2. Membrane Transporter/Ion Channel
  3. Na+/H+ Exchanger (NHE)
  4. Zoniporide

Zoniporide  (Synonyms: CP-597396)

Cat. No.: HY-105064 Purity: 99.89%
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Zoniporide (CP-597396) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22Na+ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC50=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease.

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Zoniporide Chemical Structure

Zoniporide Chemical Structure

CAS No. : 241800-98-6

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5 mg USD 130 In-stock
10 mg USD 210 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Zoniporide:

Zoniporide Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Zoniporide

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Description

Zoniporide (CP-597396) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22Na+ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC50=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease[1].

Molecular Weight

320.35

Formula

C17H16N6O
CAS No.
Appearance

Solid

SMILES

N=C(N)NC(C1=C(C2CC2)N(C3=C4C(N=CC=C4)=CC=C3)N=C1)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (390.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1216 mL 15.6079 mL 31.2159 mL
5 mM 0.6243 mL 3.1216 mL 6.2432 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1216 mL 15.6079 mL 31.2159 mL 78.0396 mL
5 mM 0.6243 mL 3.1216 mL 6.2432 mL 15.6079 mL
10 mM 0.3122 mL 1.5608 mL 3.1216 mL 7.8040 mL
15 mM 0.2081 mL 1.0405 mL 2.0811 mL 5.2026 mL
20 mM 0.1561 mL 0.7804 mL 1.5608 mL 3.9020 mL
25 mM 0.1249 mL 0.6243 mL 1.2486 mL 3.1216 mL
30 mM 0.1041 mL 0.5203 mL 1.0405 mL 2.6013 mL
40 mM 0.0780 mL 0.3902 mL 0.7804 mL 1.9510 mL
50 mM 0.0624 mL 0.3122 mL 0.6243 mL 1.5608 mL
60 mM 0.0520 mL 0.2601 mL 0.5203 mL 1.3007 mL
80 mM 0.0390 mL 0.1951 mL 0.3902 mL 0.9755 mL
100 mM 0.0312 mL 0.1561 mL 0.3122 mL 0.7804 mL
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Zoniporide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zoniporide241800-98-6CP-597396CP597396CP 597396Na+/H+ Exchanger (NHE)Sodium/hydrogen ExchangerSodium-hydrogen ExchangerCardioprotectionfibroblastsplatelet swellingcardiovascular diseaseinhibitorInhibitorinhibit

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