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Pathways Recommended: Antibody-drug Conjugate/ADC Related
Results for "

Antimalarial drugs

" in MedChemExpress (MCE) Product Catalog:

17

Inhibitors & Agonists

1

Natural
Products

1

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0803
    Lumefantrine
    1 Publications Verification

    Benflumetol

    		 Parasite Infection
    Lumefantrine is an active antimalarial molecule used in combination with Artemether as a first- and second-line antimalarial drug with oral activity .
    Lumefantrine
  • HY-B0803S1
    Lumefantrine-d9

    Benflumetol-d9

    		 Isotope-Labeled Compounds Parasite Autophagy Infection
    Lumefantrine-d9 is the deuterium labeled Lumefantrine. Lumefantrine is an antimalarial drug, used in combination with Artemether. The artemether-lumefantrine (AL) as the first- and second-line anti-malarial drugs.
    Lumefantrine-d9
  • HY-N0402
    Artemether
    1 Publications Verification

    Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224

    		 Parasite Infection Inflammation/Immunology Cancer
    Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria .
    Artemether
  • HY-100358
    AQ-13 dihydrochloride

    		Parasite Infection
    AQ-13 dihydrochloride is an aminoquinoline antimalarial agent that is effective against drug-resistant strains of Plasmodium falciparum.
    AQ-13 dihydrochloride
  • HY-111746
    CWHM-1008
    1 Publications Verification

    		 Parasite Infection
    CWHM-1008 is a potent and orally active antimalarial agent, with EC50 values of 46 and 21 nM against agent-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains, respectively .
    CWHM-1008
  • HY-108024A
    Ganaplacide hydrochloride

    KAF156 hydrochloride; GNF156 hydrochloride

    		 Parasite Infection
    Ganaplacide (KAF156) hydrochloride is a first-in-class, orally active imidazolopiperazine antimalarial agent. Ganaplacide hydrochloride is active against a broad range of Plasmodium species, including drug-resistant parasites. Ganaplacide hydrochloride is parasiticidal against both asexual and sexual blood stages as well as the liver stages of the parasite .
    Ganaplacide hydrochloride
  • HY-122274
    MMV666693

    		Parasite Infection
    MMV666693 is a translation inhibitor specific for Plasmodium falciparum. MMV666693 has low cytotoxicity in human fibroblasts (IC50>32 µM) and can be used in the development of antimalarial drugs .
    MMV666693
  • HY-W738358
    Chlorproguanil hydrochloride

    		Parasite Infection
    Chlorproguanil (hydrochloride) is an antimalarial drug. Chlorproguanil (hydrochloride) is a dichloro-derivative of chloroguanide .
    Chlorproguanil hydrochloride
  • HY-B0803R
    Lumefantrine (Standard)

    		Parasite Autophagy Infection
    Lumefantrine (Standard) is the analytical standard of Lumefantrine. This product is intended for research and analytical applications. Lumefantrine is an active antimalarial molecule used in combination with Artemether as a first- and second-line antimalarial drug.
    Lumefantrine (Standard)
  • HY-12651B
    l-Primaquine

    		Others Infection
    l-Primaquine is an antimalarial drug with activity in inhibiting and preventing malaria. l-Primaquine is also used to inhibit Pneumocystis jiroveci pneumonia .
    l-Primaquine
  • HY-108024
    Ganaplacide

    KAF156; GNF156

    		 Parasite Infection
    Ganaplacide (KAF156) is a first-in-class, orally active imidazolopiperazine antimalarial agent. Ganaplacide is active against a broad range of Plasmodium species, including drug-resistant parasites. Ganaplacide is parasiticidal against both asexual and sexual blood stages as well as the liver stages of the parasite .
    Ganaplacide
  • HY-124112
    PAM 1392

    		Parasite Infection
    PAM 1392 is active orally against Plasmodium berghei in mice, P. cynofologi and P. knowlesi in monkeys and Trypanosoma cruzi in tissue cultures of mice, and hemolytic streptococci in vitro. PAM 1392 has antimalarial and antitrypanosomal activities, which is proming for rasearch of drug-resistant malaria .
    PAM 1392
  • HY-161799
    LysRs-IN-3

    		Aminoacyl-tRNA Synthetase Parasite Infection
    LysRs-IN-3 (compound 36) is an inhibitor of Plasmodium lysine tRNA synthetase based on ASP3026 (HY-13326), which has a more than seven-fold higher inhibitory effect on the growth of Plasmodium, especially Plasmodium falciparum, than ASP3026 (HY-13326). LysRs-IN-3 can be used in the development of antimalarial drugs .
    LysRs-IN-3
  • HY-161800
    Aminoacyl tRNA synthetase-IN-3

    		Aminoacyl-tRNA Synthetase Infection
    Aminoacyl tRNA synthetase-IN-3 (compound 36K3) is an inhibitor of lysine tRNA synthetase (PfLysRS) from Plasmodium falciparum (IC50=59.2 nM), which inhibits the activity of PfLysRS by occupying the ATP binding site and L-lysine binding site of PfLysRS. Aminoacyl tRNA synthetase-IN-3 can be used in the development of antimalarial drugs .
    Aminoacyl tRNA synthetase-IN-3
  • HY-19877
    GSK932121

    		Others Infection
    GSK932121 is an antimalarial drug with activity that inhibits the electron transport chain of P. falciparum. GSK932121 acts selectively on this pathogen at the level of cytochrome bc1 (complex III). The synthesis method of GSK932121 is highly efficient, and the final structure can be obtained in only 5 steps. The synthesis of GSK932121 can be prepared atKilog scale to support clinical studies .
    GSK932121
  • HY-W031727
    Hydroxychloroquine
    Maximum Cited Publications
    55 Publications Verification

    		 Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy Infection Cancer
    Hydroxychloroquine (HCQ) is a synthetic oral antimalarial drug that can be used in the study of malaria and autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. Hydroxychloroquine is a potent autophagic flux inhibitor with antiviral activity (such as SARS-CoV-2 virus) that inhibits Toll-like receptor 7/9 (TLR7/9) signaling .
    Hydroxychloroquine
  • HY-161984
    HDAC-IN-76

    		HDAC Infection Others
    HDAC-IN-76 (compound 6i) is a histone deacetylase (HDAC) inhibitor. HDAC-IN-76 IC50 values of 30 nM and 98 nM for Pf3D7 (chloroquine (HY-17589A) drug-susceptible strain) and PfDd2 (chloroquine (HY-17589A) drug-resistant strain), has a highly potent antimalarial activity against asexual blood-stage Plasmodium, respectively, and exhibits selective inhibition against parasites, with IC50 values of 7 nM and 9 nM for human HDAC1 and HDAC6, respectively, while inhibiting PfHDAC1 .
    HDAC-IN-76

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