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APA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Aminopeptidase (3) Bacterial (3) COX (1) Cytochrome P450 (1) Drug Metabolite (1) Endogenous Metabolite (1) HSP (1) Leukotriene Receptor (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Infection (4) Inflammation/Immunology (1)

12

Inhibitors & Agonists

1

Natural
Products

3

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

6-Aminopenicillanic acid 6-APA	Bacterial	Infection
6-Aminopenicillanic acid (6-APA) is an important precursor for the synthesis of -lactam antibiotics. 6-Aminopenicillanic acid is the main product of Penicillin G (PenG) hydrolyzed by penicillin acylase (PA) .

S186	Others	Others
S186 is a kind of sodium salts of calcium-acetylpropylamine phosphonate(APA); a new strontium-specific chelating agent.

Revaprazan hydrochloride 1 Publications Verification	Bacterial COX	Infection
Revaprazan hydrochloride is a novel acid pump antagonist (APA). Revaprazan hydrochloride reduces COX-2 expression and has significant anti-inflammatory actions activities in H. pylori infection .

NAT2-IN-1 APA	Others	Cancer
NAT2-IN-1 (APA) is an inhibitor of agent metabolic enzyme N-acetyltransferase 2 (NAT2). NAT2-IN-1 can selectively kill slow NAT2 cells .

*17-GMB-APA-GA*	ADC Cytotoxin HSP	Infection Cancer
17-GMB-APA-GA is an ADC Cytotoxin. 17-GMB-APA-GA is a potent HSP90 inhibitor and used for latent T. gondii infection research .

Leukotriene B4-3-aminopropylamide LTB4-APA	Leukotriene Receptor	Inflammation/Immunology
Leukotriene B4-3-aminopropylamide (LTB4-APA) is a leukotriene immunomodulator .

HY-W013549R

6-Aminopenicillanic acid (Standard)	Drug Metabolite Bacterial	Infection
6-Aminopenicillanic acid (Standard) is the analytical standard of 6-Aminopenicillanic acid. This product is intended for research and analytical applications. 6-Aminopenicillanic acid (6-APA) is an important precursor for the synthesis of ?-lactam antibiotics. 6-Aminopenicillanic acid is the main product of Penicillin G (PenG) hydrolyzed by penicillin acylase (PA) .

Amastatin	Aminopeptidase	Others
Amastatin is A slow, tightly bound, competitive inhibitor of aminopeptidase (AP) with an IC₅₀ of 0.54 μg/mL for AP-A .

AMK-GX Immobilized Penicillin G acylase	Endogenous Metabolite	Others
AMK-GX (Immobilized Penicillin G acylase) is an immobilized penicillin acylase with improved temperature and pH stability. AMK-GX has reusable performance and high recovery rates, retaining much of its original activity after 12 cycles. Among them, AMK-GX can catalyze penicillin G (PG) to generate 6-aminopenicillanic acid (6-APA) and 7-aminodeacetoxycephalosporanic acid, which are key intermediates for β-lactam antibiotics .

CYP11B2-IN-2	Cytochrome P450	Cancer
CYP11B2-IN-2 (Compound 10k) is an inhibitor for enzyme aldosterone synthase CYP11B2 with an IC₅₀ of 0.3 nM. CYP11B2-IN-2 CYP11B-IN-2 is labeled with 18F and can be used as a positron emission tomography (PET) tracer for the diagnosis of primary aldosteronism .

EC33	Aminopeptidase	Cardiovascular Disease
EC33 is a selective aminopeptidase A (APA) inhibitor. EC33 blocks the pressor response of exogenous Ang II. EC33 does not cross the blood-brain barrier. EC33 has the potential for salt-dependent model of hypertension research .

Firibastat 1 Publications Verification QGC001; RB150	Aminopeptidase	Cardiovascular Disease
Firibastat (QGC001), an orally active brain penetrating proagent of EC33, is a first-in-class brain aminopeptidase A (APA) inhibitor (K_i=200 nM). Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats .

Species:	Human (1) Mouse (1) Rat (1)
Tag:	His (3)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source

	Aminopeptidase A Protein, Mouse (sf9, His) Glutamyl aminopeptidase; EAP; AP-A; CD249; ENPEP	Mouse	Sf9 insect cells
	The aminopeptidase A protein is a key player in the regulation of central hypertension, exerting its effects by selectively cleaving the N-terminal acidic residues of peptides such as angiotensin II. The enzyme's preference for specific substrates is regulated by calcium levels, underscoring its critical role in controlling blood pressure and maintaining cardiovascular health. Aminopeptidase A Protein, Mouse (sf9, His) is the recombinant mouse-derived Aminopeptidase A protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Aminopeptidase A Protein, Mouse (sf9, His) is 905 a.a., with molecular weight of ~113 kDa.

	Aminopeptidase A Protein, Human (sf9, His) Glutamyl aminopeptidase; EAP; AP-A; CD249; ENPEP	Human	Sf9 insect cells
	Aminopeptidase A protein has calcium-regulating activity and plays a key role in central hypertension by preferentially cleaving N-terminal acidic residues, including angiotensin II. The specificity of this enzyme highlights its involvement in the regulation of blood pressure-related peptides, suggesting potential implications for the physiological mechanisms of hypertension. Aminopeptidase A Protein, Human (sf9, His) is the recombinant human-derived Aminopeptidase A protein, expressed by Sf9 insect cells , with N-His labeled tag.

	Aminopeptidase A Protein, Rat (sf9, His) Glutamyl aminopeptidase; EAP; AP-A; CD249; ENPEP	Rat	Sf9 insect cells
	Aminopeptidase A, modulated by calcium, regulates central hypertension by preferentially cleaving N-terminal acidic residues from peptides, including angiotensin II. Aminopeptidase A Protein, Rat (sf9, His) is the recombinant rat-derived Aminopeptidase A protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Aminopeptidase A Protein, Rat (sf9, His) is 905 a.a., with molecular weight of ~116 kDa.

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	AP-A Antibody (YA2164) AP-A; Aminopeptidase A; APA; bp1; CD249; EAP; Enpep; Gp160; Ly51	WB, IHC-P	Human
	AP-A Antibody (YA2164) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2164), targeting AP-A, with a predicted molecular weight of 109 kDa (observed band size: 160 kDa). AP-A Antibody (YA2164) can be used for WB, IHC-P experiment in human background.

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