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Results for "

DSP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) ADC Linker (1) Adrenergic Receptor (2) Bacterial (1) Epigenetic Reader Domain (1) GABA Receptor (1) Isotope-Labeled Compounds (1) Serotonin Transporter (2) SGLT (2) Small Interfering RNA (siRNA) (2) Sodium Channel (1) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (8)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103210

DSP-4 hydrochloride 1 Publications Verification Neurotoxin DSP 4 hydrochloride	Adrenergic Receptor	Neurological Disease
DSP-4 hydrochloride is a highly and selective adrenergic neurotoxin. DSP-4 hydrochloride can cross the blood brain barrier. DSP-4 hydrochloride can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons .

HY-111419

DSP-1053	Serotonin Transporter 5-HT Receptor	Neurological Disease
DSP-1053, a benzylpiperidine derivative, is a potent Serotonin Transporter (SERT) inhibitor with a K_i of 1.02 nM. DSP-1053 shows partial 5-HT_1A receptor agonistic activity with a K_i of 5.05 nM. DSP-1053 has antidepressant activity .

HY-125079

DSP-2230	Sodium Channel	Cardiovascular Disease Neurological Disease
DSP-2230 is a selective Nav1.7/Nav1.8 blocker, can be used to improve neuropathic pain .

HY-118759

DSP Crosslinker 1 Publications Verification	ADC Linker	Inflammation/Immunology
DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs) .

HY-111419A

DSP-1053 benzenesulfonate	Serotonin Transporter 5-HT Receptor	Neurological Disease
DSP-1053, a benzylpiperidine derivative, is a potent serotonin transporter (SERT) inhibitor with a K_i of 1.02 nM. DSP-1053 shows partial 5-HT_1A receptor agonistic activity with a K_i of 5.05 nM. DSP-1053 has antidepressant activity .

HY-163728

DSP-6745	5-HT Receptor	Neurological Disease
DSP-6745 is a potent and orally active 5-HT Receptor inhibitor. DSP-6745 can be used in the study of depressive disorder .

HY-114300

DSP-0565	GABA Receptor	Neurological Disease
DSP-0565 (compound 17a) is a strong, broad-spectrum anti-epileptic agent (AED) candidate with unique GABAergic function. DSP-0565 shows anti-convulsant activity in various models (scPTZ, MES, 6 Hz and amygdala kindling) with good safety margin .

HY-121602

DSP 4 free base	Adrenergic Receptor	Neurological Disease
DSP 4 Free base is a selective neurotoxin that targets noradrenergic neurons in the locus coeruleus noradrenergic system. DSP 4 Free base possesses the unique ability to cross the blood–brain barrier. DSP 4 Free base cyclizes to form a reactive aziridinium derivative that accumulates in noradrenergic neurons.

HY-139575

Guretolimod DSP-0509	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
Guretolimod (DSP-0509) is a Toll-like receptor 7 (TLR7) agonist .

HY-118759S

DSP Crosslinker-d8	Isotope-Labeled Compounds	Others
DSP Crosslinker-d₈ is the deuterium labeled DSP Crosslinker. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .

HY-RS17087

Dsp Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
Dsp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dsp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dsp Mouse Pre-designed siRNA Set A Dsp Mouse Pre-designed siRNA Set A

HY-RS04026

DSP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DSP Human Pre-designed siRNA Set A contains three designed siRNAs for DSP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DSP Human Pre-designed siRNA Set A DSP Human Pre-designed siRNA Set A

HY-17638

Mizagliflozin 3 Publications Verification DSP-3235 free base; KGA-3235 free base; GSK-1614235 free base	SGLT	Metabolic Disease
Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a K_i of 27 nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic agent that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic constipation .

HY-17638A

Mizagliflozin (sebacate) DSP-3235 (sebacate); KGA-3235 (sebacate); GSK-1614235 (sebacate)	SGLT	Neurological Disease
Mizagliflozin sebacate (DSP-3235 sebacate) is a sodium-glucose cotransporter inhibitor with activity in improving vascular cognitive impairment caused by small vessel disease. Mizagliflozin sebacate improves blood flow and reverses vascular cognitive impairment by inhibiting neuronal SGLT1 activity. Mizagliflozin sebacate also showed the ability to increase the survival rate of IL-1β-treated PC12HS cells. Mizagliflozin sebacate promotes improvements in spatial learning and memory caused by small vessel disease in mouse models .

HY-RS16391

DSPS Human Pre-designed siRNA Set A
DSPS Human Pre-designed siRNA Set A contains three designed siRNAs for DSPS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DSPS Human Pre-designed siRNA Set A DSPS Human Pre-designed siRNA Set A

HY-139575A

Guretolimod hydrochloride DSP-0509 hydrochloride	Toll-like Receptor (TLR)	Others Cancer
Guretolimod hydrochloride is a Toll-like receptor 7 (TLR7) agonist .

HY-156794

Enzomenib DSP-5336	Epigenetic Reader Domain	Cancer
Enzomenib is an inhibitor of the menin protein encoded by the multiple endocrine neoplasia (MEN) gene. Enzomenib can block the binding of the menin protein to mixed lineage leukemia (MLL) fusion proteins and can be used in the study of hematological malignancies .

HY-168631

Antibacterial agent 254	Bacterial	Infection
Antibacterial agent 254 (Compound 2) is a dispersion sensor (DspS) activator that disperses Pseudomonas aeruginosa biofilms. Antibacterial agent 254 can dislodge 7-day P. aeruginosa biofilms at 50 μM. Antibacterial agent 254 also enhances the effects of Ciprofloxacin (HY-B0356) against P. aeruginosa and increases the expression of matrix-degrading enzyme genes pelA, pslG and eddA .

Cat. No.	Compare	Product Name	Species	Source

HY-P72176

	DSP Protein, Human (His-SUMO) 250/210 kDa paraneoplastic pemphigus antigen; DCWHKTA; Desmoplakin DPI DPII; ; Desmoplakin; Desmoplakin I ; Desmoplakin II; DESP_HUMAN; DP; DP I; DP II; DPI; DPII; DSP; KPPS2; PPKS 2; PPKS2	Human	E. coli
	DSP proteins are major components of desmosomes and are critical for the structural integrity of various tissues. In cardiomyocytes, DSP regulates profibrotic gene expression through MAPK14/p38 MAPK activation and increased TGFB1 protein. DSP Protein, Human (His-SUMO) is the recombinant human-derived DSP protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of DSP Protein, Human (His-SUMO) is 223 a.a., with molecular weight of ~42.1 kDa.

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DSP Crosslinker-d8
DSP Crosslinker-d₈ is the deuterium labeled DSP Crosslinker. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82634

	Desmoplakin Antibody (YA2379) Desmoplakin I; Desmoplakin II; DPI; DPII; DSP; KPPS2; PPKS2	WB, ICC/IF, FC	Human, Rat
	Desmoplakin Antibody (YA2379) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2379), targeting Desmoplakin, with a predicted molecular weight of 332 kDa (observed band size: 270 kDa). Desmoplakin Antibody (YA2379) can be used for WB, ICC/IF, FC experiment in human, rat background.

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Dsp Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Dsp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dsp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

DSP Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
DSP Human Pre-designed siRNA Set A contains three designed siRNAs for DSP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DSPS Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
DSPS Human Pre-designed siRNA Set A contains three designed siRNAs for DSPS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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