Cadpr

By Targets:	Biochemical Assay Reagents (1) Calcium Channel (4) Caspase (2) CD38 (1) Endogenous Metabolite (2) Small Interfering RNA (siRNA) (2) Toll-like Receptor (TLR) (1) TRP Channel (3)
By Research Areas:	Cancer (1) Cardiovascular Disease (4) Endocrinology (2) Infection (2) Inflammation/Immunology (3) Neurological Disease (6)
Click Chemistry:	Azide (1)
Oligonucleotides:	siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7395

Cyclic ADP-ribose Cadpr	Calcium Channel TRP Channel Endogenous Metabolite	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

HY-N7395A

Cyclic ADP-ribose ammonium Cadpr ammonium	Calcium Channel TRP Channel Endogenous Metabolite	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

HY-Z0816

Dehydronitrosonisoldipine 2 Publications Verification	Calcium Channel	Others
Dehydronitrosonisoldipine, a derivative of Nisoldipine (HY-17402), is an irreversible and cell-permeant sterile alpha and TIR motif-containing 1 (SARM1) inhibitor. Dehydronitrosonisoldipine acts mainly by blocking SARM1 activation but not its enzymatic activities. Dehydronitrosonisoldipine inhibits SARM1 and axon degenration (AxD) by covalently modifying cysteines, also inhibits the Vincristine-activated cADPR production in neurons. Dehydronitrosonisoldipine can be used for researching neurodegenerative disorders .

HY-W021879

DSRM-3716 3 Publications Verification 5-Iodoisoquinoline	Others	Neurological Disease
DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC₅₀ of 75 nM. DSRM-3716 is selective against other NAD ⁺-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection .

HY-129522

Sulfo-ara-F-NMN 2 Publications Verification CZ-48	Toll-like Receptor (TLR)	Neurological Disease
Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC₅₀ around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production .

HY-134269

8-Br-7-CH-cADPR 7-Deaza-8-bromo-Cadpr; 7-Deaza-8-bromo-cyclic ADP ribose	Calcium Channel	Neurological Disease
8-Br-7-CH-cADPR (7-Deaza-8-bromo-cADPR) is a potent *cADPR* antagonist. 8-Br-7-CH-cADPR shows partial inhibition of calcium elevation caused by sTIR dimerization. 8-Br-7-CH-cADPR significantly decreases Paclitaxel (HY-B0015)-induced axon degeneration .

HY-117804

8-Br-cADPR 8-Bromo-Cyclic ADP-Ribose	TRP Channel	Neurological Disease
8-Br-cADPR is a potent *cADPR* antagonist. 8-Br-cADPR reduces renal damage and the expression of caspase-3 and TRPM2 .

HY-134280

8-Br-NHD+ Nicotinamide 8-Br-hypoxanthine dinucleotide	Others	Others
8-Br-NHD+ (Nicotinamide 8-Br-hypoxanthine dinucleotide) is a derivative of NAD+ (nicotinamide adenine dinucleotide) that acts as a potential substrate, competitive inhibitor or modulator of enzymes that interact with β-NAD+. 8-Br-NHD+ can be used to synthesize a cyclic ADP nucleotide (cADPR) analog .

HY-P990037

Erzotabart	CD38	Cancer
Erzotabart is an IgG1-kappa, anti-CD38 (ADP-ribosyl cyclase 1, cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, cADPR1) Homo sapiens monoclonal antibody. Erzotabart shows antineoplastic activity .

HY-158820

Cosdosiran QPI-1007	Small Interfering RNA (siRNA) Caspase	Cardiovascular Disease
Cosdosiran is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?

HY-158820A

Cosdosiran sodium QPI-1007 sodium	Small Interfering RNA (siRNA) Caspase	Cardiovascular Disease
Cosdosiran sodium is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?

HY-E70364

IgdE protease	Biochemical Assay Reagents	Inflammation/Immunology
IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage .

Cat. No.	Product Name	Target	Research Area

HY-P990037

Erzotabart	CD38	Cancer
Erzotabart is an IgG1-kappa, anti-CD38 (ADP-ribosyl cyclase 1, cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, cADPR1) Homo sapiens monoclonal antibody. Erzotabart shows antineoplastic activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7395

Cyclic ADP-ribose Cadpr	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology	Calcium Channel TRP Channel Endogenous Metabolite
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

HY-N7395A

Cyclic ADP-ribose ammonium Cadpr ammonium	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Endocrinology	Calcium Channel TRP Channel Endogenous Metabolite
Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD ⁺ by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .

Species:	Human (3)
Tag:	His (2) Avi (1) Fc (1)
Source:	HEK293 (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P72356

	CD38 Protein, Human (Biotinylated, HEK293, His-Avi) ADP-ribosyl cyclase1; 2'-phospho-ADP-ribosyl cyclase; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1; Cadpr hydrolase 1	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD38 protein, expressed by HEK293 , with N-Avi, N-6*His labeled tag. The total length of CD38 Protein, Human (Biotinylated, HEK293, His-Avi) is 258 a.a., with molecular weight of 40-50 kDa.

HY-P78650

	FITC-Labeled CD38 Protein, Human (HEK293, His) CD38; T10; Cadpr hydrolase 1	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). FITC-Labeled CD38 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled CD38 protein, expressed by HEK293 , with C-His labeled tag. The total length of FITC-Labeled CD38 Protein, Human (HEK293, His) is 258 a.a., with molecular weight of 40-50 kDa.

HY-P701286

	FITC-Labeled CD38 Protein, Human (HEK293, Fc) CD38; T10; Cadpr hydrolase 1	Human	HEK293
	The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). FITC-Labeled CD38 Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-Labeled CD38 protein, expressed by HEK293 , with Fc labeled tag. The total length of FITC-Labeled CD38 Protein, Human (HEK293, Fc) is 258 a.a., with molecular weight of 65-75 KDa.

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Cat. No.	Product Name		Classification

HY-147150

8-Azido-cADPR		Azide
8-Azido-cADPR, with its photoactive azido group, is a potent photoaffinity probe. 8-Azido-cADPR can be used for the identification and characterization of cADPR-binding proteins . 8-Azido-cADPR is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-158820

Cosdosiran QPI-1007		siRNAs
Cosdosiran is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?

HY-158820A

Cosdosiran sodium QPI-1007 sodium		siRNAs
Cosdosiran sodium is a chemically modified siRNA designed to temporarily inhibit expression of the caspase 2 protein and can be used for the study of nonarteritic anterior ischemic optic neuropathy and other optic neuropathies such as glaucoma that result in the death of retinal ganglion cells.?

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Cadpr

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