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TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5; GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC50s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular Ca 2+ concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity .
CCDC39 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC39 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC78 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC78 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC152 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC152 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC66 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC66 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC93 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC93 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC92 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC92 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC57 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC57 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC3 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC15 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC8 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC14 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC80 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC80 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC91 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC91 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC51 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC51 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC127 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC127 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC71 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC71 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC69 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC69 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC146 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC146 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC115 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC115 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC30 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC30 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC170 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC170 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC7 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC17 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC17 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC86 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC86 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC40 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC40 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC82 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC82 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC137 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC137 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC124 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC124 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC22 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC22 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC6 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC103 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC103 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC24 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC24 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC141 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC141 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC34 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC34 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC9 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC47 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC47 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC18 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC18 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC25 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC25 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC50 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC50 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC134 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC134 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC144A Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC144A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC88A Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC88A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC88C Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC88C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC102B Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC102B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC9B Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC9B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC88B Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC88B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC90B Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC90B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CQ1373 is a potent RET inhibitor, demonstrating cellular potency with IC50 values of 13.0, 25.7 and 28.4 nM against BaF3 cells expressing CCDC6-RET, CCDC6-RET-G810C and CCDC6-RET-G810R, respectively. CQ1373 exhibits good selectivity toward wild-type RET and solvent front mutants G810C/R with IC50 values of 4.2, 7.1 and 32.4 nM, respectively. CQ1373 inhibits RET phosphorylation and downstream signaling through SHC. CQ1373 induces Apoptosis and cell cycle arrest in BaF3 cells. CQ1373 exhibits anti-tumor efficacy and can be used for cancer research .
Pralsetinib (BLU-667) is a highly potent, selective RET inhibitor. Pralsetinib (BLU-667) inhibits WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion with IC50s of 0.4, 0.3, 0.4, 0.4, and 0.4 nM, respectively .
RET-IN-29 (Compound 8W) is a selective RET kinase inhibitor. RET-IN-29 exhibits inhibitory potency against the BaF3 cells harboring CCDC6-RET V804M mutation with an IC50 value of 0.715 μM. RET-IN-29 is promising for research of non-small cell lung cancer (NSCLC) .
RET-IN-11 is a potent and selective RET inhibitor with IC50s of 6.20 nM, 18.68 nM for RET and RET V804M, respectively. RET-IN-11 shows anti-proliferation and migration activity in CCDC6-RET-driven LC-2/ad cells. RET-IN-11 induces cell apoptosis .
Pralsetinib (Standard) is the analytical standard of Pralsetinib. This product is intended for research and analytical applications. Pralsetinib (BLU-667) is a highly potent, selective RET inhibitor. Pralsetinib (BLU-667) inhibits WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion with IC50s of 0.4, 0.3, 0.4, 0.4, and 0.4 nM, respectively .
WF-47-JS03 is a potent and selective RET kinase inhibitor with IC50s of 1.7 nM and 5.3 nM for KIF5B-RET transfected Ba/F3 cells and CCDC6-RET transfected LC-2/ad lung cancer cells, respectively. WF-47-JS03 demonstrates >500-fold selectivity against kinase insert domain receptor (KDR). Effective brain penetration .
RET-IN-23 (compound 17) is a potent and orally active RET inhibitor with IC50 values of 1.32, 2.50, 6.54, 1.03, 1.47 nM for RET-WT, RET-CCDC6, RET-V804L, RET-V804M, RET-M918T, respectively. RET-IN-23 shows anti-tumor activity .
RET-IN-16 is a potent and selective RET inhibitor with IC50s of 3.98 nM, 8.42 nM, 15.05 nM, 7.86 nM, 5.43 nM and 8.86 nM for RET(WT), RET(M918T), RET(V804L), RET(V804M), RET-CCDC6 and RET-KIF5B, respectively. RET-IN-16 has anticancer effects .
The CCDC47 protein is an important component of the multichannel translocon (MPT) complex, which facilitates the insertion of multichannel membrane proteins into lipid bilayers. It blocks the lateral gate of the SEC61 complex, allowing insertion of subsequent transmembrane domains. CCDC47 Protein, Human (HEK293, His) is the recombinant human-derived CCDC47 protein, expressed by HEK293 , with C-His labeled tag.
The CCDC47 protein is an important component of the multichannel translocon (MPT) complex and cooperates with SEC61 to mediate the insertion of multichannel membrane proteins. As part of the PAT subcomplex within MPT, CCDC47 helps sequester polar regions within the transmembrane domain, ensuring correct membrane protein assembly. CCDC47 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CCDC47 protein, expressed by HEK293 , with C-His labeled tag. The total length of CCDC47 Protein, Mouse (HEK293, His) is 135 a.a., with molecular weight of ~20-23 KDa.
CCDC39 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC39 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC78 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC78 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC152 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC152 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC66 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC66 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC93 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC93 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC92 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC92 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC57 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC57 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC3 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC15 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC8 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC14 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC80 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC80 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC91 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC91 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC51 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC51 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC127 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC127 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC71 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC71 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC69 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC69 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC146 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC146 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC115 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC115 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC30 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC30 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC170 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC170 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC7 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC17 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC17 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC86 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC86 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC40 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC40 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC82 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC82 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC137 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC137 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC124 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC124 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC22 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC22 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC6 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC103 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC103 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC24 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC24 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC141 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC141 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC34 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC34 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC9 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC47 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC47 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC18 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC18 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC25 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC25 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC50 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC50 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC134 Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC134 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC144A Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC144A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC88A Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC88A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC88C Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC88C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC102B Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC102B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC9B Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC9B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC88B Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC88B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
CCDC90B Human Pre-designed siRNA Set A contains three designed siRNAs for CCDC90B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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