AGT

By Targets:	Angiotensin Receptor (1) Apolipoprotein (1) Apoptosis (2) DNA/RNA Synthesis (1) HCV (1) Insulin Receptor (1) PKC (1) Small Interfering RNA (siRNA) (1) Toll-like Receptor (TLR) (6)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (6) Metabolic Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (1) CpG ODNs (6) Antisense Oligonucleotides (3) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99530

Valanafusp alfa AGT-181; HIRMAb-IDUA	Insulin Receptor	Metabolic Disease
Valanafusp alfa (AGT-181) is a chimeric monoclonal antibody that fuses human α-L-iduronidase (IDUA) and targets the human insulin receptor (HIR). Valanafusp alfa has brain penetrating properties, making it useful for research on mucopolysaccharidosis type I (MPS I) .

HY-W002585

O6-Benzylguanine 1 Publications Verification	DNA/RNA Synthesis Apoptosis	Cancer
O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase *(MGMT/AGT)* inhibitor. O6-Benzylguanine acts as an AGT substrate, which transfers its benzyl group to the AGT cysteine residue, thereby irreversibly inactivating AGT and preventing DNA repair. O6-Benzylguanine induces tumor cell apoptosis. Antineoplastic activity .

HY-RS00466

AGT Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AGT Human Pre-designed siRNA Set A contains three designed siRNAs for AGT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AGT Human Pre-designed siRNA Set A AGT Human Pre-designed siRNA Set A

HY-P5939

Angiotensinogen (1-13) (human)	Angiotensin Receptor	Cardiovascular Disease
Angiotensinogen (1-13) (human) is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides .

HY-150740

ODN 21595	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 21595 is a Guanine-Modified TLR7 and TLR9 inhibitor. ODN 21595 inhibits the release of IFN-α and IL-6 with no cytotoxic. ODN 21595 reduces the expression of CD86 and HLA-DR. ODN 21595 has the potential for the research of systemic lupus erythematosus (SLE) .

HY-150738

ODN 2088	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 2088 is a potent TLR3, TLR7 and TLR9 inhibitor. ODN 2088 shows no cytotoxic. ODN 2088 inhibits the release of IFN-α and IL-6 .

HY-150736

ODN 20844	Toll-like Receptor (TLR)	Infection Inflammation/Immunology
ODN 20844, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a TLR7 and TLR9 (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 20844 disrupts TLR7- and TLR9-mediated immune cell immune responses. ODN 20844 sequence: 5'-TCCTGGCGc7GGGAAGT-3' .

HY-150744

ODN 24888	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 24888 is an guanine-modified inhibitory oligonucleotides (INH-ODN), shows potent inhibition on TLR7/TLR9-mediated signaling. ODN 24888 impairs IFN-α level and NF-κB activation, inhibits IL-6 release. ODN 24888 involves in immune and inflammatory responses, can be used as a vaccine adjuvant .

HY-150215

ODN 105870	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 105870, a G-modified inhibitory oligonucleotide (INH-ODN), is a selective TLR7 inhibitor. ODN 105870 can be uesd for inflammatory immune responses research .

HY-150216

ODN 105871	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 105871, a G-modified inhibitory oligonucleotide (INH-ODN), is a selective TLR7 inhibitor. ODN 105871 can be uesd for inflammatory immune responses research .

HY-148413

Aprinocarsen sodium 1 Publications Verification ISIS 3521 sodium	PKC	Cancer
Aprinocarsen (ISIS 3521) sodium, a specific antisense oligonucleotide inhibitor of protein kinase C-alpha (PKC-α). Aprinocarsen sodium is a 20-mer oligonucleotide, it regulates cell differentiation and proliferation. Aprinocarsen sodium inhibits the growth of human tumor cell lines in nude mice. Aprinocarsen sodium shows the value as a chemotherapeutic compound of human cancers .

HY-143230

Custirsen OGX-011	Apoptosis	Cancer
Custirsen is a highly specific antisense oligonucleotide that inhibits the production of clusterin , an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance.

HY-108764

Mipomersen sodium ISIS 301012	Apolipoprotein HCV	Metabolic Disease
Mipomersen sodium (ISIS 301012) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen sodium can be used for the research of homozygous familial hypercholesterolemia (HoFH) .

Cat. No.	Product Name	Target	Research Area

HY-P5939

Angiotensinogen (1-13) (human)	Angiotensin Receptor	Cardiovascular Disease
Angiotensinogen (1-13) (human) is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides .

Cat. No.	Product Name	Target	Research Area

HY-P99530

Valanafusp alfa AGT-181; HIRMAb-IDUA	Insulin Receptor	Metabolic Disease
Valanafusp alfa (AGT-181) is a chimeric monoclonal antibody that fuses human α-L-iduronidase (IDUA) and targets the human insulin receptor (HIR). Valanafusp alfa has brain penetrating properties, making it useful for research on mucopolysaccharidosis type I (MPS I) .

Species:	Human (2) Rat (1) Mouse (1)
Tag:	His (4)
Source:	HEK293 (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P73651

	Serpin A8/Angiotensinogen Protein, Rat (HEK293, His) Angiotensinogen; Serpin A8; AGT; SERPINA8	Rat	HEK293
	Serpin A8 (or angiotensinogen) is a key regulator of the renin-angiotensin system, affecting blood pressure, fluid and electrolyte balance.As a vasoconstrictor, it directly affects vascular smooth muscle and affects myocardial contractility and heart rate through the sympathetic nervous system.Serpin A8/Angiotensinogen Protein, Rat (HEK293, His) is the recombinant rat-derived Serpin A8/Angiotensinogen protein, expressed by HEK293 , with C-His labeled tag.

HY-P73652

	Serpin A8/Angiotensinogen Protein, Mouse (HEK293, His) Angiotensinogen; Serpin A8; AGT; SERPINA8	Mouse	HEK293
	Serpin A8 (or angiotensinogen) is an important regulator in the renin-angiotensin system, fine-tuning blood pressure and electrolyte balance. This multifunctional protein acts as a potent vasoconstrictor, affecting vascular smooth muscle and affecting cardiac function via the sympathetic nervous system. Serpin A8/Angiotensinogen Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A8/Angiotensinogen protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A8/Angiotensinogen Protein, Mouse (HEK293, His) is 453 a.a., with molecular weight of ~58 kDa.

HY-P73653

	Serpin A8/Angiotensinogen Protein, Human (HEK293, His) Angiotensinogen; Serpin A8; AGT; SERPINA8	Human	HEK293
	Serpin A8/angiotensinogen protein is an important component of the renin-angiotensin system (RAS), which regulates blood pressure, fluid balance, and electrolyte homeostasis. Serpin A8/Angiotensinogen Protein, Human (HEK293, His) is the recombinant human-derived Serpin A8/Angiotensinogen protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A8/Angiotensinogen Protein, Human (HEK293, His) is 452 a.a., with molecular weight of 52-64 kDa.

HY-P72477

	Serpin A8/Angiotensinogen Protein, Human (HEK293, His, solution) Angiotensinogen; Serpin A8; AGT and SERPINA8	Human	HEK293
	Serpin A8/angiotensinogen protein is an important component of the renin-angiotensin system (RAS), which regulates blood pressure, fluid balance, and electrolyte homeostasis. Serpin A8/Angiotensinogen Protein, Human (HEK293, His, solution) is the recombinant human-derived Serpin A8/Angiotensinogen protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin A8/Angiotensinogen Protein, Human (HEK293, His, solution) is 452 a.a., with molecular weight of 55.0-72.27 kDa.

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HY-P82352

	Angiotensinogen Antibody (YA2097) Angiotensinogen; Serpin A8; AGT; SERPINA8; Des-Asp[1]-angiotensin II; Serine (or cysteine) proteinase inhibitor	WB, IHC-P, IP	Mouse
	Angiotensinogen Antibody (YA2097) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2097), targeting Angiotensinogen, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). Angiotensinogen Antibody (YA2097) can be used for WB, IHC-P, IP experiment in mouse background.

HY-P82275

	AGXT Antibody (YA2020) AGT; PH1; SPT; AGT1; SPAT; TLH6; AGXT1	WB	Mouse, Rat
	AGXT Antibody (YA2020) is a non-conjugated IgG antibody, targeting AGXT, with a predicted molecular weight of 43 kDa (observed band size: 43 kDa). AGXT Antibody (YA2020) can be used for WB experiment in mouse, rat background.

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Cat. No.	Product Name		Classification

HY-148413

Aprinocarsen sodium 1 Publications Verification ISIS 3521 sodium		Antisense Oligonucleotides
Aprinocarsen (ISIS 3521) sodium, a specific antisense oligonucleotide inhibitor of protein kinase C-alpha (PKC-α). Aprinocarsen sodium is a 20-mer oligonucleotide, it regulates cell differentiation and proliferation. Aprinocarsen sodium inhibits the growth of human tumor cell lines in nude mice. Aprinocarsen sodium shows the value as a chemotherapeutic compound of human cancers .

HY-108764

Mipomersen sodium ISIS 301012		Antisense Oligonucleotides
Mipomersen sodium (ISIS 301012) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen sodium can be used for the research of homozygous familial hypercholesterolemia (HoFH) .

HY-RS00466

AGT Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
AGT Human Pre-designed siRNA Set A contains three designed siRNAs for AGT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-150740

ODN 21595		CpG ODNs
ODN 21595 is a Guanine-Modified TLR7 and TLR9 inhibitor. ODN 21595 inhibits the release of IFN-α and IL-6 with no cytotoxic. ODN 21595 reduces the expression of CD86 and HLA-DR. ODN 21595 has the potential for the research of systemic lupus erythematosus (SLE) .

HY-150738

ODN 2088		CpG ODNs
ODN 2088 is a potent TLR3, TLR7 and TLR9 inhibitor. ODN 2088 shows no cytotoxic. ODN 2088 inhibits the release of IFN-α and IL-6 .

HY-150736

ODN 20844		CpG ODNs
ODN 20844, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a TLR7 and TLR9 (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 20844 disrupts TLR7- and TLR9-mediated immune cell immune responses. ODN 20844 sequence: 5'-TCCTGGCGc7GGGAAGT-3' .

HY-150744

ODN 24888		CpG ODNs
ODN 24888 is an guanine-modified inhibitory oligonucleotides (INH-ODN), shows potent inhibition on TLR7/TLR9-mediated signaling. ODN 24888 impairs IFN-α level and NF-κB activation, inhibits IL-6 release. ODN 24888 involves in immune and inflammatory responses, can be used as a vaccine adjuvant .

HY-150215

ODN 105870		CpG ODNs
ODN 105870, a G-modified inhibitory oligonucleotide (INH-ODN), is a selective TLR7 inhibitor. ODN 105870 can be uesd for inflammatory immune responses research .

HY-150216

ODN 105871		CpG ODNs
ODN 105871, a G-modified inhibitory oligonucleotide (INH-ODN), is a selective TLR7 inhibitor. ODN 105871 can be uesd for inflammatory immune responses research .

HY-143230

Custirsen OGX-011		Antisense Oligonucleotides
Custirsen is a highly specific antisense oligonucleotide that inhibits the production of clusterin , an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance.

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