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Results for "

BTK-IN-15

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

1

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100659
    Dihydrodiol-Ibrutinib

    PCI-45227

    		 Btk Cancer
    Dihydrodiol-Ibrutinib (PCI-45227) is a dihydrodiol active metabolite of Ibrutinib (HY-10997), has inhibitory activity towards BTK approximately 15 times lower than that of ibrutinib .
    Dihydrodiol-Ibrutinib
  • HY-150752
    BTK-IN-15

    		Btk Pyroptosis Cancer
    BTK-IN-15 (compound 42) is a potent Bruton's tyrosine kinase (BTK) inhibitor with high oral absorption. BTK-IN-15 inhibits BTK with an IC50 value of 0.7 nM. BTK-IN-15 displays excellent kinase selectivity, antitumor activity, and induces apoptosis .
    BTK-IN-15
  • HY-168965
    BTK ligand 15

    		Ligands for Target Protein for PROTAC Others
    BTK ligand 15 is the target protein ligand of PROTAC BTK Degrader-13 (HY-168963). PROTAC BTK Degrader-13 can selectively degrade BTK .
    BTK ligand 15
  • HY-100659S
    Dihydrodiol-Ibrutinib-d5

    PCI-45227-d5

    		 Btk Isotope-Labeled Compounds Cancer
    Dihydrodiol-Ibrutinib-d5 is the deuterium labeled Dihydrodiol-Ibrutinib (HY-100659). Dihydrodiol-Ibrutinib is a dihydrodiol active metabolite of Ibrutinib (HY-10997), has inhibitory activity towards BTK approximately 15 times lower than that of ibrutinib .
    Dihydrodiol-Ibrutinib-d5
  • HY-168963
    PROTAC BTK Degrader-13

    		PROTACs Btk Itk p38 MAPK Inflammation/Immunology Cancer
    PROTAC BTK Degrader-13 (Compound 25) is the PROTAC degrader for BTK with a DC50 of 0.27 μM. PROTAC BTK Degrader-13 inhibits the activity of BTK with an IC50 of 0.44 μM, inhibits IL-2-induced T cell kinase (ITK) with an IC50 of 2.16 μM. PROTAC BTK Degrader-13 inhibits p38 MAPK signaling pathway, block the activation of the BCR (B cell receptor) signaling pathway . (Pink: ligand for target protein BTK ligand 15 (HY-168965); Black: linker (HY-Y0524); Blue: ligand for E3 ligase cereblon (HY-103596))
    PROTAC BTK Degrader-13

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