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Results for "

FUT8

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Autophagy (1) EGFR (1) FGFR (1) Glucosylceramide Synthase (GCS) (1) Interleukin Related (1) mTOR (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (4) Infection (1) Inflammation/Immunology (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155747

FDW028	Autophagy Akt mTOR	Cancer
FDW028 a potent and highly selective FUT8 inhibitor. FUT8 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the chaperone-mediated autophagy (CMA) pathway. FDW028 can be used for metastatic colorectal cancer (mCRC) research .

HY-E70157

Fucosyltransferase 8 EC:2.4.1.68; FUT8; α1-6FucT	Glucosylceramide Synthase (GCS)	Infection
Fucosyltransferase 8 (EC:2.4.1.68; FUT8; α1-6FucT) is a glycosyl transferase and catalyzes the transfer of a fucose residue from GDP-fucose to the innermost N-acetylglucosamine residue of N-glycans .

HY-RS05159

FUT8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FUT8 Human Pre-designed siRNA Set A contains three designed siRNAs for FUT8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FUT8 Human Pre-designed siRNA Set A FUT8 Human Pre-designed siRNA Set A

HY-P99010A

*Bemarituzumab (FUT8-KO)*	Interleukin Related FGFR	Cancer
Bemarituzumab (FUT8-KO) is a FUT8 gene missing, humanized immunoglobulin G1 monoclonal antibody against FGFR2b . Bemarituzumab (FUT8-KO) lacks a core fucose in the polysaccharide portion of the Fc domain of the antibody, and results in a high affinity to human FcγRIIIa .

HY-P9977A

*Amivantamab (FUT8-KO)*	EGFR	Cancer
Amivantamab (FUT8-KO) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab (FUT8-KO) inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .

Cat. No.	Product Name	Type

HY-E70157

Fucosyltransferase 8 EC:2.4.1.68; FUT8; α1-6FucT	Enzyme Substrates
Fucosyltransferase 8 (EC:2.4.1.68; FUT8; α1-6FucT) is a glycosyl transferase and catalyzes the transfer of a fucose residue from GDP-fucose to the innermost N-acetylglucosamine residue of N-glycans .

Cat. No.	Product Name	Target	Research Area

HY-P99010A

*Bemarituzumab (FUT8-KO)*	Interleukin Related FGFR	Cancer
Bemarituzumab (FUT8-KO) is a FUT8 gene missing, humanized immunoglobulin G1 monoclonal antibody against FGFR2b . Bemarituzumab (FUT8-KO) lacks a core fucose in the polysaccharide portion of the Fc domain of the antibody, and results in a high affinity to human FcγRIIIa .

HY-P99653A

*Ianalumab (FUT8-KO)*	Inhibitory Antibodies	Cancer
Ianalumab (FUT8-KO) is a human, decarboxylated antibody against BAFF-R. Ianalumab (FUT8-KO) can block the interaction between BAFF and BAFF-R and antagonize the apoptosis protection mediated by BAFF. Ianalumab (FUT8-KO) exerts antibody-dependent cytotoxic (ADCC), depending on effector cell activation mediated by immune receptor tyrosine activation motif (ITAM) .

HY-P9977A

*Amivantamab (FUT8-KO)*	EGFR	Cancer
Amivantamab (FUT8-KO) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab (FUT8-KO) inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .

HY-P99113A

*Inebilizumab (FUT8-KO)*	Inhibitory Antibodies	Inflammation/Immunology
Inebilizumab (FUT8-KO) is Inebilizumab with the fucosyltransferase 8 gene (FUT8) knocked out. Inebilizumab (HY-P99113) is a monoclonal antibody (mAb) targeting CD19, exhibiting enhanced antibody-dependent cellular cytotoxicity (ADCC) against B cells. Inebilizumab can be used for research on multiple sclerosis and neuromyelitis optica .

Species:	Human (1)
Tag:	His (2)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P75181

	FUT8 Protein, Human (sf9, His) Alpha-(1,6)-fucosyltransferase; Alpha1-6FucT; FUT8; Fucosyltransferase 8	Human	Sf9 insect cells
	The FUT8 protein acts as a catalyst during glycosylation, specifically adding fucose in an α1-6 linkage to the first GlcNAc residue located near the N-glycan peptide chain. This enzymatic activity plays a crucial role in glycoprotein modification, contributing to the structural diversity and functional properties of N-glycans. FUT8 Protein, Human (sf9, His) is the recombinant human-derived FUT8 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P75783

	FUT8 Protein, Hamster (sf9, His) Alpha-(1,6)-fucosyltransferase; Alpha1-6FucT; FUT8; Fucosyltransferase 8	Others	Sf9 insect cells
	FUT8 protein catalyzes the addition of fucose to the initial GlcNAc residue in N-glycans. FUT8 Protein, Hamster (sf9, His) is the recombinant FUT8 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of FUT8 Protein, Hamster (sf9, His) is 508 a.a., with molecular weight of ~55 kDa.

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FUT8 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
FUT8 Human Pre-designed siRNA Set A contains three designed siRNAs for FUT8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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