2. Epigenetics
  3. Histone Methyltransferase
  4. EPZ0025654

EPZ0025654 (GSK3536023) is an inhibitor for protein arginine methyltransferases 4 (PRMT4) (which is also known as coactivator associated arginine methyltransferase 1 CARM1), with IC50 of 3 nM.

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EPZ0025654 Chemical Structure

EPZ0025654 Chemical Structure

CAS No. : 1888328-89-9

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EPZ0025654 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

EPZ0025654 (GSK3536023) is an inhibitor for protein arginine methyltransferases 4 (PRMT4) (which is also known as coactivator associated arginine methyltransferase 1 CARM1), with IC50 of 3 nM[1].

IC50 & Target

PRMT6

3 nM (IC50)

Molecular Weight

577.08

Formula

C29H33ClN8O3
CAS No.
SMILES

O[C@H](CNC)COC1=CC=C(Cl)C(C2=NC(C3=C(C)ON=C3C)=C(C)C(N4CC5=NC(N6CCC6)=NC=C5C4)=N2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EPZ0025654 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EPZ00256541888328-89-9GSK3536023EPZ 0025654EPZ-0025654GSK 3536023GSK-3536023Histone MethyltransferaseEZM2302multiple myelomaMMRPMI8226NCI-H929U266B1Inhibitorinhibitorinhibit

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HY-117927
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