2. Apoptosis
  3. TNF Receptor
  4. JNU-0921

JNU-0921 is a potent and orally active CD137 inhibitor. JNU-0921 increases the mRNA expression of IFN-γ and GZMB. JNU-0921 induces luciferase activity with an EC50 value of 64.07 nM.JNU-0921 enhances effector and memory function of cytotoxic CD8+ T cells (CTLs) and alleviates their exhaustion. JNU-0921 also skews polarization of helper T cells toward T helper 1 type and enhances their activity to boost CTL function. JNU-0921 shows anticancer activity.

For research use only. We do not sell to patients.

JNU-0921 Chemical Structure

JNU-0921 Chemical Structure

Size Price Stock Quantity
5 mg USD 200 In-stock
10 mg USD 320 In-stock
25 mg USD 640 In-stock
50 mg USD 1024 In-stock
100 mg USD 1635 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

JNU-0921 Related Antibodies

Top Publications Citing Use of Products

View All TNF Receptor Isoform Specific Products:

View All Isoforms
TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Description

JNU-0921 is a potent and orally active CD137 inhibitor. JNU-0921 increases the mRNA expression of IFN-γ and GZMB. JNU-0921 induces luciferase activity with an EC50 value of 64.07 nM.JNU-0921 enhances effector and memory function of cytotoxic CD8+ T cells (CTLs) and alleviates their exhaustion. JNU-0921 also skews polarization of helper T cells toward T helper 1 type and enhances their activity to boost CTL function. JNU-0921 shows anticancer activity[1].

Molecular Weight

316.31

Formula

C19H12N2O3
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC(C2=NOC(C3=CC(C=CC=C4)=C4C=C3)=N2)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (158.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1615 mL 15.8073 mL 31.6146 mL
5 mM 0.6323 mL 3.1615 mL 6.3229 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1615 mL 15.8073 mL 31.6146 mL 79.0364 mL
5 mM 0.6323 mL 3.1615 mL 6.3229 mL 15.8073 mL
10 mM 0.3161 mL 1.5807 mL 3.1615 mL 7.9036 mL
15 mM 0.2108 mL 1.0538 mL 2.1076 mL 5.2691 mL
20 mM 0.1581 mL 0.7904 mL 1.5807 mL 3.9518 mL
25 mM 0.1265 mL 0.6323 mL 1.2646 mL 3.1615 mL
30 mM 0.1054 mL 0.5269 mL 1.0538 mL 2.6345 mL
40 mM 0.0790 mL 0.3952 mL 0.7904 mL 1.9759 mL
50 mM 0.0632 mL 0.3161 mL 0.6323 mL 1.5807 mL
60 mM 0.0527 mL 0.2635 mL 0.5269 mL 1.3173 mL
80 mM 0.0395 mL 0.1976 mL 0.3952 mL 0.9880 mL
100 mM 0.0316 mL 0.1581 mL 0.3161 mL 0.7904 mL
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JNU-0921 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNU-0921JNU0921JNU 0921TNF ReceptorTumor Necrosis Factor ReceptorTNFRJC-luc cellsMC38 allograft tumororally activeCTLIFN-γGZMBanticancerInhibitorinhibitorinhibit

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