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Results for "

ADAMTS5

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

4

Peptides

1

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-114996
    ADAMTS-5 Inhibitor
    3 Publications Verification

    		 ADAMTS Inflammation/Immunology
    ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC50 of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1) .
    ADAMTS-5 Inhibitor
  • HY-135710
    ADAMTS-5-IN-2

    		ADAMTS Inflammation/Immunology
    ADAMTS-5-IN-2 (compound 25) is a potent ADAMTS-5 inhibitor with an IC50 value of 0.71 µM. ADAMTS-5-IN-2 has the potential for the research of modifying osteoarthritis .
    ADAMTS-5-IN-2
  • HY-145061
    ADAMTS-5-IN-3

    		ADAMTS Metabolic Disease Inflammation/Immunology
    ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis .
    ADAMTS-5-IN-3
  • HY-P10398
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA

    		ADAMTS Others
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA is a substrate for ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5 activity .
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA
  • HY-137430
    Aldumastat

    GLPG1972; S201086

    		 ADAMTS Metabolic Disease
    Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active ADAMTS-5 (IC50=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC50=156 nM). Aldumastat has anticatabolic activity and is used for osteoarthritis research .
    Aldumastat
  • HY-12270
    T-5224
    65+ Cited Publications

    		 AP-1 MMP Others
    T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .
    T-5224
  • HY-P5419A
    WAAG-3R TFA

    		Biochemical Assay Reagents Others
    WAAG-3R TFA is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay . (Ex/Em = 340/420 nm)
    WAAG-3R TFA
  • HY-RS00305
    ADAMTS5 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ADAMTS5 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAMTS5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ADAMTS5 Human Pre-designed siRNA Set A
    ADAMTS5 Human Pre-designed siRNA Set A
  • HY-160822
    AGG-523

    PF-5212371

    		 ADAMTS Inflammation/Immunology
    AGG-523 (PF-5212371) is a reversible, non-hydroxamate, zinc-binding selective aggrecanase 1 (ADAMTS4) and aggrecanase 2 (ADAMTS5) inhibitor. AGG-523 can be used for the study of osteoarthritis (OA) .
    AGG-523
  • HY-P10468
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2

    		ADAMTS Others
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 is a substrate for ADAMTS-4/ADAMTS-5, and can be used to detect ADAMTS-4 or ADAMTS-5 activity .
    5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2

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