TIS108

Cat. No.: HY-136403 Purity: 99.92%: Data Sheet
SDS

COA
Handling Instructions Technical Support

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TIS108 is a triazole-type strigolactone biosynthesis inhibitor. TIS108 inhibits Arabidopsis embryogenesis and root hair growth, and promotes shoot branching. TIS108 can also increase the gibberellin content in Gastrodia elata. TIS108 can be used in the research of plant growth and development as well as plant responses to the environment.

For research use only. We do not sell to patients.

TIS108 Chemical Structure

CAS No. : 1315459-30-3

Size	Price	Stock	Quantity
5 mg	USD 116	In-stock	Estimated Time of Arrival: May 20
10 mg	USD 186	In-stock	Estimated Time of Arrival: May 20
25 mg	USD 372	In-stock	Estimated Time of Arrival: May 20
50 mg	USD 595	In-stock	Estimated Time of Arrival: May 20
100 mg	USD 950	In-stock	Estimated Time of Arrival: May 20
200 mg		Get quote
500 mg		Get quote

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Description

In Vitro

TIS108 (0-1.6 μM; 0-14 days) can inhibit the number of somatic embryos formed in Arabidopsis explants, partially reverse the up-regulating effect of GR24 (HY-129038) on the expression of ARF5, ARF8, ARF10, and ARF16 genes, and simultaneously affect the expression of WUS and SERK1 genes^[1].
TIS108 (1-3 μM) can increase the number of shoot branches, inhibit root hair elongation, and promote the expression of MAX3 and MAX4 in wild-type Arabidopsis^[2].
TIS108 (10 μM; 14 days) can significantly increase the gibberellin content and reduce the level of GeCYP714A1 in Gastrodia elata tubers^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[3]

Cell Line:	Gastrodia elata tubers
Concentration:	10 μM
Incubation Time:	14 days
Result:	Inhibited the level of GeCYP714A1.

Molecular Weight

335.40

Formula

C₂₀H₂₁N₃O₂

CAS No.

1315459-30-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC=C1)C(N2N=CN=C2)CCCCOC3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 125 mg/mL (372.69 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9815 mL	14.9076 mL	29.8151 mL
5 mM	0.5963 mL	2.9815 mL	5.9630 mL
10 mM	0.2982 mL	1.4908 mL	2.9815 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (246 KB) HNMR (258 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Elhiti M, et al. Synthetic Strigolactone GR24 Improves Arabidopsis Somatic Embryogenesis through Changes in Auxin Responses. Plants (Basel). 2021 Dec 10;10(12):2720. [Content Brief]

[2]. Ito S, et al. Effects of strigolactone-biosynthesis inhibitor TIS108 on Arabidopsis. Plant Signal Behav. 2013 May;8(5):e24193. [Content Brief]

[3]. Zhang YX, et al. [Influence of Tis108 on GA content and expression of key enzyme GeCYP714A1 involved in GA deactivation of Gastrodia elata]. Zhongguo Zhong Yao Za Zhi. 2024 Aug;49(15):4007-4014. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9815 mL	14.9076 mL	29.8151 mL	74.5379 mL
	5 mM	0.5963 mL	2.9815 mL	5.9630 mL	14.9076 mL
	10 mM	0.2982 mL	1.4908 mL	2.9815 mL	7.4538 mL
	15 mM	0.1988 mL	0.9938 mL	1.9877 mL	4.9692 mL
	20 mM	0.1491 mL	0.7454 mL	1.4908 mL	3.7269 mL
	25 mM	0.1193 mL	0.5963 mL	1.1926 mL	2.9815 mL
	30 mM	0.0994 mL	0.4969 mL	0.9938 mL	2.4846 mL
	40 mM	0.0745 mL	0.3727 mL	0.7454 mL	1.8634 mL
	50 mM	0.0596 mL	0.2982 mL	0.5963 mL	1.4908 mL
	60 mM	0.0497 mL	0.2485 mL	0.4969 mL	1.2423 mL
	80 mM	0.0373 mL	0.1863 mL	0.3727 mL	0.9317 mL
	100 mM	0.0298 mL	0.1491 mL	0.2982 mL	0.7454 mL

TIS108 Related Classifications

Others

Keywords:

TIS1081315459-30-3TIS 108TIS-108Phytohormonestrigolactoneembryogenesisepi-5DSGastrodia elataArabidopsisInhibitorinhibitorinhibit

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TIS108

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