CDC37

By Targets:	Apoptosis (6) HSP (8) Necroptosis (1) RIP kinase (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (8) Inflammation/Immunology (3)
Oligonucleotides:	Pre-designed siRNA Sets (2) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144650

*Hsp90-Cdc37-IN-3*	Apoptosis HSP	Cancer
Hsp90-Cdc37-IN-3 (Compound 9) is a novel celastrol−imidazole derivative with anticancer activity. Hsp90-Cdc37-IN-3 inhibits *Hsp90−Cdc37* by covalent-binding, and induces apoptosis .

HY-111414

*Hsp90-Cdc37-IN-1*	HSP	Cancer
Hsp90-Cdc37-IN-1 is an *Hsp90-Cdc37* interaction disruptor that inhibit cell migration and reverse agent resistance, with an IC₅₀ of 140 nM.

HY-139301

DDO-5936 1 Publications Verification	HSP	Cancer
DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. DDO-5936 can be used for the research of colorectal cancer .

HY-119906

Conglobatin FW-04-806	HSP Apoptosis	Cancer
Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. Conglobatin is an orally active Hsp90 inhibitor. Conglobatin can bind to the N-terminal domain of Hsp90 and disrupt Hsp90-Cdc37 complex formation. Conglobatin induces apoptosis in human breast cancer cells and esophageal squamous cell carcinoma cells, and exhibits antitumor activity in vivo .

HY-N1986

Cucurbitacin D	HSP Apoptosis	Inflammation/Immunology Cancer
Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis, exhibiting anti-tumor and anti-inflammatory effects .

HY-N3417

Kongensin A 1 Publications Verification	HSP RIP kinase Apoptosis Necroptosis	Inflammation/Immunology Cancer
Kongensin A is a natural product isolated from Croton kongensis. Kongensin A is an effective, covalent HSP90 inhibitor that blocks RIP3-dependent necroptosishas. Kongensin A is a potent necroptosis inhibitor and an apoptosis inducer. Kongensin A has potential anti-necroptosis and anti-inflammation applications .

HY-RS02297

CDC37 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CDC37 Human Pre-designed siRNA Set A contains three designed siRNAs for CDC37 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CDC37 Human Pre-designed siRNA Set A CDC37 Human Pre-designed siRNA Set A

HY-RS02298

CDC37L1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CDC37L1 Human Pre-designed siRNA Set A contains three designed siRNAs for CDC37L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CDC37L1 Human Pre-designed siRNA Set A CDC37L1 Human Pre-designed siRNA Set A

HY-130624

*Hsp90-Cdc37-IN-2*	HSP Apoptosis	Cancer
Hsp90-Cdc37-IN-2 (Compound 41) is an inhibitor for the interaction between heat shock protein 90 (Hsp90) and cyclin 37 (Cdc37). Hsp90-Cdc37-IN-2 inhibits the proliferation of cancer cell A549, MCF-7, HOS and HepG2 with IC₅₀ of 0.41-0.94 μM. Hsp90-Cdc37-IN-2 decreases the mitochondrial membrane potential, induces apoptosis, and arrest cell cycle at G0/G1 phase in A549 .

HY-N1986R

Cucurbitacin D (Standard)	HSP Apoptosis	Inflammation/Immunology Cancer
Cucurbitacin D (Standard) is the analytical standard of Cucurbitacin D. This product is intended for research and analytical applications. Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis, exhibiting anti-tumor and anti-inflammatory effects .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-119906

Conglobatin FW-04-806	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	HSP Apoptosis
Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. Conglobatin is an orally active Hsp90 inhibitor. Conglobatin can bind to the N-terminal domain of Hsp90 and disrupt Hsp90-Cdc37 complex formation. Conglobatin induces apoptosis in human breast cancer cells and esophageal squamous cell carcinoma cells, and exhibits antitumor activity in vivo .

HY-N1986

Cucurbitacin D	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Trichosanthes kirilowii Maxim. Plants Disease Research Fields Cancer	HSP Apoptosis
Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis, exhibiting anti-tumor and anti-inflammatory effects .

HY-N3417

Kongensin A 1 Publications Verification	Classification of Application Fields Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields Croton kongensis Gagnep.	HSP RIP kinase Apoptosis Necroptosis
Kongensin A is a natural product isolated from Croton kongensis. Kongensin A is an effective, covalent HSP90 inhibitor that blocks RIP3-dependent necroptosishas. Kongensin A is a potent necroptosis inhibitor and an apoptosis inducer. Kongensin A has potential anti-necroptosis and anti-inflammation applications .

HY-N1986R

Cucurbitacin D (Standard)	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Trichosanthes kirilowii Maxim. Plants	HSP Apoptosis
Cucurbitacin D (Standard) is the analytical standard of Cucurbitacin D. This product is intended for research and analytical applications. Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis, exhibiting anti-tumor and anti-inflammatory effects .

Species:	Human (1) Mouse (2)
Tag:	His (1) Tag Free (1) GST (2)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P75364

	CDC37 Protein, Human (sf9, GST) Hsp90 co-chaperone CDC37; CDC37; CDC37A	Human	Sf9 insect cells
	The CDC37 protein is a co-chaperone that binds multiple kinases and promotes their interaction with the Hsp90 complex, resulting in stability and enhanced activity. CDC37 Protein, Human (sf9, GST) is the recombinant human-derived CDC37 protein, expressed by Sf9 insect cells , with C-GST labeled tag. The total length of CDC37 Protein, Human (sf9, GST) is 378 a.a., with molecular weight of ~70.7 kDa.

HY-P75363

	CDC37 Protein, Mouse (sf9) Hsp90 co-chaperone CDC37; CDC37; CDC37A	Mouse	Sf9 insect cells
	The CDC37 protein is a co-chaperone that binds to kinases and promotes their interaction with Hsp90 complexes, thereby stabilizing and activating them. It inhibits the ATPase activity of HSP90AA1. CDC37 Protein, Mouse (sf9) is the recombinant mouse-derived CDC37 protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes), , , , mutation. The total length of CDC37 Protein, Mouse (sf9) is 379 a.a., with molecular weight of ~46 kDa.

HY-P75362

	CDC37 Protein, Mouse (sf9, His-GST) Hsp90 co-chaperone CDC37; CDC37; CDC37A	Mouse	Sf9 insect cells
	The CDC37 protein is a co-chaperone that binds to kinases and promotes their interaction with Hsp90 complexes, thereby stabilizing and activating them. It inhibits the ATPase activity of HSP90AA1. CDC37 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CDC37 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CDC37 Protein, Mouse (sf9, His-GST) is 379 a.a., with molecular weight of ~66 kDa.

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HY-P80960

	CDC37 Antibody	WB, IHC-P, IP, FC	Human, Mouse, Rat
	CDC37 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 44 kDa, targeting to Hsp90 co-chaperone Cdc37 (CDC37). It can be used for WB,IHC-P,IP,FC assays in the background of Human, Mouse, Rat.

HY-P80962

	*Phospho-CDC37* (Ser13) Antibody (YA219)**	WB, IP	Human, Mouse, Rat
	Phospho-CDC37 (Ser13) Antibody (YA219) is a non-conjugated and Rabbit origined monoclonal antibody about 44 kDa, targeting to Hsp90 co-chaperone Cdc37 (CDC37). It can be used for WB,IP assays in the background of Human, Mouse, Rat.

HY-P80961

	*Phospho-CDC37* (Ser13) Antibody**	WB, IP	Human, Mouse, Rat
	Phospho-CDC37 (Ser13) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 44 kDa, targeting to Hsp90 co-chaperone Cdc37 (CDC37). It can be used for WB,IP assays in the background of Human, Mouse, Rat.

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Cat. No.	Product Name		Classification

HY-RS02297

CDC37 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
CDC37 Human Pre-designed siRNA Set A contains three designed siRNAs for CDC37 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS02298

CDC37L1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
CDC37L1 Human Pre-designed siRNA Set A contains three designed siRNAs for CDC37L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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CDC37

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