Search Result

Isoforms Recommended:	ET_A

Results for "

ET-A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin Receptor (1) Apoptosis (8) Autophagy (1) Caspase (1) DNA/RNA Synthesis (1) Drug Metabolite (1) Endothelin Receptor (54) HIV (1) Isotope-Labeled Compounds (2) MARCKS (2) Phosphatase (1) PKA (1) PKC (7) RABV (1) Reverse Transcriptase (1) Tie (1)
By Research Areas:	Cancer (20) Cardiovascular Disease (51) Endocrinology (27) Infection (4) Inflammation/Immunology (8) Metabolic Disease (1) Neurological Disease (4)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-146302

14-3-3η Protein inhibitor 1 2 Publications Verification	Apoptosis	Cancer
14-3-3η Protein inhibitor 1 (Compound C11) is a *14-3-3η* protein inhibitor with a K_D of 35 µM. 14-3-3η Protein inhibitor 1 shows inhibitory activities against several typical human liver cancer cell lines. 14-3-3η Protein inhibitor 1 induces cell apoptosis and G1-S cell cycle arrest with good metabolic stability .

HY-15404

Darusentan Lu-135252	Endothelin Receptor	Cardiovascular Disease Endocrinology
Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) receptor antagonist, which binds with a K_i of 1.4 nM to the ET-A receptor and a K_i of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors . Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a K_i of 13 nM .

HY-130326

RAPTA-C Ru(η6-p-cymene)Cl2(pta)	Apoptosis Caspase	Cardiovascular Disease Cancer
RAPTA-C (Ru(η6-p-cymene)Cl2(pta)) acts as an anti-cancer and anti-angiogenic agent. RAPTA-C exhibits anti-metastatic, anti-angiogenic, and anti-tumoral activities through protein and histone-deoxyribonucleic acid alterations. RAPTA-C exhibits cell growth inhibition by triggering G(2)/M phase arrest in cancer cells. RAPTA-C also enhances the levels of p53 and triggers the mitochondrial Apoptotic pathway, resulting in cytochrome C release and caspase-9 activation. RAPTA-C reduces the growth of tumors with the inhibition of angiogenesis in a ovarian carcinoma model .

HY-112264

ETA antagonist 1	Endothelin Receptor	Cardiovascular Disease
ETA antagonist 1 is a *ETA* selective antagonist with an IC₅₀ of 0.08 μM.

HY-P5885

PKCη pseudosubstrate inhibitor,myristoylated	PKC	Others
PKCη pseudosubstrate inhibitor,myristoylated is cell permeable and can be used to study the mechanism of action of PKCη .

HY-19263

BMS-193884	Endothelin Receptor	Cardiovascular Disease
BMS-193884 is a selective, orally active, and competitive *ET_A* antagonist with 10000-fold greater affinity for the human ET_A receptor (K_i=1.4 nM) than for the ET_B receptor .

HY-117644

L-749329 (Rac)-L-754142	Endothelin Receptor	Cardiovascular Disease
L-749329 ((Rac)-L-754142) is an *ET_A* and ET_B receptor antagonist, with K_is of 0.062 nM and 2.25 nM for ET_A and ET_B respectively. L-749329 inhibits ET-1-stimulated signaling .

HY-114674A

Atrasentan sodium	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Atrasentan sodium is an endothelin receptor antagonist with IC₅₀ of 0.0551 nM for ET_A .

HY-76520

Sitaxsentan IPI 1040; TBC-11251	Endothelin Receptor	Cardiovascular Disease Endocrinology
Sitaxsentan (IPI 1040; TBC-11251) is a selective endothelin A (ETA) receptor antagonist.

HY-135283

ABT-546 A-216546	Endothelin Receptor	Cardiovascular Disease Endocrinology
ABT-546 (A-216546) is a potent, highly selective and active *endothelin ET_A* receptor antagonist with a K_i** of 0.46 nM for [ ¹²⁵I]endothelin-1 binding to cloned human endothelin ET_A. ABT-546 is >25,000-fold more selective for the ET_A receptor than for the ET_B receptor. ABT-546 blocks endothelin-1-induced arachidonic acid release and phosphatidylinositol hydrolysis with IC₅₀ of 0.59 nM and 3 nM, respectively .

HY-15403

Atrasentan 5 Publications Verification ABT-627; (+)-A 127722; A-147627	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Atrasentan (ABT-627) is an endothelin receptor antagonist with IC₅₀ of 0.0551 nM for ET_A .

HY-15403A

Atrasentan hydrochloride 5 Publications Verification ABT-627 hydrochloride; (+)-A 127722 hydrochloride; A-147627 hydrochloride	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Atrasentan hydrochloride (ABT-627 hydrochloride) is a selective endothelin A receptor antagonist with an IC₅₀ of 0.0551 nM for ET_A .

HY-19274

ZD-1611	Endothelin Receptor	Cardiovascular Disease Endocrinology
ZD-1611 is a potent, orally active, selective ETA receptor antagonist, used for the research of ischemic stroke.

HY-15195

Avosentan Ro 67-0565; SPP-301	Endothelin Receptor	Cardiovascular Disease Endocrinology
Avosentan(Ro 67-0565; SPP-301) is a potent, selective endothelin receptor(ETA receptor) antagonist.

HY-118695

IRL-3630	Endothelin Receptor	Inflammation/Immunology
IRL-3630 (Compound 3) is an *ETA/ETB* antagonist (K_i: 1.9 and 1.2 nM) .

HY-101262

SB234551	Endothelin Receptor	Neurological Disease
SB234551 is a selective endothelin *ETA* receptor antagonist. SB234551 can be used in the study of stroke model .

HY-101598

PD-159020	Endothelin Receptor	Cardiovascular Disease Endocrinology
PD-159020 is a non-selective *ETA/ETB* antagonist, with IC₅₀s of 30 and 50 nM for hETA and hETB, respectively.

HY-A0013

Bosentan Maximum Cited Publications 23 Publications Verification	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with K_i of 4.7 nM and 95 nM in human SMC, respectively.

HY-A0013A

Bosentan hydrate Maximum Cited Publications 23 Publications Verification	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Bosentan hydrate is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with K_i of 4.7 nM and 95 nM in human SMC, respectively.

HY-17351

Tezosentan RO 610612	Endothelin Receptor	Cardiovascular Disease Neurological Disease Endocrinology Cancer
Tezosentan (RO 610612) is an endothelin (ET) receptor antagonist, with pA₂s of 9.5, 7.7 for ET_A and ET_B receptors, respectively.

HY-106994A

Nebentan potassium YM598	Endothelin Receptor	Cardiovascular Disease Inflammation/Immunology
Nebentan potassium (YM598) is a potent, selective and orally active non-peptide *endothelin ET_A* receptor** antagonist through the modification of Bosentan (HY-A0013). Nebentan potassium inhibits [ ¹²⁵I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with K_i of 0.697 nM and 569 nM, respectively . YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo .

HY-135500

ACT-373898	Endothelin Receptor	Endocrinology
ACT-373898 is an inactive carboxylic acid metabolite of Macitentan. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist .

HY-15402D

Edonentan hydrate BMS 207940 hydrate	Endothelin Receptor	Cardiovascular Disease
Edonentan (BMS 207940) hydrate is a potent and selective antagonist of the *endothelin A (ETA) receptor, with a K_i* of 10 pM. In rats, Edonentan has superior (100%) oral bioavailbility .

HY-106994

Nebentan YM598 free base	Endothelin Receptor	Cardiovascular Disease Inflammation/Immunology
Nebentan (YM598 free base) is a potent, selective and orally active non-peptide *endothelin ET_A* receptor** antagonist through the modification of Bosentan (HY-A0013). Nebentan inhibits [ ¹²⁵I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with K_i of 0.697 nM and 569 nM, respectively . YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo .

HY-114674

A-127722	Endothelin Receptor	Cardiovascular Disease
A-127722 is A 2, 4-dialarylpyrrolidine-3-carboxylic acid ET_A selective endothelin receptor (ET receptor) antagonist with IC₅₀ value of 0.36 nM .

HY-12307

(-)-Indolactam V 2 Publications Verification Indolactam V	PKC	Cancer
(-)-Indolactam V is a PKC activator, with K_is of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and K_ds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.

HY-115417

Bosentan-d4	Endothelin Receptor	Cardiovascular Disease Endocrinology
Bosentan-d4 is the deuterium labeled Bosentan. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with K_i of 4.7 nM and 95 nM in human SMC, respectively.

HY-P0202

Endothelin 1 (swine, human) 5+ Cited Publications	Endothelin Receptor	Inflammation/Immunology Endocrinology
Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ET_A and ET_B .

HY-14184

Macitentan 5+ Cited Publications ACT-064992	Endothelin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Macitentan (ACT-064992) is an orally active, non-peptide dual *ETA* and ETB (endothelin receptor) antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) .

HY-P0202A

Endothelin 1 (swine, human) (TFA) 5+ Cited Publications	Endothelin Receptor	Cardiovascular Disease
Endothelin 1 (swine, human) (TFA) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ET_A and ET_B .

HY-P10151

PD 156252	Endothelin Receptor	Cardiovascular Disease
PD 156252 is a hexapeptide that is a highly potent endothelin (ET) antagonist. PD 156252 has enhanced binding affinity for rabbit ETA and rat ETB receptor subtypes with IC50 values of 1.0 and 40 nM, respectively.

HY-A0013R

Bosentan (Standard)	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Bosentan (Standard) is the analytical standard of Bosentan. This product is intended for research and analytical applications. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ET_A and ET_B receptors with K_i of 4.7 nM and 95 nM in human SMC, respectively.

HY-17352

Clazosentan Ro 61-1790; VML 588; AXV-034343	Endothelin Receptor	Cardiovascular Disease
Clazosentan (Ro 61-1790) is a selective *endothelin A (ET_A)* receptor** antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction .

HY-A0013AR

Bosentan hydrate (Standard)	Endothelin Receptor	Cardiovascular Disease Endocrinology Cancer
Bosentan (hydrate) (Standard) is the analytical standard of Bosentan (hydrate). This product is intended for research and analytical applications. Bosentan hydrate is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively.

HY-19529

Ro 46-2005	Endothelin Receptor	Cardiovascular Disease Endocrinology
Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM.

HY-102092

FR139317 PD 147953	Endothelin Receptor	Cardiovascular Disease
FR139317 (PD 147953) is a selective ET_A receptor antagonist. FR139317 inhibits cerebral activation by intraventricular endothelin-1 in conscious rats. FR139317 also ameliorates cerebral vasospasm in dogs .

HY-14184A

Macitentan (n-butyl analogue)	Endothelin Receptor	Cardiovascular Disease Endocrinology
Macitentan n-butyl analogue is a n-butyl analogue of Macitentan. Macitentan is an orally active, non-peptide dual endothelin *ETA* and ETB receptor antagonist for the potential treatment of idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

HY-15895

Aprocitentan 2 Publications Verification ACT-132577	Endothelin Receptor	Cardiovascular Disease Endocrinology
Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual *ETA/ETB* antagonist with IC₅₀s of 3.4 nM and 987 nM, and pA₂ valus of 6.7 and 5.5, respectively .

HY-17352A

Clazosentan disodium Ro 61-1790 disodium; VML 588 disodium; AXV-034343 disodium	Endothelin Receptor	Cardiovascular Disease
Clazosentan disodium (Ro 61-1790) is a selective *endothelin A (ET_A)* receptor** antagonist. Clazosentan disodium inhibits ET-1-mediated vasoconstriction. Clazosentan disodium prevents cerebral vasospasm, vasospasm-related cerebral infarction .

HY-10088

Zibotentan ZD4054	Endothelin Receptor Apoptosis	Endocrinology Cancer
Zibotentan (ZD4054) is a potent, selective and orally active *endothelin A (ET_A)* receptor antagonist with a K_i** of 13 nM. Zibotentan has no inhibitory effect on ETB. Zibotentan has anticancer effects and can be used for castration-resistant prostate cancer (CRPC) research .

HY-14184S

Macitentan-d4 ACT-064992-d₄	Isotope-Labeled Compounds Endothelin Receptor Apoptosis	Cardiovascular Disease
Macitentan-d₄ is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH)[1].

HY-19431

Ro 46-8443	Endothelin Receptor	Cardiovascular Disease
Ro 46-8443 is the first non-peptide endothelin ET_B receptor selective antagonist. Ro 46-8443 displays an at least 100-fold selectivity for ET_B (IC₅₀: 34-69 nM) over ET_A receptors (IC₅₀: 6800 nM) .

HY-15402

Edonentan BMS 207940	Endothelin Receptor	Cardiovascular Disease
Edonentan (BMS 207940) is an antagonist for endothelin receptor (ET_A receptor), with a K_i of 10 pM. Edonentan is metabolic stable, exhibits good pharmakokinetic characters in rats. Edonentan regulates the endothelin system, blocks the big Endothelin-induced pressor response in rats model .

HY-114953

BMS-248360	Angiotensin Receptor Endothelin Receptor	Cardiovascular Disease
BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and *endothelin A (ET_A)* receptor, with K_i**s of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 displays hypertensive effects .

HY-15895S

Aprocitentan-d4 ACT-132577 d₄	Isotope-Labeled Compounds Endothelin Receptor	Cardiovascular Disease Endocrinology
Aprocitentan-d₄ is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively[1].

HY-14184R

Macitentan (Standard)	Endothelin Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Macitentan (Standard) is the analytical standard of Macitentan. This product is intended for research and analytical applications. Macitentan (ACT-064992) is an orally active, non-peptide dual *ETA* and ETB (endothelin receptor) antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) .

HY-10343

Sotrastaurin 15+ Cited Publications AEB071	MARCKS PKC	Inflammation/Immunology Cancer
Sotrastaurin (AEB071) is a potent and orally-active pan-PKC inhibitor, with K_is of 0.22 nM, 0.64 nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively .

HY-15894A

BQ-788 5+ Cited Publications	Endothelin Receptor	Cardiovascular Disease Endocrinology
BQ-788 is a potent, selective ETB receptor antagonist with IC₅₀ of 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC cells with IC₅₀ of 1300 nM .

HY-103460

IRL 2500	Endothelin Receptor	Cardiovascular Disease
IRL 2500 is a potent Endothelin receptor antagonist. IRL 2500 shows IC₅₀ values of 1.3 and 94 nM for ET_B and ET_A receptors, respectively. IRL 2500 inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo .

HY-P1112

Sarafotoxin S6a	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an *ET_A/ET_B* selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC₅₀ value of 7.5 nM .

Cat. No.	Product Name

HY-L006

GPCR/G Protein Compound Library

2,528 compounds

GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. GPCRs play an important role in the human body, and increased understanding of these receptors has greatly affected modern medicine. In fact, researchers estimate that between one-third to one-half of all approved drugs act by binding to GPCRs. GPCRs are a large group of drug targets in drug discovery.

MCE provides a unique collection of 2,528 small molecules targeting GPCRs that can be used in the screening for various GPCRs-related research and drug development projects.

Cat. No.	Product Name	Target	Research Area

HY-P0202

Endothelin 1 (swine, human) Maximum Cited Publications 6 Publications Verification	Endothelin Receptor	Inflammation/Immunology Endocrinology
Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ET_A and ET_B .

HY-P0202A

Endothelin 1 (swine, human) (TFA) Maximum Cited Publications 6 Publications Verification	Endothelin Receptor	Cardiovascular Disease
Endothelin 1 (swine, human) (TFA) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ET_A and ET_B .

HY-12378

BQ-123 2 Publications Verification	Endothelin Receptor	Cardiovascular Disease
BQ-123 is a potent and selective *endothelin A (ETA) receptor* antagonist with an IC₅₀ of 7.3 nM and a K_i of 25 nM. BQ-123 inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells and lowers blood pressure in different rat models of hypertension .

HY-P5885

PKCη pseudosubstrate inhibitor,myristoylated	PKC	Others
PKCη pseudosubstrate inhibitor,myristoylated is cell permeable and can be used to study the mechanism of action of PKCη .

HY-105183

PD 145065	Peptides	Others
PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC₅₀ value of 4 nM for the ET_A receptor for rabbit renal artery vascular smooth muscle cells .

HY-P10151

PD 156252	Endothelin Receptor	Cardiovascular Disease
PD 156252 is a hexapeptide that is a highly potent endothelin (ET) antagonist. PD 156252 has enhanced binding affinity for rabbit ETA and rat ETB receptor subtypes with IC50 values of 1.0 and 40 nM, respectively.

HY-P1112

Sarafotoxin S6a	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an *ET_A/ET_B* selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC₅₀ value of 7.5 nM .

HY-P1112A

Sarafotoxin S6a TFA	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Sarafotoxin S6a TFA , a sarafotoxin analogue, is a endothelin receptor agonist and has an *ET_A/ET_B* selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a TFA elicits the pig coronary artery with an EC₅₀ value of 7.5 nM .

HY-P2496

Endothelin 1 (swine, human), Alexa Fluor 488-labeled	Endothelin Receptor	Cardiovascular Disease
Endothelin 1 (swine, human), Alexa Fluor 488-labeled is a synthetic Endothelin 1 peptide labled with Alexa Fluor 488. Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ET_A and ET_B .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18980

Rottlerin 5+ Cited Publications Mallotoxin; NSC 56346; NSC 94525	Structural Classification Chalcones Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Euphorbiaceae Plants Disease Research Fields Mallotus philippensis Cancer	PKC Autophagy Apoptosis HIV RABV
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC₅₀ values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation . Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection .

HY-121197

Balanol Ophiocordin; Azepinostatin	Structural Classification Natural Products Microorganisms Source classification	MARCKS PKA PKC
Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes α, β-I, β-II, γ, δ, ε, η (IC₅₀s=4-9 nM) and ζ (IC₅₀=150 nM). Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS). Balanol can be isolated from the fungus Verticillium balanoides .

Species:	Human (5) Mouse (3) Cynomolgus (1)
Tag:	His (5) Tag Free (2) GST (2)
Source:	HEK293 (2) P. pastoris (2) Sf9 insect cells (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P71730

	EDNRA Protein, Human (P.pastoris, His) Ednra; ET A; ET-A; ETA; ETA R; ETA-R; ETAR; ETRA; G protein coupled receptor; hET AR; hET-AR; MFDA	Human	P. pastoris
	EDNRA Protein, a receptor for endothelin-1, activates a phosphatidylinositol-calcium second messenger system through association with G proteins. Its binding affinities follow the order: ET1 > ET2 >> ET3. Additionally, EDNRA interacts with HDAC7 and KAT5. EDNRA Protein, Human (P.pastoris, His) is the recombinant human-derived EDNRA protein, expressed by P. pastoris , with N-His labeled tag. The total length of EDNRA Protein, Human (P.pastoris, His) is 60 a.a., with molecular weight of ~62 kDa.

HY-P71682

	*14-3-3 eta* Protein, Human (GST)** 14-3-3 protein ETa; Brain protein 14-3-3; ETa isoform; HGNC:12853; Protein AS1; YWHA 1; YWHA1; Ywhah	Human	E. coli
	YWHAH proteins are adapter proteins in multiple signaling pathways that recognize phosphoserine or phosphothreonine motifs and regulate chaperone activity upon binding. It negatively regulates PDPK1 kinase activity and interacts with nuclear hormone receptors (AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP, THRA) and cofactors. 14-3-3 eta Protein, Human (GST) is the recombinant human-derived YWHAH protein, expressed by E. coli , with N-GST labeled tag.

HY-P74200

	DEP-1/CD148 Protein, Human (341a.a, His) Receptor-type tyrosine-protein phosphatase ETa; R-PTP-ETa; DEP-1; CD148; PTPRJ	Human	E. coli
	DEP-1/CD148 protein is a tyrosine phosphatase that affects multiple targets such as CTNND1, FLT3, PDGFRB, and EGFR, thereby affecting cellular processes such as adhesion, migration, proliferation, and differentiation. DEP-1/CD148 is critical in vascular development, regulating macrophage adhesion, platelet activation, and thrombosis, while negatively regulating cell proliferation and PDGF-stimulated migration. DEP-1/CD148 Protein, Human (341a.a, His) is the recombinant human-derived DEP-1/CD148 protein, expressed by E. coli , with N-His labeled tag.

HY-P72546

	IL-36 beta/IL-1F8 Protein, Mouse (153a.a) Interleukin-36 bETa; FIL1 ETa; IL-1 ETa; IL-1F8; IL-1H2; IL36B	Mouse	E. coli
	IL-36 beta (IL-1F8), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 beta mediates inflammatory response. L-36 beta binds to IL-36R and recruits the co-receptor IL-1RacP, and thereby activating NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases. IL-36 beta/IL-1F8 Protein, Mouse (153a.a) is a recombinant mouse IL-36 beta (S31-K183) without any tag, which is produced in E. coli.

HY-P71786

	Osteopontin/OPN Protein, Mouse (P.pastoris, His) 1 Publications Verification Spp1; ETa-1; Op; Spp-1; Osteopontin; 2AR; Minopontin; SecrETed phosphoprotein 1; SPP-1	Mouse	P. pastoris
	Osteopontin/OPN Protein, a crucial non-collagenous bone protein, binds strongly to hydroxyapatite, integral to the mineralized matrix.It likely plays a vital role in mediating cell-extracellular matrix interactions.Moreover, as a cytokine, OPN efficiently induces interferon-gamma and interleukin-12 production while inhibiting interleukin-10, pivotal in promoting type I immunity.Osteopontin/OPN Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Osteopontin/OPN protein, expressed by P.pastoris , with N-6*His labeled tag.

HY-P78358

	Osteopontin/OPN Protein, Mouse (HEK293, His) 1 Publications Verification Osteopontin; Bone sialoprotein 1; Nephropontin; SPP-1; BNSP; OPN; SPP1; Uropontin; BSP-1; ETA-1; BSPI	Mouse	HEK293
	Osteopontin/OPN Protein, a crucial non-collagenous bone protein, binds strongly to hydroxyapatite, integral to the mineralized matrix.It likely plays a vital role in mediating cell-extracellular matrix interactions.Moreover, as a cytokine, OPN efficiently induces interferon-gamma and interleukin-12 production while inhibiting interleukin-10, pivotal in promoting type I immunity.Osteopontin/OPN Protein, Mouse (HEK293, His) is the recombinant mouse-derived Osteopontin/OPN protein, expressed by HEK293 , with C-His labeled tag.

HY-P701071

	Osteopontin/OPN Protein, Cynomolgus (HEK293, His) SecrETed phosphoprotein 1; Osteopontin; Bone sialoprotein 1; Nephropontin; SPP-1; BNSP; OPN; SPP1; Uropontin; BSP-1; ETA-1; BSPI	Cynomolgus	HEK293
	Osteopontin/OPN Protein, a vital member of the osteopontin family, plays a pivotal role in cell adhesion, immune response modulation, and tissue mineralization. Sharing conserved features within the family, Osteopontin's versatile nature contributes to both homeostatic and pathological conditions. Its study provides valuable insights into the broader understanding of the osteopontin family's roles in biological functions, offering potential therapeutic avenues and further exploration of intricate interactions within cellular pathways. Osteopontin/OPN Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Osteopontin/OPN protein, expressed by HEK293, with C-His labeled tag. The total length of Osteopontin/OPN Protein, Cynomolgus (HEK293, His) is 284 a.a., with molecular weight of 45-55 kDa.

HY-P702643

	PRKCH Protein, Human (sf9, GST) PKCL; PKC-L; PRKCL; nPKC-ETa; protein kinase C ETa type	Human	Sf9 insect cells
	PRKCH Protein, Human (sf9, GST) is the recombinant human-derived PRKCH, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P72545

	IL-36 beta/IL-1F8 Protein, Human (157a.a) Interleukin-36 bETa; FIL1 ETa; IL-1 ETa; IL-1F8; IL-1H2; IL36B	Human	E. coli
	IL-36 beta (IL-1F8), a subform of IL-36 family, belongs to IL-1 superfamily. IL-36 beta mediates inflammatory response. L-36 beta binds to IL-36R and recruits the co-receptor IL-1RacP, and thereby activating NF-κB and MAPK signaling pathways, but the activation requires N-terminal cleavage by neutrophil granule-derived proteases. IL-36 beta/IL-1F8 Protein, Human is a recombinant human IL-36 beta without any tag, which is produced in E. coli.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-14184S

Macitentan-d4
Macitentan-d₄ is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH)[1].

HY-15895S

Aprocitentan-d4
Aprocitentan-d₄ is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively[1].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80869

	*PKC eta* Antibody** nPKC ETa; PKC h; PKC L; PKCh; PKCL; Prkch; PRKCL; Protein kinase C ETa	WB, IP	Human, Mouse, Rat
	PKC eta Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 78 kDa, targeting to PKC eta. It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80525

	*14-3-3 eta* Antibody (YA838)** 14-3-3 protein ETa; 1433F_HUMAN; Brain protein 14-3-3; ETa isoform; HGNC:12853; Protein AS1; Tyrosine 3/tryptophan 5 monooxygenase activation protein ETa polypeptide; YWHA 1; YWHA1; Ywhah.	WB	Human, Mouse, Rat
	14-3-3 eta Antibody (YA838) is a non-conjugated and Mouse origined monoclonal antibody about 28 kDa, targeting to 14-3-3 eta (5F2). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.