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Results for "

CARM1

" in MedChemExpress (MCE) Product Catalog:

29

Inhibitors & Agonists

1

Recombinant Proteins

1

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-156152A
    CARM1 degrader-1 hydrochloride

    		Histone Methyltransferase PROTACs Cancer
    CARM1 degrader-1 hydrochloride is the hydrochloride salt form of CARM1 degrader-1 (HY-156152). CARM1 degrader-1 hydrochloride is a PROTAC degrader for co-activator associated argininemethyltransferase 1 (CARM1), which degrades CARM1 in a VHL- and proteasome-dependent manner with a DC50 of 8.1 nM. CARM1 degrader-1 hydrochloride inhibits methylation of CARM1 substrates such as poly(A)-binding protein PABP1 and BGR1-associated factor BAF155, and thus inhibits breast cancer cell migration [1].
    CARM1 degrader-1 hydrochloride
  • HY-157388
    CARM1/HDAC2-IN-1

    		Histone Methyltransferase HDAC Cancer
    CARM1/HDAC2-IN-1 (compound CH-1) is a dual inhibitor against CARM1 and HDAC2, with IC50 values of 3.71 nM and 4.07 nM, respectively. CARM1/HDAC2-IN-1 possesses antitumor activity [1].
    CARM1/HDAC2-IN-1
  • HY-156153
    CARM1 degrader-2

    		Histone Methyltransferase Cancer
    PROTAC CARM1 degrader-2 (compound 3e) is a degrader (DC50=8.8 nM) of co-activator associated argininemethyltransferase (CARM1). PROTAC CARM1 degrader-2 degrades CARM1 in a VHL- and proteasome-dependent manner. Thus, PROTAC CARM1 degrader-2 inhibits methylation of CARM1 substrates such as poly(A)-binding protein PABP1 and BGR1-associated factor BAF155 and inhibits breast cancer cell migration [1].
    CARM1 degrader-2
  • HY-156152
    CARM1 degrader-1

    		Histone Methyltransferase Cancer
    PROTAC CARM1 degrader-1 (compound 3b) is a degrader (DC50=8.1 nM) of co-activator associated argininemethyltransferase (CARM1). PROTAC CARM1 degrader-1 degrades CARM1 in a VHL- and proteasome-dependent manner. Thus, PROTAC CARM1 degrader-1 inhibits methylation of CARM1 substrates such as poly(A)-binding protein PABP1 and BGR1-associated factor BAF155 and inhibits breast cancer cell migration [1].
    CARM1 degrader-1
  • HY-RS01927
    Carm1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Carm1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Carm1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Carm1 Mouse Pre-designed siRNA Set A
    Carm1 Mouse Pre-designed siRNA Set A
  • HY-RS01926
    CARM1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CARM1 Human Pre-designed siRNA Set A contains three designed siRNAs for CARM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CARM1 Human Pre-designed siRNA Set A
    CARM1 Human Pre-designed siRNA Set A
  • HY-RS01928
    Carm1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Carm1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Carm1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Carm1 Rat Pre-designed siRNA Set A
    Carm1 Rat Pre-designed siRNA Set A
  • HY-161334
    CARM1-IN-4

    		Histone Methyltransferase Apoptosis Cancer
    CARM1-IN-4 (compound 11f) is a potent CARM1 inhibitor with IC50s of 9 nM and 56 nM for CARM1 and PRMT1, respectively. CARM1-IN-4 displays significant anti-proliferative effects on colorectal cancer cell lines. CARM1-IN-4 effectively inhibits the methyltransferase activity of CARM1 and prevents methylation of downstream proteins. CARM1-IN-4 induces apoptosis and shows antitumor activity [1].
    CARM1-IN-4
  • HY-158158
    CARM1-IN-5

    		Histone Methyltransferase Cancer
    CARM1-IN-5 (Compound 17e) is a potent and selective inhibitor of CARM1 (IC50= 2 nM). CARM1-IN-5 effectively prevents CARM1 from methylating substrate proteins by directly interacting with CARM1. CARM1-IN-5 exhibits significant antiproliferative effects on melanoma cell lines [1].
    CARM1-IN-5
  • HY-163561
    CARM1-IN-6

    		Histone Methyltransferase Cancer
    CARM1-IN-6 (iCARM1) is an effective and selective inhibitor of CARM1 with an IC50 value of 12.3 μM. CARM1-IN-6 exhibits cell growth inhibitory activity and can be used in cancer research [1].
    CARM1-IN-6
  • HY-15214
    CARM1-IN-3

    		Histone Methyltransferase Cancer
    CARM1-IN-3 (compound 17b) is a potent and selective co-activator associated arginine methyltransferase (CARM1) inhibitor with IC50 values of 0.07, >25 µM for CARM1 and CARM3, respectively [1].
    CARM1-IN-3
  • HY-15214A
    CARM1-IN-3 dihydrochloride

    		Histone Methyltransferase Cancer
    CARM1-IN-3 dihydrochloride (compound 17b) is a potent and selective co-activator associated arginine methyltransferase (CARM1) inhibitor with IC50 values of 0.07, >25 µM for CARM1 and CARM3, respectively [1].
    CARM1-IN-3 dihydrochloride
  • HY-172369
    CARM1/IKZF3 ligand 1

    		Histone Methyltransferase Ligands for Target Protein for PROTAC Cancer
    CARM1/IKZF3 ligand 1 is the inhibitor for CARM1 that can be used as the target protein ligand for synthesis of PROTAC CARM1/IKZF3 degrader-1 (HY-172368) [1].
    CARM1/IKZF3 ligand 1
  • HY-12759A
    CARM1-IN-1 hydrochloride
    3 Publications Verification

    		 Histone Methyltransferase Cancer
    CARM1-IN-1 hydrochloride is a potent and specific CARM1 (Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7.
    CARM1-IN-1 hydrochloride
  • HY-12759
    CARM1-IN-1
    3 Publications Verification

    		 Histone Methyltransferase Cancer
    CARM1-IN-1 is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM).
    CARM1-IN-1
  • HY-172368
    PROTAC CARM1/IKZF3 degrader-1

    		PROTACs Histone Methyltransferase IKZF Family Apoptosis Inflammation/Immunology Cancer
    PROTAC CARM1/IKZF3 degrader-1 (Compound 074) inhibits CARM1, reduces the methylation level of its substrate BAF155. PROTAC CARM1/IKZF3 degrader-1 is the PROTAC degrader for IKZF 1/3 through a CRBN-dependent pathway. PROTAC CARM1/IKZF3 degrader-1 inhibits the expression of MYC protein, thereby inhibiting the proliferation of a variety of multiple myeloma cells. PROTAC CARM1/IKZF3 degrader-1 induces apoptosis in cell H929. PROTAC CARM1/IKZF3 degrader-1 overcomes immunomodulatory drugs (IMiD, such as pomalidomide) resistance. PROTAC CARM1/IKZF3 degrader-1 can be used in cancer and immunology research [1]. (Pink: ligand for target protein CARM1/IKZF3 ligand 1 (HY-172369); Active form of target protein ligand: EZM 2302 (HY-111109); Black: linker (HY-21999); Blue: ligand for E3 ligase Cereblon Thalidomide 4-fluoride (HY-41547))
    PROTAC CARM1/IKZF3 degrader-1
  • HY-158157
    ZL-28-6

    		Histone Methyltransferase Cancer
    ZL-28-6 is a type I PRMT inhibitor (IC50: 18 nM). ZL-28-6 effectively targets CARM1 (a member of PRMT) within cells and can be used for cancer research [1].
    ZL-28-6
  • HY-111109
    EZM 2302
    Maximum Cited Publications
    8 Publications Verification

    		 Histone Methyltransferase Cancer
    EZM 2302 is an inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1) with an IC50 of 6 nM.
    EZM 2302
  • HY-100855
    DC_C66

    		Histone Methyltransferase Cancer
    DC_C66 is a cell-permeable, selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC50 of 1.8 μM. DC_C66 has a good selectivity for CARM1 against PRMT1 (IC50=21 μM), PRMT6 (IC50= 47μM), and PRMT5 [1].
    DC_C66
  • HY-114965
    TP-064
    5 Publications Verification

    		 Histone Methyltransferase Inflammation/Immunology Cancer
    TP-064 is a potent and selective proteinarginine methyltransferase 4 (PRMT4; CARM1) inhibitor (IC50 <10 nM). TP-064 inhibits dimethylation of BAF155 (IC50 of 340 nM) and MED12 (IC50 of 43 nM). TP-064 is inactive against the other family members except for PRMT6 (IC50 of 1.3 μM). TP-064 has anticancer activities [1].
    TP-064
  • HY-172370
    Thalidomide-NH-C4-Boc

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Thalidomide-NH-C4-Boc is the conjugate composed of an E3 ligase (Cereblon) ligand and a linker that can be used for synthesis of PROTAC CARM1/IKZF3 degrader-1 (HY-172368) [1].
    Thalidomide-NH-C4-Boc
  • HY-117927
    EPZ0025654

    GSK3536023

    		 Histone Methyltransferase Cancer
    EPZ0025654 (GSK3536023) is an inhibitor for protein arginine methyltransferases 4 (PRMT4) (which is also known as coactivator associated arginine methyltransferase 1 CARM1), with IC50 of 3 nM [1].
    EPZ0025654
  • HY-100565
    SGC2085
    1 Publications Verification

    		 Histone Methyltransferase Cancer
    SGC2085 is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC50 of 50 nM. SGC2085 also selectively inhibits PRMT6 with an IC50 value of 5.2 μM, but not other PRMT proteins [1].
    SGC2085
  • HY-100565A
    SGC2085 hydrochloride

    		Histone Methyltransferase Cancer
    SGC2085 hydrochloride is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC50 of 50 nM. SGC2085 hydrochloride also selectively inhibits PRMT6 with an IC50 value of 5.2 μM, but not other PRMT proteins [1].
    SGC2085 hydrochloride
  • HY-114206
    SKI-73

    		Histone Methyltransferase Cancer
    SKI-73 is a chemical probe for CARM1 with prodrug properties. SKI-73 can rapidly penetrate cell membranes and be processed into active inhibitors. SKI-73 inhibits the invasion of breast cancer cells and can be used in the study of cancer [1].
    SKI-73
  • HY-136809
    PRMT6-IN-2

    		Histone Methyltransferase Cancer
    PRMT6-IN-2 (compound 2) is a dual inhibitor of protein arginine methyltransferase PRMT6 and CARM1 with an IC50 of 30 nM. PRMT6 is abnormally expressed in many cancer cells, and PRMT6-IN-2-based derivatives have potential anticancer activity.
    PRMT6-IN-2
  • HY-W013500
    (1-Nitroethene-1,2-diyl)dibenzene

    alpha-Nitrostilbene; α-Nitrostilbene; NSC 385

    		 Histone Methyltransferase Others
    (1-Nitroethene-1,2-diyl)dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50=11 μM in histone H4 methylation assay). It also inhibits histone H4 methylation by PRMT8, but not histone H3.1 methylation by CARM1 or Set7/9, at concentrations of 10 and 100 μM.
    (1-Nitroethene-1,2-diyl)dibenzene
  • HY-110137A
    Furamidine

    DB75; NSC 305831

    		 Histone Methyltransferase Phosphodiesterase (PDE) Parasite Infection Inflammation/Immunology Cancer
    Furamidine (DB75) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine is also an antiparasite agent [1] .
    Furamidine
  • HY-110137
    Furamidine dihydrochloride
    2 Publications Verification

    DB75 dihydrochloride; NSC 305831 dihydrochloride

    		 Histone Methyltransferase Phosphodiesterase (PDE) Parasite Infection Inflammation/Immunology Cancer
    Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 283 μM, and >400 μM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent [1] .
    Furamidine dihydrochloride

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