verification	Dopamine Receptor	Neurological Disease
L-745870 is a potent, selective, brain-penetrant and orally active dopamine D₄ receptor antagonist with a K_i of 0.43 nM. L-745870 shows weaker affinity for D₂ (K_i of 960 nM) and D₃ (K_i of 2300 nM) receptors, and exhibits moderate affinity for 5-HT₂ receptors, sigma sites and α-adrenoceptors .

HY-14325B

L-745870 hydrochloride 2 Publications Verification	Dopamine Receptor	Neurological Disease
L-745870 hydrochloride is a potent, selective, brain-penetrant and orally active dopamine D₄ receptor antagonist with a K_i of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D₂ (K_i of 960 nM) and D₃ (K_i of 2300 nM) receptors, and exhibits moderate affinity for 5-HT₂ receptors, sigma sites and α-adrenoceptors .

HY-B0431A

Phenoxybenzamine hydrochloride 1 Publications Verification	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Phenoxybenzamine hydrochloride is a nonselective, irreversible, orally active *α-adrenoceptor* antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine hydrochloride also shows antitumor activity .

HY-14325A

L-745870 trihydrochloride	Dopamine Receptor	Neurological Disease
L-745870 trihydrochloride is a potent, selective, brain-penetrant and orally active dopamine D₄ receptor antagonist with a K_i of 0.43 nM. L-745870 trihydrochloride shows weaker affinity for D₂ (K_i of 960 nM) and D₃ (K_i of 2300 nM) receptors, and exhibits moderate affinity for 5-HT₂ receptors, sigma sites and α-adrenoceptors .

HY-119615

Mezilamine	Adrenergic Receptor	Neurological Disease Endocrinology
Mezilamine is a potent antidopaminergic agent. Mezilamine induces a concentration dependent increase in the electrically stimulated overflow of ³H-noradrenaline from rat cortical slices, without affecting the basal overflow. Mezilamine acts as a presynaptic α-adrenoceptor antagonist and a postsynaptic α-adrenoceptor agonist .

HY-N2833

Akuammigine	Adrenergic Receptor	Neurological Disease
Akuammigine is an alkaloid that can be found in hook-bearing branch of Uncariarhynchophylla. Akuammigine is a is a very weak antagonist at pre- and postsynaptic *α-adrenoceptor* of the rat vas deferens .

HY-B0431

Phenoxybenzamine	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Phenoxybenzamine is a nonselective, irreversible, orally active *α-adrenoceptor* antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine also shows antitumor activity .

HY-N4225

Aaptamine	Adrenergic Receptor	Endocrinology Cancer
Aaptamine, a spongean alkaloid isolated from a sea sponge Aaptos aaptos, is a competitive antagonist of *α-adrenoceptor* and activates the p21 promoter in a p53-independent manner .

HY-113985

Cirazoline LD 3098	Imidazoline Receptor Adrenergic Receptor	Neurological Disease
Cirazoline (LD 3098) is a doul agonist of Presynaptic imidazoline receptors (R(i-pre)) and α-adrenoceptor (R(α)). Cirazoline (30 μM) suppresses M current in SCG neurons cultured overnight .

HY-123368

Zolertine hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Zolertine hydrochloride is an *α-adrenoceptor* antagonist with a pK_i of 6.81 in rat liver (α_1B-adrenoceptors) and 6.35 in rabbit liver (α_1A-adrenoceptors) membranes .

HY-B0431AS

Phenoxybenzamine-d5 hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Phenoxybenzamine-d₅ (hydrochloride) is the deuterium labeled Phenoxybenzamine hydrochloride. Phenoxybenzamine hydrochloride is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine hydrochloride also shows antitumor activity[1][2][3].

HY-B0431S

Phenoxybenzamine-d5	Adrenergic Receptor	Cancer
Phenoxybenzamine-d₅ is the deuterium labeled Phenoxybenzamine[1]. Phenoxybenzamine is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine also shows antitumor activity[2][3].

HY-B0431AR

Phenoxybenzamine hydrochloride (Standard)	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Phenoxybenzamine (hydrochloride) (Standard) is the analytical standard of Phenoxybenzamine (hydrochloride). This product is intended for research and analytical applications. Phenoxybenzamine hydrochloride is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine hydrochloride also shows antitumor activity .

HY-B0431AS1

Phenoxybenzamine (benzyl-2,3,4,5,6-d5) (hydrochloride)	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Phenoxybenzamine (benzyl-2,3,4,5,6-d₅) (hydrochloride) is the deuterium labeled Phenoxybenzamine hydrochloride. Phenoxybenzamine hydrochloride is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine hydrochloride also shows antitumor activity[1][2][3].

HY-124517

Burimamide	Histamine Receptor Adrenergic Receptor	Neurological Disease Inflammation/Immunology
Burimamide is a blocker of histamine H2-receptor. Burimamide inhibits gastric acid secretion evoked by Pentagastrin (HY-A0261) or Gastrin. Burimamide also has alpha-adrenoceptor blocking activity. Burimamide in combination with the H1-receptor antagonist Mepyramine (HY-B1281) shows anti-inflammatory activity in a rat paw edema model induced by Compound 48/80 (HY-115768) .

HY-B0371D

(S)-Terazosin	Adrenergic Receptor	Endocrinology
(S)-Terazosin is an active S-enantiomer of Terazosin. (S)-Terazosin is a potent and high-affinity *α-adrenoceptor* antagonist with K_i values of 3.91 nM, 0.79 nM and 1.16 nM for α1a, α1b and *α1d-adrenoceptor, respectively. (S)-Terazosin also has high-affinity for α2a, α2B* and *α2c*-adrenoceptor with K_i values of 729 nM, 3.5 nM and 46.4 nM, respectively .

HY-N3945R

Glaucine (Standard)	Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus	Infection Inflammation/Immunology
Glaucine (Standard) is the analytical standard of Glaucine. This product is intended for research and analytical applications. Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 μM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities .

HY-155297

Nebidrazine FLA-136	Histamine Receptor	Cardiovascular Disease
Nebidrazine is a centrally-acting hypotensive agent compared to clonidine, demonstrating weaker cardiovascular effects in rats. It induces dose-dependent hypotension and bradycardia when administered intracerebroventricularly (i.c.v.), with significantly lower sedative potential than clonidine in conscious rats. Yohimbine attenuates the cardiovascular effects of both Nebidrazine and clonidine, suggesting involvement of central alpha-autoreceptors sensitive to yohimbine. Unlike clonidine, Nebidrazine does not affect peripheral alpha-adrenoceptors in pithed rats, indicating a selective central mechanism. Chemical sympathectomy reduces Nebidrazine's cardiovascular effects more than clonidine's, and metiamide diminishes responses to both drugs, implicating central histamine receptors. These findings highlight Nebidrazine's distinct pharmacological profile and potential therapeutic application in managing hypertension through central alpha-autoreceptor stimulation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2833

Akuammigine	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Structural Classification Alkaloids Other Alkaloids Source classification Rubiaceae Plants Indole Alkaloids	Adrenergic Receptor
Akuammigine is an alkaloid that can be found in hook-bearing branch of Uncariarhynchophylla. Akuammigine is a is a very weak antagonist at pre- and postsynaptic *α-adrenoceptor* of the rat vas deferens .

HY-N4225

Aaptamine	Alkaloids Classification of Application Fields Animals Source classification Marine natural products Quinoline Alkaloids Sponge Disease Research Fields Endocrinology	Adrenergic Receptor
Aaptamine, a spongean alkaloid isolated from a sea sponge Aaptos aaptos, is a competitive antagonist of *α-adrenoceptor* and activates the p21 promoter in a p53-independent manner .

HY-N3945R

Glaucine (Standard)	Alkaloids Structural Classification other families Source classification Plants Isoquinoline Alkaloids Glaucium flavum Papaveraceae	Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus
Glaucine (Standard) is the analytical standard of Glaucine. This product is intended for research and analytical applications. Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 μM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities .

Cat. No.	Product Name	Chemical Structure

HY-B0431AS

Phenoxybenzamine-d5 hydrochloride
Phenoxybenzamine-d₅ (hydrochloride) is the deuterium labeled Phenoxybenzamine hydrochloride. Phenoxybenzamine hydrochloride is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine hydrochloride also shows antitumor activity[1][2][3].

HY-B0431S

Phenoxybenzamine-d5
Phenoxybenzamine-d₅ is the deuterium labeled Phenoxybenzamine[1]. Phenoxybenzamine is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine also shows antitumor activity[2][3].

HY-B0431AS1

Phenoxybenzamine (benzyl-2,3,4,5,6-d5) (hydrochloride)
Phenoxybenzamine (benzyl-2,3,4,5,6-d₅) (hydrochloride) is the deuterium labeled Phenoxybenzamine hydrochloride. Phenoxybenzamine hydrochloride is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine hydrochloride also shows antitumor activity[1][2][3].

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α-adrenoceptors

Inhibitors & Agonists

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Isotope-Labeled Compounds

Natural
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