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Results for "

CD137 agonist

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

6

Inhibitory Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99056
    Utomilumab

    PF 05082566

    		 TNF Receptor Inflammation/Immunology Cancer
    Utomilumab (PF 05082566) is a fully human IgG2 agonist monoclonal antibody that selectively binds to 4-1BB/CD137. Utomilumab can be used in the research of tumors such as follicular and other CD20 + non-Hodgkin lymphomas .
    Utomilumab
  • HY-P99119
    Anti-Mouse 4-1BB/CD137 Antibody (3H3)

    		TNF Receptor Inflammation/Immunology
    Anti-Mouse 4-1BB/CD137 Antibody (3H3) is an IgG2a antibody agonist against mouse 4-1BB, derived from a rat host, capable of stimulating 4-1BB signaling in vivo.
    Anti-Mouse 4-1BB/CD137 Antibody (3H3)
  • HY-P99055
    Urelumab

    		TNF Receptor Inflammation/Immunology Cancer
    Urelumab, a fully human, non-ligand binding, CD137 agonist IgG4 monoclonal antibody, enhances T-cell and natural killer-cell antitumor activity, and may enhance cytotoxic activity of Rituximab (HY-P9913). Urelumab can be used for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and other types of non-Hodgkin lymphoma (NHL) .
    Urelumab
  • HY-161982
    JNU-0921

    		TNF Receptor Cancer
    JNU-0921 is a potent and orally active CD137 agonist. JNU-0921 increases the mRNA expression of IFN-γ and GZMB. JNU-0921 induces luciferase activity with an EC50 value of 64.07 nM.JNU-0921 enhances effector and memory function of cytotoxic CD8 + T cells (CTLs) and alleviates their exhaustion. JNU-0921 also skews polarization of helper T cells toward T helper 1 type and enhances their activity to boost CTL function. JNU-0921 shows anticancer activity .
    JNU-0921
  • HY-P99119A
    Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3)

    		Transmembrane Glycoprotein Others
    Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3) is a mouse-derived IgG2a, κ type antibody agonist, targeting to mouse 4-1BB/CD137.
    Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3)
  • HY-P991087
    RO7122290

    		FAP Cancer
    RO7122290 is a bispecific fusion protein carrying a split trimeric 4-1BB (CD137) ligand and a fibroblast activation protein α (FAP) binding site. O7122290 is a FAP-α-targeted 4-1BB agonist that costimulates T cells for improved tumor cell killing in FAP-expressing tumors .
    RO7122290
  • HY-P991070
    ADG-106

    		TNF Receptor Cancer
    ADG-106 is a fully human agonistic monoclonal IgG4 antibody against CD137 (4-1BB). ADG-106 has the mechanism to activate CD137 via strong FcγRIIB-mediated crosslinking while antagonizing CD137 ligands. The isotype control for ADG-106 can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
    ADG-106

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