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CYP7A1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apical Sodium-Dependent Bile Acid Transporter (1) Bacterial (1) Cytochrome P450 (4) Endogenous Metabolite (1) FXR (2) PPAR (1) RAR/RXR (1) ROR (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cardiovascular Disease (1) Infection (1) Metabolic Disease (6)
Oligonucleotides:	Human Pre-designed siRNA Sets (2) siRNAs (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-163436

F44-A13	FXR Cytochrome P450 RAR/RXR PPAR ROR	Metabolic Disease
F44-A13 is an orally active and highly selective farnesoid X receptor (FXR) antagonist with an IC₅₀ value of 1.1 μM. F44-A13 can optimize cholesterol metabolism and reduce its activity by inducing *CYP7A1* expression. F44-A13 reduces levels of cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) in mouse models. F44-A13 can be used in the study of metabolic diseases associated with lipid disorders .

HY-W008226

Phloracetophenone 2,4,6-trihydroxyacetophenone; 1-(2,4,6-Trihydroxyphenyl)ethanone	Cytochrome P450 Bacterial Antibiotic	Infection Metabolic Disease
Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity . Phloracetophenone stimulats bile secretion mediated through Mrp2 .

HY-117147A

GSK2945 hydrochloride	Cytochrome P450	Metabolic Disease
GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC₅₀s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism .

HY-113259

7α-Hydroxy-4-cholesten-3-one	Endogenous Metabolite	Metabolic Disease
7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1 .

HY-RS03487

CYP7A1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CYP7A1 Human Pre-designed siRNA Set A contains three designed siRNAs for CYP7A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CYP7A1 Human Pre-designed siRNA Set A CYP7A1 Human Pre-designed siRNA Set A

HY-19264

264W94	Apical Sodium-Dependent Bile Acid Transporter	Metabolic Disease
264W94 is a potent ileal bile acid transporter (IBAT) inhibitor and a new cholesterol lowering agent. 264W94 has CYP7A1 induction, and antilipemic action .

HY-168331

FXR agonist 10	FXR	Others
FXR agonist 10 (Compound 27) is an agonist for FXR with an EC₅₀ of 14.26 μM. FXR agonist 10 upregulates the expression of SHP and BSEP proteins, downregulates the expression of NTCP and CYP7A1 proteins. FXR agonist 10 ameliorates the ANIT-induced cholestasis in mouse model .

HY-117147

GSK2945	Cytochrome P450	Metabolic Disease
GSK2945 is a class of tertiary amine, and is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC₅₀s of 21.5 μM and 20.8 μM, respectively. GSK2945 enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism .

HY-N13218

Pueraria Extract	Others	Cardiovascular Disease
Pueraria Extract is a kudzu extract, and its components include: Isoflavones. Pueraria Extract (ethanol extract) can significantly improve cardiac damage in rats with acute myocardial infarction. Pueraria Extract improves bile acid levels by increasing the expression of CYP7A1 and restoring the diversity of intestinal microbiota. Pueraria Extract can also inhibit the FXR-FGF15 signaling pathway and increase the expression of OST-α to increase bile acid reabsorption and fecal excretion. .

HY-RS03488

CYP7B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CYP7B1 Human Pre-designed siRNA Set A contains three designed siRNAs for CYP7B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CYP7B1 Human Pre-designed siRNA Set A CYP7B1 Human Pre-designed siRNA Set A

Phloracetophenone 2,4,6-trihydroxyacetophenone; 1-(2,4,6-Trihydroxyphenyl)ethanone	Structural Classification Classification of Application Fields Source classification Metabolic Disease Plants Curcuma comosa Roxb. Infection other families Ketones, Aldehydes, Acids Phenols Polyphenols Disease Research Fields Zingiberaceae	Cytochrome P450 Bacterial Antibiotic
Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity . Phloracetophenone stimulats bile secretion mediated through Mrp2 .

7α-Hydroxy-4-cholesten-3-one	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1 .

Cat. No.	Compare	Product Name	Species	Source

HY-P702798

	CYP7A1 Protein, Human (His) Cytochrome P450 7A1; 24-hydroxycholesterol 7-alpha-hydroxylase; CYPVII; Cholesterol 7-alpha-hydroxylase	Human	E. coli
	CYP7A1 Protein, Human (His) is the recombinant human-derived CYP7A1, expressed by E. coli , with N-6*His labeled tag. The total length of CYP7A1 Protein, Human (His) is 504 a.a.,

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CYP7A1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CYP7A1 Human Pre-designed siRNA Set A contains three designed siRNAs for CYP7A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CYP7B1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CYP7B1 Human Pre-designed siRNA Set A contains three designed siRNAs for CYP7B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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