ASIC-3

By Targets:	Neuropeptide Y Receptor (2) Small Interfering RNA (siRNA) (2) Sodium Channel (8)
By Research Areas:	Cancer (1) Inflammation/Immunology (2) Neurological Disease (10)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122135

A-317567	Sodium Channel	Neurological Disease
A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC₅₀ of 1.025 μM. A-317567 has antidepressant and antinociception effects .

HY-100939

4-Chlorophenylguanidine hydrochloride	Sodium Channel	Neurological Disease
4-Chlorophenylguanidine hydrochloride is a potent *ASIC3* positive allosteric modulator and reverses the effects of ASIC3 desensitization. 4-Chlorophenylguanidine hydrochloride influences ASIC3 activity through directly activating the channel and increasing proton sensitivity. 4-Chlorophenylguanidine hydrochloride offers a chemical backbone for the design of new ASIC3 ligands to study ASIC3 in vivo .

HY-107757

GMQ	Sodium Channel	Neurological Disease
GMQ is a *ASIC* (acid-sensing ion) channel activator with an EC₅₀ value of 1.83 mM for ASIC3 at pH 7.4. GMQ opens only ASIC3 but no other ASICs at pH 7.4. GMQ can be used for neurological disease research .

HY-P1346A

APETx2 TFA	Sodium Channel	Neurological Disease Inflammation/Immunology
APETx2 TFA, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible *ASIC3* inhibitor, with an IC₅₀ of 63 nM. APETx2 directly inhibits the ASIC3 channel by acting at its external side. APETx2 could reverses acid‐induced and inflammatory pain .

HY-RS01091

ASIC3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ASIC3 Human Pre-designed siRNA Set A contains three designed siRNAs for ASIC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ASIC3 Human Pre-designed siRNA Set A ASIC3 Human Pre-designed siRNA Set A

HY-RS17225

Asic3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
Asic3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Asic3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Asic3 Mouse Pre-designed siRNA Set A Asic3 Mouse Pre-designed siRNA Set A

HY-P1346

APETx2	Sodium Channel	Neurological Disease Inflammation/Immunology
APETx2, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible *ASIC3* inhibitor, with an IC₅₀ of 63 nM. APETx2 directly inhibits the ASIC3 channel by acting at its external side. APETx2 could reverses acid‐induced and inflammatory pain .

HY-155017

6-Iodoamiloride	Sodium Channel	Neurological Disease Cancer
6-Iodoamiloride is a potent acid-sensing ion channel 1 (ASIC1) inhibitor with an IC₅₀ of 88 nM. 6-Iodoamiloride inhibits ASIC3-mediated currents from rat dorsal root ganglion neurons with an IC₅₀ of 230 nM .

HY-P1249

Neuropeptide SF(mouse,rat)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide SF (mouse,rat) is a potent neuropeptide FF receptor agonist with K_i values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) .

HY-P1249A

Neuropeptide SF(mouse,rat) TFA	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide SF (mouse,rat) TFA is a potent neuropeptide FF receptor agonist with K_i values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF TFA increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) .

HY-131879

NS383	Sodium Channel	Neurological Disease
NS383 is a potent and uniquely selective inhibitor of rat *ASICs* containing 1a and/or 3 subunits. NS383 inhibits H(+)-activated currents recorded from rat homomeric ASIC1a, ASIC3, and heteromeric ASIC1a+3 with IC₅₀ values ranging from 0.61 to 2.2 μM. NS383 is well tolerated and capable of reversing pathological painlike behaviors, presumably via peripheral actions, but possibly also via actions within central pain circuits .

HY-P1441A

Mambalgin 1 TFA	Sodium Channel	Neurological Disease
Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC₅₀ values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.

Cat. No.	Product Name	Target	Research Area

HY-P1346A

APETx2 TFA	Sodium Channel	Neurological Disease Inflammation/Immunology
APETx2 TFA, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible *ASIC3* inhibitor, with an IC₅₀ of 63 nM. APETx2 directly inhibits the ASIC3 channel by acting at its external side. APETx2 could reverses acid‐induced and inflammatory pain .

HY-P1441A

Mambalgin 1 TFA	Sodium Channel	Neurological Disease
Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC₅₀ values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.

HY-P1346

APETx2	Sodium Channel	Neurological Disease Inflammation/Immunology
APETx2, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible *ASIC3* inhibitor, with an IC₅₀ of 63 nM. APETx2 directly inhibits the ASIC3 channel by acting at its external side. APETx2 could reverses acid‐induced and inflammatory pain .

HY-P1249

Neuropeptide SF(mouse,rat)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide SF (mouse,rat) is a potent neuropeptide FF receptor agonist with K_i values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) .

HY-P1249A

Neuropeptide SF(mouse,rat) TFA	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide SF (mouse,rat) TFA is a potent neuropeptide FF receptor agonist with K_i values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF TFA increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P1346

APETx2	Structural Classification Natural Products Animals Source classification	Sodium Channel
APETx2, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible *ASIC3* inhibitor, with an IC₅₀ of 63 nM. APETx2 directly inhibits the ASIC3 channel by acting at its external side. APETx2 could reverses acid‐induced and inflammatory pain .

Cat. No.	Product Name		Classification

HY-RS01091

ASIC3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ASIC3 Human Pre-designed siRNA Set A contains three designed siRNAs for ASIC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17225

Asic3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Asic3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Asic3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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ASIC-3

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