2. Metabolic Enzyme/Protease Anti-infection
  3. Drug Metabolite Bacterial
  4. 6-Aminopenicillanic acid

6-Aminopenicillanic acid  (Synonyms: 6-APA)

Cat. No.: HY-W013549 Purity: ≥98.0%
Data Sheet
SDS
COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

6-Aminopenicillanic acid (6-APA) is a parent amine, an important precursor for the synthesis of β-lactam antibiotics and an antibacterial agent. 6-Aminopenicillanic acid interferes with cell wall synthesis during bacterial division in a manner similar to penicillin. 6-Aminopenicillanic acid has antibacterial activity against Gram-negative bacteria. 6-Aminopenicillanic acid is mainly used in the study of Penicillin-associated immune responses.

For research use only. We do not sell to patients.

6-Aminopenicillanic acid Chemical Structure

6-Aminopenicillanic acid Chemical Structure

CAS No. : 551-16-6

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Based on 1 publication(s) in Google Scholar

Other Forms of 6-Aminopenicillanic acid:

6-Aminopenicillanic acid Related Antibodies

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Description

6-Aminopenicillanic acid (6-APA) is a parent amine, an important precursor for the synthesis of β-lactam antibiotics and an antibacterial agent. 6-Aminopenicillanic acid interferes with cell wall synthesis during bacterial division in a manner similar to penicillin. 6-Aminopenicillanic acid has antibacterial activity against Gram-negative bacteria. 6-Aminopenicillanic acid is mainly used in the study of Penicillin-associated immune responses[1][2][3][4].

In Vitro

6-Aminopenicillanic acid (Sodium 6-aminopenicillanate, 0.34-3.4 μmol/mL, 4-5 h) can induce spheroplast formation in Gram-negative bacteria[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6-Aminopenicillanic acid Related Antibodies
In Vivo

6-Aminopenicillanic acid (injected with penicillin emulsified in complete Freund's adjuvant; intradermal and s.c. injection; multiple times) induces a more potent antibody response in rabbits compared to Penicillins G (HY-N7139), 0, or V (HY-B0975A)[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

216.26

Formula

C8H12N2O3S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

[C@H]12SC([C@@H](N1C(=O)[C@H]2N)C(=O)O)(C)C
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

0.1 M HCL : 12.5 mg/mL (57.80 mM; ultrasonic and adjust pH to 2 with HCl)

0.1 M NaOH : 5 mg/mL (23.12 mM; Need ultrasonic)

H2O : 0.33 mg/mL (1.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6240 mL 23.1201 mL 46.2402 mL
5 mM 0.9248 mL 4.6240 mL 9.2480 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation

Purity: ≥98.0%

Data Sheet (278 KB) SDS (393 KB)

COA (256 KB) HNMR (280 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / 0.1 M NaOH / 0.1 M HCL 1 mM 4.6240 mL 23.1201 mL 46.2402 mL 115.6005 mL
0.1 M NaOH / 0.1 M HCL 5 mM 0.9248 mL 4.6240 mL 9.2480 mL 23.1201 mL
10 mM 0.4624 mL 2.3120 mL 4.6240 mL 11.5601 mL
15 mM 0.3083 mL 1.5413 mL 3.0827 mL 7.7067 mL
20 mM 0.2312 mL 1.1560 mL 2.3120 mL 5.7800 mL
0.1 M HCL 25 mM 0.1850 mL 0.9248 mL 1.8496 mL 4.6240 mL
30 mM 0.1541 mL 0.7707 mL 1.5413 mL 3.8534 mL
40 mM 0.1156 mL 0.5780 mL 1.1560 mL 2.8900 mL
50 mM 0.0925 mL 0.4624 mL 0.9248 mL 2.3120 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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6-Aminopenicillanic acid Related Classifications

Keywords:

6-Aminopenicillanic acid551-16-66-APADrug MetaboliteBacterialβ-lactamantibioticsPenicillinGPenGacylasePAInhibitorinhibitorinhibit

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