2. GPCR/G Protein
  3. Endothelin Receptor
  4. Sarafotoxin S6a

Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC50 value of 7.5 nM.

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Custom Peptide Synthesis

Sarafotoxin S6a Chemical Structure

Sarafotoxin S6a Chemical Structure

CAS No. : 126738-34-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Sarafotoxin S6a:

Sarafotoxin S6a Related Antibodies

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ETA ETB

  • Biological Activity

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Description

Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC50 value of 7.5 nM[1].

IC50 & Target[1]

ETB

 

ETA

 

In Vitro

Sarafotoxin S6a is a rather weak agonist effect in guinea-pig aorta, the eliting concentration (EC50) is 150 nM in guinea-pig aorta[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sarafotoxin S6a Related Antibodies
Molecular Weight

2514.85

Formula

C105H156N28O34S5
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp (Disulfide bridge:Cys1-Cys15;Cys3-Cys11)
Sequence Shortening

CSCKDMTDKECLNFCHQDVIW (Disulfide bridge:Cys1-Cys15;Cys3-Cys11)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (19.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3976 mL 1.9882 mL 3.9764 mL
5 mM 0.0795 mL 0.3976 mL 0.7953 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

  • Protocol 1

    S6a is dissolved in 0.1% aqueous acetic acid and diluted in 0.9% NaCl[1].

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3976 mL 1.9882 mL 3.9764 mL 9.9410 mL
5 mM 0.0795 mL 0.3976 mL 0.7953 mL 1.9882 mL
10 mM 0.0398 mL 0.1988 mL 0.3976 mL 0.9941 mL
15 mM 0.0265 mL 0.1325 mL 0.2651 mL 0.6627 mL
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Sarafotoxin S6a Related Classifications

Keywords:

Sarafotoxin S6a126738-34-9Endothelin Receptorguinea-pigaortaendothelin receptorcoronary arteryEndothelin-3Inhibitorinhibitorinhibit

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