Search Result
Results for "
2-Ar-1,2,3-triazole
" in MedChemExpress (MCE) Product Catalog:
10
Biochemical Assay Reagents
15
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-W113615
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-
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- HY-141941S
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-
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- HY-Y0219
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s-triazole; Pyrrodiazole
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Biochemical Assay Reagents
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Others
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1,2,4-Triazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
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- HY-Y0219A
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s-triazole sodium; Pyrrodiazole sodium
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Others
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Infection
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1,2,4-Triazole (sodium) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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-
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- HY-Y0219R
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Biochemical Assay Reagents
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Others
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1,2,4-Triazole (Standard) is the analytical standard of 1,2,4-Triazole. This product is intended for research and analytical applications. 1,2,4-Triazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-107870
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- HY-W012991
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Biochemical Assay Reagents
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Others
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1,2-Dihydro-3H-1,2,4-triazole-3-thione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
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- HY-W007685
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Biochemical Assay Reagents
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Others
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Methyl 1H-1,2,4-triazole-3-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W331786
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Bacterial
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Infection
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Ipconazole is a triazole fungicide that can be used for treating rice seed .
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- HY-163789
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ADC Linker
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Cancer
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Desthiobiotin-PEG3-triazole-DBCO-sulfo-Maleimide is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Desthiobiotin-PEG3-triazole-DBCO-sulfo-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .
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- HY-W586475
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Others
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Cancer
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Fluorescein-triazole-PEG5-DOTA is a radionuclide conjugate (RDC), which is capable of binding to a radionuclide. RDC has the ability to specifically target biomolecules and can be used in medical imaging or therapy .
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- HY-46369
-
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DNA/RNA Synthesis
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Others
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1-p-Chlorobenzyl-1,2,3-triazole-5′-O-DMT-dU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
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- HY-W098127S
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Isotope-Labeled Compounds
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Others
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Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate-d2 is the deuterium labeled Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate[1].
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- HY-W331786R
-
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Bacterial
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Infection
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Ipconazole (Standard) is the analytical standard of Ipconazole. This product is intended for research and analytical applications. Ipconazole is a triazole fungicide that can be used for treating rice seed .
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- HY-168006
-
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p97
ATP Synthase
|
Cancer
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NSC819701 is a triazole inhibitor of the p97 ATPase. NSC819701 inhibits the activity of p97 ATPase by binding to a specific site of p97 .
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-
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- HY-W019852
-
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Fungal
|
Infection
|
Flutriafol is a triazole fungicide with broad spectrum fungicidal activity.
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- HY-B2058
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Fungal
|
Infection
|
Triticonazole is a triazole pesticide. Triticonazole is an azole fungicide and shows endocrine disrupting activities .
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- HY-168005
-
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p97
ATP Synthase
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Cancer
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NSC799462 is a triazole inhibitor of p97 ATPase. NSC799462 inhibits p97 ATPase activity (IC50 = 15 nM) by binding to a specific site on p97 and causing local changes in the p97 structure .
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- HY-W019852R
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Fungal
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Infection
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Flutriafol (Standard) is the analytical standard of Flutriafol. This product is intended for research and analytical applications. Flutriafol is a triazole fungicide with broad spectrum fungicidal activity.
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- HY-163107
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Bacterial
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Infection
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Antimycobacterial agent-7 (compound 4) is a 1,2,4-triazole anti-tuberculosis agent (MIC: 2 μg/mL). Antimycobacterial agent-7 inhibits Mtb KatG and causes the accumulation of ROS in Mtb cells. ROS produces oxidative damage, leading to the death of Mtb .
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- HY-B0847
-
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Fungal
Reactive Oxygen Species
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Infection
|
Propiconazole is an orally active N-substituted triazole used as a fungicide. Propiconazole is a mouse liver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and developmental toxicities in experimental animals .
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- HY-B2058R
-
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Fungal
|
Infection
|
Triticonazole (Standard) is the analytical standard of Triticonazole. This product is intended for research and analytical applications. Triticonazole is a triazole pesticide. Triticonazole is an azole fungicide and shows endocrine disrupting activities .
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- HY-126677
-
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ADC Linker
PROTAC Linkers
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Cancer
|
Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA is a double claevable 3-unit and 4-unit PEG linker for antibody-agent-conjugation (ADC). Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA also is a PROTAC linker that can be used in the synthesis of PROTACs.
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- HY-B0847R
-
|
Fungal
Reactive Oxygen Species
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Infection
|
Propiconazole (Standard) is the analytical standard of Propiconazole. This product is intended for research and analytical applications. Propiconazole is an orally active N-substituted triazole used as a fungicide. Propiconazole is a mouse liver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and developmental toxicities in experimental animals .
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- HY-14273S
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BAL-4815-d4; RO-0094815-d4
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Fungal
Cytochrome P450
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Infection
|
Isavuconazole-d4 is a deuterium labeled Isavuconazole (BAL-4815). Isavuconazole is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi[1].
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- HY-76200
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UK-109496
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Fungal
Bacterial
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Infection
Cancer
|
Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .
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- HY-76200B
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UK-109496 camphorsulfonate
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Fungal
Bacterial
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Infection
|
Voriconazole (UK-109496) camphorsulfonate is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole camphorsulfonate exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .
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- HY-14273
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BAL-4815; RO-0094815
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Fungal
Cytochrome P450
Antibiotic
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Infection
|
Isavuconazole (BAL-4815) is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi. Isavuconazole inhibits ergosterol biosynthesis and results in the disruption of fungal membrane structure and function. Isavuconazole is a moderate inhibitor of CYP3A4.
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- HY-14273R
-
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Fungal
Cytochrome P450
Antibiotic
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Infection
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Isavuconazole (Standard) is the analytical standard of Isavuconazole. This product is intended for research and analytical applications. Isavuconazole (BAL-4815) is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi. Isavuconazole inhibits ergosterol biosynthesis and results in the disruption of fungal membrane structure and function. Isavuconazole is a moderate inhibitor of CYP3A4.
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- HY-161812
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Opioid Receptor
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Others
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MOR agonist-4 (2d) is a G protein signaling-biased Kappa opioid receptor (KOR) agonist with an EC50 value of 11 nM. MOR agonist-4 contains an electron withdrawing CF3 group and a bias factor of 38 based on triazole. MOR agonist-4 is used in the research of pruritis and analgesia .
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- HY-117766
-
|
Fungal
Cytochrome P450
|
Infection
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PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. PC945 is also a potent, tightly binding inhibitor of A. fumigatus sterol 14α-demethylase activity, CYP51A and CYP51B, with IC50s of 0.23 μM and 0.22 μM, respectively .
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- HY-B0101
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UK-49858
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Fungal
Antibiotic
Bacterial
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Infection
Cancer
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Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
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- HY-17514
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Itraconazole
Maximum Cited Publications
14 Publications Verification
R51211
|
Fungal
Hedgehog
Cytochrome P450
Autophagy
Antibiotic
Bacterial
|
Infection
Cancer
|
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
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- HY-B0101R
-
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Fungal
Antibiotic
Bacterial
|
Infection
Cancer
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Fluconazole (Standard) is the analytical standard of Fluconazole. This product is intended for research and analytical applications. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
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- HY-17514R
-
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Fungal
Hedgehog
Cytochrome P450
Autophagy
Antibiotic
Bacterial
|
Infection
Cancer
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Itraconazole (Standard) is the analytical standard of Itraconazole. This product is intended for research and analytical applications. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
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- HY-157532
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- HY-Y0219S1
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- HY-Y0688S
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-
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- HY-17373A
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SCH56592 hydrate
|
Fungal
Parasite
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Infection
Cancer
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Posaconazole hydrate is a broad-spectrum, second generation, triazole compound with antifungal activity.
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-
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- HY-17373
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-
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- HY-149367
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Apoptosis
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Cancer
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Anticancer agent 136 (compound 22), a C17-triazole analogue of Geldanamycin (GDM; HY-15230), has an IC50 of 3.38 μM for HDF and a Kd of 3.86 μM for Hsp90. Anticancer agent 136 is an apoptosis-inducing agent .
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- HY-144426
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Influenza Virus
|
Infection
|
Neuraminidase-IN-6 (Compound 5c) is a potent inhibitor of neuraminidase with an IC50 of 0.11 μM. Neuraminidase-IN-6 is a 1,3,4-triazole-3-acetamide derivative. Neuraminidase (NA) is an ideal target for the development of anti-influenza agents .
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- HY-B0101A
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-
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- HY-B0101B
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-
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- HY-W705791
-
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Fungal
|
Infection
|
Metconazole-d6 is the deuterium labeled Metconazole. Metconazole is a triazole fungicide agent.
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-
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- HY-106141
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UR 9825
|
Fungal
|
Infection
|
Albaconazole (UR 9825) is a broad-spectrum triazole and oral activity antifungal agent .
|
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- HY-A0277
-
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Bacterial
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Others
|
Cyproconazole is a triazole fungicide that is used agriculturally for protection of crops against a wide variety of fungal pathogens.
|
-
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- HY-147711
-
|
Glucosidase
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Metabolic Disease
|
α-Amylase/α-Glucosidase-IN-1 (compound 33) is a potent α-amylase/α-glucosidase inhibitor with IC50s of 2.01, 2.09 µM for α-amylase and α-glucosidase, respectively. Kinetic studies predict that α-Amylase/α-Glucosidase-IN-1 has the potential of anti hyperglycemia .
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- HY-B0851
-
|
Fungal
|
Infection
|
Triadimenol is a triazole fungicide and has been widely used in agriculture. Triadimenol has certain toxicity to animals .
|
-
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- HY-121161A
-
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Others
|
Others
|
Brassinazole is a selective triazole-type brassinosteroid (BR) biosynthesis inhibitor. Brassinazole is used for regulating plant growth and development .
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- HY-117771A
-
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DAGL
|
Metabolic Disease
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DO34 analog is a triazole DAGL(α) inhibitor extracted from patent WO2017096315 A1, compound 100.
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- HY-12772
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Itraconazole metabolite Hydroxy Itraconazole; R-63373
|
Fungal
Drug Metabolite
|
Others
|
Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
|
-
- HY-U00249
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R66905
|
Fungal
|
Infection
|
Saperconazole (R66905) is a broad-spectrum antifungal triazole and has potent activity against Aspergillus with an MIC90 of 0.19 mg/L.
|
-
- HY-14272
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BMS-207147; ER-30346
|
Fungal
|
Infection
Cancer
|
Ravuconazole (BMS-207147;ER-30346) is an orally available triazole antifungle agent that potently inhibits a wide range of fungi.
|
-
- HY-W749242
-
|
Fungal
|
Infection
|
Paclobutrazol-d4 is the deuterium labeled Paclobutrazol. Paclobutrazol is a triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins .
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-
- HY-126475
-
|
Others
|
Others
|
KSK213 is a 1,2,3-triazole-based Chlamydia infectivity inhibitor with high potency (EC50 ≤ 20 nM) against Chlamydia infectivity.
|
-
- HY-12772S
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R-63373-d8
|
Fungal
|
Others
|
Hydroxy Itraconazole-d8 is the deuterium labeled Hydroxy Itraconazole. Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
|
-
- HY-17373S
-
SCH 56592-d5
|
Isotope-Labeled Compounds
Fungal
|
Infection
|
Posaconazole-d5 is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity[1].
|
-
- HY-17373S1
-
SCH 56592-d4
|
Fungal
|
Infection
|
Posaconazole-d4 is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity[1].
|
-
- HY-17373R
-
SCH 56592 (Standard)
|
Fungal
Parasite
|
Infection
Cancer
|
Posaconazole (Standard) is the analytical standard of Posaconazole. This product is intended for research and analytical applications. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
|
-
- HY-121161
-
|
Cytochrome P450
|
Metabolic Disease
|
(Rac)-Brassinazole, triazole-type compound, is a brassinosteroid (BR) biosynthesis inhibitor. (Rac)-Brassinazole increases inhibition of CYP90B in BR biosynthesis
|
-
- HY-145864
-
|
VEGFR
|
Cancer
|
VEGFR-2-IN-12 (compound 6g), a 2-oxoquinoxalinyl-1,2,4-triazole, is a potent VEGFR-2 inhibitor with an IC50 of 0.037 µM. VEGFR-2-IN-12 shows high growth inhibition against MCF-7 cells (GI50=1.6 µM). VEGFR-2-IN-12 has antitumor activity .
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-
- HY-W700970
-
-
- HY-A0277R
-
|
Bacterial
|
Others
|
Cyproconazole (Standard) is the analytical standard of Cyproconazole. This product is intended for research and analytical applications. Cyproconazole is a triazole fungicide used in agriculture to protect crops from various fungal pathogens.
|
-
- HY-158968
-
|
MDM-2/p53
|
Cancer
|
MMs02943764 is a 1,2,4-triazole derivative with anticancer activity. MMs02943764 has significant antiproliferative effects on multiple cancer cell lines. PAC, a structural analog of MMs02943764, has significant cytotoxicity against the leukemia cell line K562 (IC50=35.264 μM), reduces the degradation of p53 by inhibiting Mdm2 and Pirh2, and induces K562 cell cycle arrest .
|
-
- HY-B0851S
-
|
Fungal
|
Infection
|
Triadimenol-d4 is the deuterium labeled Triadimenol[1]. Triadimenol is a triazole fungicide and has been widely used in agriculture. Triadimenol has certain toxicity to animals[2].
|
-
- HY-B0851R
-
|
Fungal
|
Infection
|
Triadimenol (Standard) is the analytical standard of Triadimenol. This product is intended for research and analytical applications. Triadimenol is a triazole fungicide and has been widely used in agriculture. Triadimenol has certain toxicity to animals .
|
-
- HY-148037
-
|
Proteasome
|
Cardiovascular Disease
|
Thrombin inhibitor 5 (compound 385) is a thrombin inhibitor, with IC50s ranging from 0.1 μM to 1 μM. Thrombin inhibitor 5 can be used for research of venous thromboembolism .
|
-
- HY-149518
-
|
EGFR
Apoptosis
|
Others
|
EGFR/BRAFV600E-IN-3 is a EGFR, BRAFV600E and EGFRT790M inhibitor with IC50 value of 57 nM, 68 nM and 9.70 nM. EGFR/BRAFV600E-IN-3 is an apoptotic inducer and also displays promising antioxidant activity .
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-
- HY-163674
-
|
Others
|
Inflammation/Immunology
|
Mincle agonist 1 (compound 1c) is a Mincle agonist. Mincle agonist 1 can promote IL-1β expression in BMDM cells. Mincle agonist 1 can be used in immune and inflammation related research .
|
-
- HY-135761
-
|
Fungal
Cholinesterase (ChE)
|
Infection
Neurological Disease
|
Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats .
|
-
- HY-117089
-
|
Fungal
|
Infection
|
Tetraconazole, a chiral triazole fungicide, is widely used for the prevention of plant disease in wheat fields . Tetraconazole alters the methionine and ergosterol biosynthesis pathways in Saccharomyces yeasts promoting changes on volatile derived compounds .
|
-
- HY-137989A
-
Voriconazole oxynitride hydrochloride
|
Drug Metabolite
|
Infection
|
Voriconazole N-oxide (Voriconazole oxynitride) (hydrochloride) is the main metabolite of Voriconazole (HY-76200) , a widely used triazole antibiotic (fungal). Voriconazole N-oxide (hydrochloride) provides information on the patient's drug metabolism capacity .
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-
- HY-14272R
-
|
Fungal
|
Infection
Cancer
|
Ravuconazole (Standard) is the analytical standard of Ravuconazole. This product is intended for research and analytical applications. Ravuconazole (BMS-207147;ER-30346) is an orally available triazole antifungle agent that potently inhibits a wide range of fungi.
|
-
- HY-W440950
-
|
Liposome
|
Others
|
Azide-PEG-Silane, MW 3400 can be used for surface modification through interaction between hydroxyl and ethoxyl silane. The azide group enables click reaction with alkyne to form a triazole bond. Reagent grade, for research use only.
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-
- HY-136403
-
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Others
|
Others
|
TIS108 is a triazole-type strigolactone biosynthetic inhibitor. TIS108 inhibits embryogenesis in Arabidopsis. TIS108 reduces the level of 2′-epi-5-deoxystrigol (epi-5DS) in rice .
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-
- HY-W440831
-
|
Biochemical Assay Reagents
Liposome
|
Others
|
DSPE-PEG-Azide, MW 1000 is a phospholipid with covalently attached polydisperse PEG. This polymer is commonly used for the preparation of long circulating liposomes. The azide moiety is reactive with alkyne to form a stable triazole bond. Reagent grade, for research use only.
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-
- HY-163005
-
|
Glucosidase
|
Metabolic Disease
|
α-Glucosidase-IN-43 (compound AS14) is an α-glucosidase inhibitor (IC50: 4.32 μM) with acute hypoglycemic activity. α-Glucosidase-IN-43 exhibits safety and in vivo efficacy, is nontoxic to normal mouse fibroblasts, and is able to rescue streptozotocin (HY-13753)-induced diabetic rats. α-Glucosidase-IN-43 can be used to study postprandial hyperglycemia in diabetic patients .
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-
- HY-N7497
-
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Others
|
Others
|
Protoescigenin is the main aglycone of horse chestnut saponin mixture known as escin. Protoescigenin is selected as substrate for exploratory chemistry towards selective protection, followed by propargyl ether formation and subsequent condensation with azido-monosaccharides, to obtain novel triazole linked conjugates of the triterpene .
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-
- HY-138665
-
|
Prostaglandin Receptor
|
Endocrinology
|
HHS-0701, a sulfur-triazole exchange (SuTEx) ligand, is a potent tyrosine-reactive prostaglandin reductase 2 (PTGR2) inhibitor. HHS-0701 blocks PTGR2 metabolism of the lipid substrate 15-Keto-PGE2 .
|
-
- HY-W540023
-
|
ADC Linker
|
Cancer
|
Endo-BCN-Fmoc-L-Lysine is a linker containing the lyophilic bidentate macrocyclic ligand endo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts.
|
-
- HY-128945
-
|
ADC Linker
|
Inflammation/Immunology
Cancer
|
CL2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker .
|
-
- HY-Y0219S
-
-
- HY-W282615
-
|
Bacterial
|
Infection
|
Antibacterial agent 117, triazole derivative, is an antibacterial agent. Antibacterial agent 117 has against R. prowazekii MetAP1 (RpMetAP1) activity with an IC50 value of 15 μM. Antibacterial agent 117 also inhibits rickettsial growth and can be used for the research of infection .
|
-
- HY-100373
-
BAL8557-002
|
Fungal
|
Infection
|
Isavuconazonium sulfate (BAL8557-002) is an orally active broad-spectrum antifungal molecule. Isavuconazonium sulfate is a precursor of the triazole antifungal active molecule Isavuconazole. Isavuconazonium sulfate can be used in the study of invasive aspergillosis, mucormycosis, blastomycosis, and Acanthamoeba keratitis .
|
-
- HY-135761S
-
|
Fungal
Cholinesterase (ChE)
|
Infection
|
Penconazole-d7 is the deuterium labeled Penconazole[1]. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[2][3].
|
-
- HY-135761R
-
|
Fungal
Cholinesterase (ChE)
|
Infection
Neurological Disease
|
Penconazole (Standard) is the analytical standard of Penconazole. This product is intended for research and analytical applications. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats .
|
-
- HY-117089R
-
|
Fungal
|
Infection
|
Tetraconazole (Standard) is the analytical standard of Tetraconazole. This product is intended for research and analytical applications. Tetraconazole, a chiral triazole fungicide, is widely used for the prevention of plant disease in wheat fields . Tetraconazole alters the methionine and ergosterol biosynthesis pathways in Saccharomyces yeasts promoting changes on volatile derived compounds .
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-
- HY-128945A
-
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ADC Linker
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Inflammation/Immunology
Cancer
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CL2A TFA is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A TFA is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker .
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-
- HY-123037
-
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Fungal
|
Infection
|
Triadimefon is a triazole fungicide used to control powdery mildew, rusts, and other fungal pests on grains, fruit and vegetable crops, turf, shrubs, and trees. Triadimefon inhibits lanosterol 14α-demethylase, interfering with oxidative demethylation reactions in the ergosterol biosynthesis pathway of fungi, and also blocks gibberellin biosynthesis.
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-
- HY-155011
-
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Others
|
Others
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MB076 is a novel heterocyclic triazole with improved plasma stability. MB076 inhibits seven different Class C Acinetobacter-derived cephalosporinases (ADCs) β-lactamase variants with Ki values < 1 μM. MB076 acts synergistically in combination with multiple cephalosporins to restore pBCSK(−) susceptibility .
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- HY-B0853
-
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Fungal
|
Infection
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Paclobutrazol is a triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins. Paclobutrazol also has antifungal activities. Paclobutrazol, transported acropetally in plants, can also suppress the synthesis of abscisic acid and induce chilling tolerance in plants. Paclobutrazol is typically used to support research on the role of gibberellins in plant biology .
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-
- HY-15660
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KP-103
|
Fungal
|
Infection
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Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively . Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species .
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-
- HY-146079
-
|
Fungal
|
Infection
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Antifungal agent 31 (compound 12) is a potent and orally active triazole antifungal agents with a pyrrolotriazinone scaffold. Antifungal agent 31 shows antifungal activity against Candida spp. and filamentous fungi. Antifungal agent 31 significantly reduced mortality rates and kidney fungal burden in two murine models of lethal systemic infections .
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-
- HY-W440991
-
|
Liposome
|
Cancer
|
DOPE-PEG-Amine (MW 2000) is a polydisperse PEG covalently attached to a phospholipid. The polymer is an amphiphilic molecule with hydrophobic fatty acid chains and hydrophilic PEG head which enables lipid bilayer or micelle formation in water. The phospholipid PEG can be used to prepare liposome or nanoparticles for targeted drug delivery and is reactive with alkyne to form a triazole ring.
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-
- HY-W440949
-
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Biochemical Assay Reagents
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Others
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Azide-PEG-Silane, MW 2000 is a click reagent which can react with a terminal alkyne via CuAAC or with a cyclooctyne (DBCO/BCN) via SPAAC to form a triazole bond. Silane is a surface modification moiety which can react with hydroxyl group of surface, such as glass, nanoparticles, etc. Reagent grade, for research use only.
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-
- HY-W440951
-
|
Biochemical Assay Reagents
|
Others
|
Azide-PEG-Silane, MW 5000 is a heterobifunctional polyPEG for surface grafting through reaction between hydroxyl and ethoxyl silane. The polymer through its azide moiety can react with a terminal alkyne via CuAAC or with a cyclooctyne (DBCO/BCN) via SPAAC to form a covalent triazole bond. Reagent grade, for research use only.
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-
- HY-76200S
-
UK-109496-d3
|
Fungal
|
Infection
|
Voriconazole-d3 is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes[1][2].
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-
- HY-B0101S
-
UK-49858-d4
|
Fungal
Antibiotic
|
Infection
|
Fluconazole-d4 is the deuterium labeled Fluconazole. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL[1].
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-
- HY-W457950
-
|
Ligands for E3 Ligase
|
Cancer
|
Thalidomide-5-propargyl is a propargyl-modified Thalidomide (HY-14658), that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-5-propargyl use alkynyl group at the end to be directly used in the synthesis of triazoles in the synthesis of PROTAC molecules, and is a key intermediate in the synthesis of PROTAC molecules based on CRBN design .
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-
Cat. No. |
Product Name |
Type |
-
- HY-Y0219
-
s-triazole; Pyrrodiazole
|
Biochemical Assay Reagents
|
1,2,4-Triazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
- HY-Y0219R
-
|
Biochemical Assay Reagents
|
1,2,4-Triazole (Standard) is the analytical standard of 1,2,4-Triazole. This product is intended for research and analytical applications. 1,2,4-Triazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
- HY-107870
-
|
Chelators
|
1,2,4-Triazole-3-carboxylic acid, 97% is a biochemical assay reagent.
|
-
- HY-W012991
-
|
Biochemical Assay Reagents
|
1,2-Dihydro-3H-1,2,4-triazole-3-thione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W007685
-
|
Biochemical Assay Reagents
|
Methyl 1H-1,2,4-triazole-3-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-163789
-
|
Biochemical Assay Reagents
|
Desthiobiotin-PEG3-triazole-DBCO-sulfo-Maleimide is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Desthiobiotin-PEG3-triazole-DBCO-sulfo-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .
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-
- HY-W700970
-
|
Carbohydrates
|
1,4-Phenylenebismaleimide is a biochemical assay reagent.
|
-
- HY-W440831
-
|
Drug Delivery
|
DSPE-PEG-Azide, MW 1000 is a phospholipid with covalently attached polydisperse PEG. This polymer is commonly used for the preparation of long circulating liposomes. The azide moiety is reactive with alkyne to form a stable triazole bond. Reagent grade, for research use only.
|
-
- HY-W440949
-
|
Drug Delivery
|
Azide-PEG-Silane, MW 2000 is a click reagent which can react with a terminal alkyne via CuAAC or with a cyclooctyne (DBCO/BCN) via SPAAC to form a triazole bond. Silane is a surface modification moiety which can react with hydroxyl group of surface, such as glass, nanoparticles, etc. Reagent grade, for research use only.
|
-
- HY-W440951
-
|
Drug Delivery
|
Azide-PEG-Silane, MW 5000 is a heterobifunctional polyPEG for surface grafting through reaction between hydroxyl and ethoxyl silane. The polymer through its azide moiety can react with a terminal alkyne via CuAAC or with a cyclooctyne (DBCO/BCN) via SPAAC to form a covalent triazole bond. Reagent grade, for research use only.
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-76200
-
UK-109496
|
Microorganisms
Source classification
|
Fungal
Bacterial
|
Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .
|
-
-
- HY-B0101
-
UK-49858
|
Microorganisms
Source classification
|
Fungal
Antibiotic
Bacterial
|
Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
|
-
-
- HY-17514
-
Itraconazole
Maximum Cited Publications
14 Publications Verification
R51211
|
Microorganisms
Source classification
|
Fungal
Hedgehog
Cytochrome P450
Autophagy
Antibiotic
Bacterial
|
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
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-
-
- HY-N7497
-
-
-
- HY-B0101R
-
|
Microorganisms
Source classification
|
Fungal
Antibiotic
Bacterial
|
Fluconazole (Standard) is the analytical standard of Fluconazole. This product is intended for research and analytical applications. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .
|
-
-
- HY-17514R
-
|
Microorganisms
Source classification
|
Fungal
Hedgehog
Cytochrome P450
Autophagy
Antibiotic
Bacterial
|
Itraconazole (Standard) is the analytical standard of Itraconazole. This product is intended for research and analytical applications. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
|
-
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-14273S
-
|
Isavuconazole-d4 is a deuterium labeled Isavuconazole (BAL-4815). Isavuconazole is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi[1].
|
-
-
- HY-Y0688S
-
|
1H-Benzotriazole-4,5,6,7-d4 is the deuterium labeled 1H-Benzo[d][1,2,3]triazole[1].
|
-
-
- HY-12772S
-
|
Hydroxy Itraconazole-d8 is the deuterium labeled Hydroxy Itraconazole. Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
|
-
-
- HY-17373S
-
|
Posaconazole-d5 is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity[1].
|
-
-
- HY-17373S1
-
|
Posaconazole-d4 is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity[1].
|
-
-
- HY-141941S
-
|
Triazole Lactic Acid- 13C2, 15N3 is the 13C and 15N labeled Triazole Lactic Acid[1].
|
-
-
- HY-W098127S
-
|
Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate-d2 is the deuterium labeled Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate[1].
|
-
-
- HY-Y0219S1
-
|
NSC 83128-d3 is the deuterium labeled NSC 83128[1].
|
-
-
- HY-W705791
-
|
Metconazole-d6 is the deuterium labeled Metconazole. Metconazole is a triazole fungicide agent.
|
-
-
- HY-W749242
-
|
Paclobutrazol-d4 is the deuterium labeled Paclobutrazol. Paclobutrazol is a triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins .
|
-
-
- HY-B0851S
-
|
Triadimenol-d4 is the deuterium labeled Triadimenol[1]. Triadimenol is a triazole fungicide and has been widely used in agriculture. Triadimenol has certain toxicity to animals[2].
|
-
-
- HY-Y0219S
-
|
NSC 83128- 13C2, 15N3 is the 13C and 15N labeled NSC 83128[1].
|
-
-
- HY-135761S
-
|
Penconazole-d7 is the deuterium labeled Penconazole[1]. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[2][3].
|
-
-
- HY-76200S
-
|
Voriconazole-d3 is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes[1][2].
|
-
-
- HY-B0101S
-
|
Fluconazole-d4 is the deuterium labeled Fluconazole. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL[1].
|
-
Cat. No. |
Product Name |
|
Classification |
-
- HY-W440831
-
|
|
Azide
|
DSPE-PEG-Azide, MW 1000 is a phospholipid with covalently attached polydisperse PEG. This polymer is commonly used for the preparation of long circulating liposomes. The azide moiety is reactive with alkyne to form a stable triazole bond. Reagent grade, for research use only.
|
-
- HY-W540023
-
|
|
BCN
|
Endo-BCN-Fmoc-L-Lysine is a linker containing the lyophilic bidentate macrocyclic ligand endo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts.
|
Cat. No. |
Product Name |
|
Classification |
-
- HY-46369
-
|
|
Nucleoside Phosphoramidites
|
1-p-Chlorobenzyl-1,2,3-triazole-5′-O-DMT-dU Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.
|
-
- HY-W440950
-
|
|
Pegylated Lipids
|
Azide-PEG-Silane, MW 3400 can be used for surface modification through interaction between hydroxyl and ethoxyl silane. The azide group enables click reaction with alkyne to form a triazole bond. Reagent grade, for research use only.
|
-
- HY-W440991
-
|
|
Pegylated Lipids
|
DOPE-PEG-Amine (MW 2000) is a polydisperse PEG covalently attached to a phospholipid. The polymer is an amphiphilic molecule with hydrophobic fatty acid chains and hydrophilic PEG head which enables lipid bilayer or micelle formation in water. The phospholipid PEG can be used to prepare liposome or nanoparticles for targeted drug delivery and is reactive with alkyne to form a triazole ring.
|
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