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TIS108 is a triazole-type strigolactone biosynthesis inhibitor. TIS108 inhibits Arabidopsis embryogenesis and root hair growth, and promotes shoot branching. TIS108 can also increase the gibberellin content in Gastrodia elata. TIS108 can be used in the research of plant growth and development as well as plant responses to the environment.

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TIS108 Chemical Structure

TIS108 Chemical Structure

CAS No. : 1315459-30-3

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5 mg USD 116 In-stock
10 mg USD 186 In-stock
25 mg USD 372 In-stock
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Description

TIS108 is a triazole-type strigolactone biosynthesis inhibitor. TIS108 inhibits Arabidopsis embryogenesis and root hair growth, and promotes shoot branching. TIS108 can also increase the gibberellin content in Gastrodia elata. TIS108 can be used in the research of plant growth and development as well as plant responses to the environment[1][2][3].

In Vitro

TIS108 (0-1.6 μM; 0-14 days) can inhibit the number of somatic embryos formed in Arabidopsis explants, partially reverse the up-regulating effect of GR24 (HY-129038) on the expression of ARF5, ARF8, ARF10, and ARF16 genes, and simultaneously affect the expression of WUS and SERK1 genes[1].
TIS108 (1-3 μM) can increase the number of shoot branches, inhibit root hair elongation, and promote the expression of MAX3 and MAX4 in wild-type Arabidopsis[2].
TIS108 (10 μM; 14 days) can significantly increase the gibberellin content and reduce the level of GeCYP714A1 in Gastrodia elata tubers[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR[3]

Cell Line: Gastrodia elata tubers
Concentration: 10 μM
Incubation Time: 14 days
Result: Inhibited the level of GeCYP714A1.
Molecular Weight

335.40

Formula

C20H21N3O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC=C1)C(N2N=CN=C2)CCCCOC3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (372.69 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9815 mL 14.9076 mL 29.8151 mL
5 mM 0.5963 mL 2.9815 mL 5.9630 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: 99.92%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9815 mL 14.9076 mL 29.8151 mL 74.5379 mL
5 mM 0.5963 mL 2.9815 mL 5.9630 mL 14.9076 mL
10 mM 0.2982 mL 1.4908 mL 2.9815 mL 7.4538 mL
15 mM 0.1988 mL 0.9938 mL 1.9877 mL 4.9692 mL
20 mM 0.1491 mL 0.7454 mL 1.4908 mL 3.7269 mL
25 mM 0.1193 mL 0.5963 mL 1.1926 mL 2.9815 mL
30 mM 0.0994 mL 0.4969 mL 0.9938 mL 2.4846 mL
40 mM 0.0745 mL 0.3727 mL 0.7454 mL 1.8634 mL
50 mM 0.0596 mL 0.2982 mL 0.5963 mL 1.4908 mL
60 mM 0.0497 mL 0.2485 mL 0.4969 mL 1.2423 mL
80 mM 0.0373 mL 0.1863 mL 0.3727 mL 0.9317 mL
100 mM 0.0298 mL 0.1491 mL 0.2982 mL 0.7454 mL
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Product Name:
TIS108
Cat. No.:
HY-136403
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