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Results for "

4-4-20

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Fluorescent Dye (1) MicroRNA (4) TSH Receptor (1)
By Research Areas:	Cancer (5)
Oligonucleotides:	miRNA mimics (1) miRNA agomirs (1) miRNA antagomirs (1) MicroRNAs (4) miRNA inhibitors (1)

Inhibitors & Agonists

Targets Recommended: CD20

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Fluorescein-6-isothiocyanate	Fluorescent Dye	Others
Fluorescein-6-isothiocyanate is a fluorescent isomeric haptenic probes with K_ds of 8.74, 2.72 and 1.88 for N-Acetyl-L-Lysine, normal mouse IgG and 4-4-20, respectively .

NCATS-SM4420	TSH Receptor	Cancer
NCATS-SM4420 (Compound A35) is an orally active thyroid-stimulating hormone receptor (TSHR) ligand that inhibits the proliferation of MDA-T32 and MDA-T85 cells in vitro (IC₅₀ values of 0.71 μM and 0.38 μM, respectively) and suppresses metastasis of MDA-T85F1 in mice. NCATS-SM4420 holds promise for research in the field of thyroid cancer .

*hsa-miR-4420* mimic**	MicroRNA	Cancer
hsa-miR-4420 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-4420 mimic hsa-miR-4420 mimic

*hsa-miR-4420* inhibitor**	MicroRNA	Cancer
hsa-miR-4420 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-4420 inhibitor hsa-miR-4420 inhibitor

*hsa-miR-4420* agomir**	MicroRNA	Cancer
hsa-miR-4420 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-4420 agomir hsa-miR-4420 agomir

*hsa-miR-4420* antagomir**	MicroRNA	Cancer
hsa-miR-4420 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-4420 antagomir hsa-miR-4420 antagomir

Cat. No.	Product Name	Type

Fluorescein-6-isothiocyanate	Fluorescent Dyes/Probes
Fluorescein-6-isothiocyanate is a fluorescent isomeric haptenic probes with K_ds of 8.74, 2.72 and 1.88 for N-Acetyl-L-Lysine, normal mouse IgG and 4-4-20, respectively .

Cat. No.	Product Name		Classification

*hsa-miR-4420* mimic**		MicroRNAs miRNA mimics
hsa-miR-4420 mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

*hsa-miR-4420* inhibitor**		MicroRNAs miRNA inhibitors
hsa-miR-4420 inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

*hsa-miR-4420* agomir**		MicroRNAs miRNA agomirs
hsa-miR-4420 agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

*hsa-miR-4420* antagomir**		MicroRNAs miRNA antagomirs
hsa-miR-4420 antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

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