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Results for "

DNA-crosslinking

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA Alkylator/Crosslinker (14) DNA/RNA Synthesis (4) ADC Cytotoxin (3) Apoptosis (10) Autophagy (1) Bacterial (1) Drug Metabolite (1) Drug-Linker Conjugates for ADC (1) E1/E2/E3 Enzyme (1) Isotope-Labeled Compounds (3) MDM-2/p53 (1)
By Research Areas:	Cancer (23) Infection (1)

Inhibitors & Agonists

Peptides

Isotope-Labeled Compounds

Targets Recommended: DNA-PK DNA Methyltransferase DNA Stain DNA Alkylator/Crosslinker DNA/RNA Synthesis

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W010342

6-Aminonicotinamide 5+ Cited Publications	Others	Cancer
6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP ⁺-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (K_i=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin, in killing cancer cells .

HY-14573

SJG-136 3 Publications Verification NSC-694501	DNA Alkylator/Crosslinker ADC Cytotoxin	Cancer
SJG-136 is a *DNA cross-linking* agent, with an XL₅₀ of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity.

HY-13424

RITA 3 Publications Verification NSC 652287	MDM-2/p53 Autophagy DNA Alkylator/Crosslinker	Cancer
RITA is an inhibitor of p53-HDM-2 interaction, binds to p53dN, with a K_d of 1.5 nM, and also induces DNA-DNA cross-links.

HY-17371

Oxaliplatin Maximum Cited Publications 113 Publications Verification	DNA/RNA Synthesis Apoptosis	Cancer
Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Oxaliplatin can be used for cancer research .

HY-101162

SGD-1910	Drug-Linker Conjugates for ADC	Cancer
SGD-1910 is a *agent-linker* conjugate for ADC** by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala .

HY-B0077

Bendamustine hydrochloride 4 Publications Verification SDX-105	DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine hydrochloride (SDX-105), a purine analogue, is a *DNA cross-linking* agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

HY-13567

Bendamustine 4 Publications Verification SDX-105 free base	DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine (SDX-105 free base), a purine analogue, is a *DNA cross-linking* agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .

HY-139635

Anticancer agent 11	DNA Alkylator/Crosslinker	Cancer
Anticancer agent 11 is a broad-spectrum anticancer agent that inhibits angiogenesis and induces *DNA cross-links*.

HY-13567S

Bendamustine-d4 SDX-105-d₄ free base	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Bendamustine-d₄ is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.

HY-17371A

(rel)-Oxaliplatin	DNA/RNA Synthesis Apoptosis	Cancer
(rel)-Oxaliplatin is a DNA synthesis inhibitor. (rel)-Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. (rel)-Oxaliplatin can be used for cancer research .

HY-402091

SJG-136 intermediate-1	ADC Cytotoxin	Others
SJG-136 intermediate-1 (compound 19) is an intermediate for synthesizing SJG-136. SJG-136 is a DNA cross-linking agent, with an XL₅₀ of 45 nM for pBR322 DNA .

HY-402090

SJG-136 intermediate-2	ADC Cytotoxin	Others
SJG-136 intermediate-2 (compound 141) is an intermediate for synthesizing SJG-136. SJG-136 is a DNA cross-linking agent, with an XL₅₀ of 45 nM for pBR322 DNA .

HY-13703A

Nimustine hydrochloride 1 Publications Verification ACNU	DNA/RNA Synthesis DNA Alkylator/Crosslinker Apoptosis	Cancer
Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly used in chemotherapy for glioblastomas .

HY-126539

UBE2T/FANCL-IN-1	E1/E2/E3 Enzyme	Cancer
UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin .

HY-17371R

Oxaliplatin (Standard)	DNA/RNA Synthesis Apoptosis	Cancer
Oxaliplatin (Standard) is the analytical standard of Oxaliplatin. This product is intended for research and analytical applications. Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Oxaliplatin can be used for cancer research .

HY-124325

PIP-199	DNA Alkylator/Crosslinker	Cancer
PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC₅₀ of 36 μM. PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics .

HY-B0077S1

Bendamustine-d8 hydrochloride SDX-105-d₈	Isotope-Labeled Compounds DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine-d₈ (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties[1].

HY-17371S

Oxaliplatin-d10	Isotope-Labeled Compounds	Cancer
Oxaliplatin-d₁₀ is a deuterium labeled Oxaliplatin (HY-17371). Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Oxaliplatin can be used for cancer research .

HY-B0077R

Bendamustine hydrochloride (Standard)	DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine (hydrochloride) (Standard) is the analytical standard of Bendamustine (hydrochloride). This product is intended for research and analytical applications. Bendamustine hydrochloride (SDX-105), a purine analogue, is a *DNA cross-linking* agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .

HY-16406

PR-104 sodium	DNA Alkylator/Crosslinker	Cancer
PR-104 (sodium) is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104 (sodium), as a nitrogen mustard pre-proagent, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A .

HY-16405

PR-104	DNA Alkylator/Crosslinker	Cancer
PR-104 is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104, as a nitrogen mustard pre-proagent, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A .

HY-13567S1

Bendamustine-d8 SDX-105-d₈ free base	DNA Alkylator/Crosslinker Apoptosis	Cancer
Bendamustine-d₈ is the deuterium labeled Bendamustine[1]. Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties[2].

HY-117909

CEP-40125 RXDX-107	Apoptosis	Cancer
CEP-40125 (RXDX-107) is a modified form of Bendamustine (HY-13567), a DNA cross-linking agent that may cause DNA damage and cell apoptosis. CEP-40125 (RXDX-107) is formed by encapsulating the alkyl ester form of Bendamustine in human serum albumin .

HY-W781133

cDPCP cis-[Pt(NH3)2(N1-pyridine)Cl]Cl	Others	Cancer
cDPCP (cis-[Pt(NH3)2(N1-pyridine)Cl]Cl) is a DNA crosslinking agent and also a substrate for OCT1 and OCT2. DPCP exhibits anticancer activity and can improve the survival rate of sarcoma-180 mice. cDPCP is suitable for the research of colorectal cancer and cancers with appropriate cation transporters .

HY-P3350

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

HY-14572

PR-104A SN 27858	DNA Alkylator/Crosslinker Drug Metabolite	Cancer
PR-104A (SN 27858) is the alcohol metabolite of phosphate proagent PR-104. PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin. Antitumor Activity . PR-104A is metabolized under hypoxia by the 1-electron NADPH:cytochrome P450 oxidoreductase. PR-104A can be used for the research of relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL) .

Cat. No.	Product Name	Target	Research Area

HY-P3350

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

Cat. No.	Product Name	Chemical Structure

HY-13567S

Bendamustine-d4
Bendamustine-d₄ is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.

HY-B0077S1

Bendamustine-d8 hydrochloride
Bendamustine-d₈ (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties[1].

HY-17371S

Oxaliplatin-d10
Oxaliplatin-d₁₀ is a deuterium labeled Oxaliplatin (HY-17371). Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Oxaliplatin can be used for cancer research .

HY-13567S1

Bendamustine-d8
Bendamustine-d₈ is the deuterium labeled Bendamustine[1]. Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties[2].

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