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Isoforms Recommended:	BACE2

Results for "

BACE2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Beta-secretase (16) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (14)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136742

BACE2-IN-1	Beta-secretase	Metabolic Disease
BACE2-IN-1 (compound 3l) is a highly selective *BACE2* inhibitor with a K ⁱ value of 1.6 nM. BACE2 inhibitors can be used to research of Type 2 Diabetes .

HY-16759

Verubecestat 3 Publications Verification MK-8931	Beta-secretase	Neurological Disease
Verubecestat (MK-8931) is an orally active, high-affinity *BACE1* and *BACE2* inhibitor with K_i values of 2.2 nM and 0.38 nM. Verubecestat effectively reduces Aβ40 and has the potential for Alzheimer's Disease ^[2].

HY-13240

LY2886721 2 Publications Verification	Beta-secretase	Neurological Disease
LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC₅₀ of 20.3 nM for recombinant human *BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2* (IC₅₀ of 10.2 nM). LY2886721 can across blood-brain barrier and has the potential for Alzheimer's disease treatment .

HY-RS01336

BACE2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BACE2 Human Pre-designed siRNA Set A contains three designed siRNAs for BACE2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BACE2 Human Pre-designed siRNA Set A BACE2 Human Pre-designed siRNA Set A

HY-RS01337

Bace2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bace2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bace2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bace2 Mouse Pre-designed siRNA Set A Bace2 Mouse Pre-designed siRNA Set A

HY-RS01338

Bace2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Bace2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bace2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bace2 Rat Pre-designed siRNA Set A Bace2 Rat Pre-designed siRNA Set A

HY-16759B

Verubecestat tosylate MK-8931 tosylate	Beta-secretase	Neurological Disease
Verubecestat tosylate is an orally active, high-affinity *BACE1* and *BACE2* inhibitor with K_i values of 2.2 nM and 0.38 nM. Verubecestat tosylate effectively reduces Aβ40 and has the potential for Alzheimer's Disease ^[2].

HY-16759A

Verubecestat TFA MK-8931 TFA	Beta-secretase	Neurological Disease
Verubecestat (MK-8931) TFA is an orally active, high-affinity *BACE1* and *BACE2* inhibitor with K_i values of 2.2 nM and 0.38 nM. Verubecestat TFA effectively reduces Aβ40 and has the potential for Alzheimer's Disease ^[2].

HY-118098

LY3202626	Beta-secretase	Neurological Disease
LY3202626 is a CNS penetrant *BACE* inhibitor with IC₅₀s of 0.615 nM and 0.871 nM against BACE1 and BACE2, respectively .

HY-13240A

LY2886721 hydrochloride	Beta-secretase	Neurological Disease
LY2886721 hydrochloride is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC₅₀ of 20.3 nM for recombinant human *BACE1. LY2886721 hydrochloride is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2* (IC₅₀ of 10.2 nM). LY2886721 hydrochloride can across blood-brain barrier and has the potential for Alzheimer's disease treatment .

HY-100182

BACE1-IN-1	Beta-secretase	Neurological Disease
BACE1-IN-1 is a potent and highly brain penetrant *BACE1* inhibitor with IC₅₀s of 32 and 47 nM for human BACE1 and BACE2, respectively.

HY-124322

NB-360	Beta-secretase	Neurological Disease Inflammation/Immunology
NB-360 is a potent, brain penetrable, and orally bioavailable dual *BACE1/BACE2* inhibitor (IC₅₀: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E ^[2].

HY-128594

BACE1-IN-4	Beta-secretase	Neurological Disease
BACE1-IN-4 is a potent and highly selective *BACE1* inhibitor, with an IC₅₀ of 3.8 nM and a K_i of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer’s disease .

HY-12938

AMG-8718	Beta-secretase	Neurological Disease
AMG-8718 is a potent, selective and orally active *BACE1* inhibitor with IC₅₀ values of 0.0007, 0.005 µM for BACE1 and BACE2, respectively. AMG-8718 significantly decreases Aβ₄₀ levels in the CSF and brain .

HY-161359

BACE1-IN-14	Beta-secretase	Neurological Disease
BACE1-IN-14 (compound 27f) is a *BACE1* inhibitor, with the EC₅₀ values of 0.7 μM and 1.6 μM for *BACE1* and *BACE2. BACE*1-IN-14 is can be used in Alzheimer's disease (AD) research .

HY-147758

BACE1/2-IN-1	Beta-secretase Amyloid-β	Neurological Disease
BACE1/2-IN-1 (compound 34) is a potent *BACE1* and *BACE2* inhibitor, with an IC₅₀ of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 shows a combination of lower Pgp efflux ratio and improved passive permeability. BACE1/2-IN-1 displays reduced liver microsomal metabolic stability .

HY-10472

LY2811376 Maximum Cited Publications 11 Publications Verification	Beta-secretase	Neurological Disease
LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC₅₀ of 239 nM-249 nM, that acts to decrease Aβ secretion with EC₅₀ of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.

HY-128774

AM-6494	Beta-secretase	Neurological Disease
AM-6494 is a potent and orally active *BACE1* (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC₅₀=0.4 nM) with in vivo selectivity over BACE2 (IC₅₀=18.6 nM) . AM-6494 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-13438

AZD3839 free base 1 Publications Verification	Beta-secretase	Cancer
AZD3839 free base is a potent and selective orally active, brain-permeable *BACE1* inhibitor (K_i=26 nM). AZD3839 free base shows 14 and >1000-fold selectivity against BACE2 and cathepsin D, respectively. AZD3839 free base exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate. AZD3839 free base can be used for the research of Alzheimer's disease ^[2].

Cat. No.	Compare	Product Name	Species	Source

HY-P75588

	BACE2 Protein, Mouse (HEK293, His) Beta-secretase 2; Aspartyl protease 1; ASP1; Memapsin-1; BACE2	Mouse	HEK293
	The BACE2 protein is critically involved in the proteolytic processing of amyloid precursor protein (APP), producing beta-cleaved soluble APP and a cell-associated C-terminal fragment. It cleaves APP at residues 690-691 and 671-672. BACE2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived BACE2 protein, expressed by HEK293 , with C-His labeled tag. The total length of BACE2 Protein, Mouse (HEK293, His) is 443 a.a., with molecular weight of ~55 kDa.

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Cat. No.	Product Name		Classification

HY-128774

AM-6494		Alkynes
AM-6494 is a potent and orally active *BACE1* (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC₅₀=0.4 nM) with in vivo selectivity over BACE2 (IC₅₀=18.6 nM) . AM-6494 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

BACE2 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
BACE2 Human Pre-designed siRNA Set A contains three designed siRNAs for BACE2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bace2 Mouse Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Bace2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bace2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bace2 Rat Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
Bace2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bace2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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