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ADAMTS-5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADAMTS (7) AP-1 (1) Biochemical Assay Reagents (1) MMP (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Inflammation/Immunology (4) Metabolic Disease (2)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

11

Inhibitors & Agonists

4

Peptides

1

Antibodies

2

Oligonucleotides

Targets Recommended: ADAMTS

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

ADAMTS-5 Inhibitor 3 Publications Verification	ADAMTS	Inflammation/Immunology
ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC₅₀ of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1) .

ADAMTS-5-IN-3	ADAMTS	Metabolic Disease Inflammation/Immunology
ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of *ADAMTS-5* and *ADAMTS-4* with IC₅₀s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis .

ADAMTS-5-IN-2	ADAMTS	Inflammation/Immunology
ADAMTS-5-IN-2 (compound 25) is a potent *ADAMTS-5* inhibitor with an IC₅₀ value of 0.71 µM. ADAMTS-5-IN-2 has the potential for the research of modifying osteoarthritis .

5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA	ADAMTS	Others
5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA is a substrate for *ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5* activity .

Aldumastat GLPG1972; S201086	ADAMTS	Metabolic Disease
Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active *ADAMTS-5* (IC₅₀=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC₅₀=156 nM). Aldumastat has anticatabolic activity and is used for osteoarthritis research .

T-5224 70+ Cited Publications	AP-1 MMP	Others
T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

Adamts5 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Adamts5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adamts5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Adamts5 Mouse Pre-designed siRNA Set A Adamts5 Mouse Pre-designed siRNA Set A

ADAMTS5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ADAMTS5 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAMTS5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ADAMTS5 Human Pre-designed siRNA Set A ADAMTS5 Human Pre-designed siRNA Set A

5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2	ADAMTS	Others
5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 is a substrate for *ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5* activity .

AGG-523 PF-5212371	ADAMTS	Inflammation/Immunology
AGG-523 (PF-5212371) is a reversible, non-hydroxamate, zinc-binding selective aggrecanase 1 (ADAMTS4) and aggrecanase 2 (ADAMTS5) inhibitor. AGG-523 can be used for the study of osteoarthritis (OA) .

WAAG-3R TFA	Biochemical Assay Reagents	Others
WAAG-3R TFA is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay . (Ex/Em = 340/420 nm)

Cat. No.	Product Name	Target	Research Area

5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA	ADAMTS	Others
5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA is a substrate for *ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5* activity .

WAAG-3R TFA	Biochemical Assay Reagents	Others
WAAG-3R TFA is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay . (Ex/Em = 340/420 nm)

5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2	ADAMTS	Others
5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 is a substrate for *ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5* activity .

WAAG-3R	Peptides	Others
WAAG-3R is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay . (Ex/Em = 340/420 nm)

Cat. No.	Compare	Product Name	Application	Reactivity

	ADAMTS5 Antibody A disintegrin and metalloproteinase with thrombospondin motifs 5; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 5; A Disintigrin And Metalloproteinase with ThromboSpondin motif-5; ADAM metallopeptidase with thrombospondin type 1 motif 5; ADAM TS 11; ADAM TS 5; ADAM TS5; ADAMTS 11; ADAMTS 5; ADAMTS11; ADMP 2; ADMP2; Aggrecanase 2; aggrecanase-2; FLJ36738; Implantin; ThromboSpondin motif-5.	WB, ICC/IF, FC	Human, Mouse, Rat
	ADAMTS5 Antibody is an unconjugated, approximately 102 kDa, rabbit-derived, anti-ADAMTS5 monoclonal antibody. ADAMTS5 Antibody can be used for: WB, IF-Cell, FC expriments in human, mouse, rat background without labeling.

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