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CP-597396 hydrochloride

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-105064D
    Zoniporide hydrochloride hydrate
    1 Publications Verification

    CP-597396 hydrochloride hydrate

    		 Na+/H+ Exchanger (NHE) Cardiovascular Disease
    Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC50=59 nM) .
    Zoniporide hydrochloride hydrate
  • HY-105064
    Zoniporide
    1 Publications Verification

    CP-597396

    		 Na+/H+ Exchanger (NHE) Cardiovascular Disease
    Zoniporide (CP-597396) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22Na + uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC50=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease .
    Zoniporide
  • HY-105064B
    Zoniporide hydrochloride

    CP-597396 hydrochloride

    		 Na+/H+ Exchanger (NHE) Cardiovascular Disease
    Zoniporide (CP-597396) hydrochloride is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride inhibits human NHE-1 (IC50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC50=59 nM) .
    Zoniporide hydrochloride
  • HY-105064C
    Zoniporide dihydrochloride

    CP-597396 dihydrochloride

    		 Na+/H+ Exchanger (NHE) Cancer
    Zoniporide dihydrochloride (CP-597396 dihydrochloride) is a potent and selective inhibitor of highly water-soluble sodium hydrogen exchange type 1 (NHE-1). Zoniporide dihydrochloride inhibits NHE1 dependent 22Na + uptake in vitro with an IC50 of 14 nM. Zoniporide has antitumor activity .
    Zoniporide dihydrochloride

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