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FXN

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ferroptosis (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

*FXn*	Others	Others
FXn is a hapten that can be used for the generation of mAbs. FXh is activated by incubation with N, N′-disuccinimidyl carbonate, and Et3N in acetonitrile at 0 °C. FXn is covalently linked to the protein via N-hydroxy succinimidyl ester .

FXN Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FXN Human Pre-designed siRNA Set A contains three designed siRNAs for FXN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FXN Human Pre-designed siRNA Set A FXN Human Pre-designed siRNA Set A

1(R)-(Trifluoromethyl)oleyl alcohol	Ferroptosis	Neurological Disease
1(R)-(Trifluoromethyl)oleyl alcohol (compound (R)-24) is a trifluoromethyl alcohol derivative of Oleic acid (HY-N1446) with activity in multiple models of Friedreich ataxia (FRDA). 1(R)-(Trifluoromethyl)oleyl alcohol inhibits ferroptosis induced by Erastin (HY-15763) and decreases lipid peroxidation in NBT human myoblasts with frataxin (FXN) siRNA knockdown. 1(R)-(Trifluoromethyl)oleyl alcohol at 40 μM increases survival to 95% in a model of FRDA where a significant percentage of cell death is caused by FAC (HY-B1645) and BSO (HY-106376) .

Cat. No.	Compare	Product Name	Species	Source

	*Frataxin/FXN* Protein, Cynomolgus (His)** FXN; FRDA1; QnpA-13971; Frataxin; mitochondrial; FXN; EC 1.16.3.1) [Cleaved into: Frataxin intermediate form; Frataxin mature form]	Cynomolgus	E. coli
	Frataxin (FXN) protein activates persulfide transfer, which is critical for [2Fe-2S] cluster assembly. It accelerates sulfur transfer from NFS1 persulfide to ISCU and small thiols, resulting in oversulfide and sulfide release. Frataxin/FXN Protein, Cynomolgus (His) is the recombinant cynomolgus-derived Frataxin/FXN protein, expressed by E. coli , with N-6*His labeled tag. The total length of Frataxin/FXN Protein, Cynomolgus (His) is 130 a.a., with molecular weight (affected by relative charge) of ~22 KDa.

	*Frataxin/FXN* Protein, Human (His, Myc)** CyaY; FRDA; X25	Human	E. coli
	Frataxin/FXN protein activates the core iron-sulfur cluster assembly complex and accelerates sulfur transfer for [2Fe-2S] cluster assembly. It plays a key role in the de novo synthesis of clusters, delivering persulfide to the ISCU. Frataxin/FXN Protein, Human (His, Myc) is the recombinant human-derived Frataxin/FXN protein, expressed by E. coli , with C-Myc, N-10*His labeled tag.

	FXN Protein, Mouse (P.pastoris, His) FXN; FrdaFrataxin; mitochondrial; FXN	Mouse	P. pastoris
	FXN protein is a key activator in the core iron-sulfur cluster (ISC) assembly complex, accelerating persulfide transfer to ISCU and [2Fe-2S] cluster assembly. It promotes sulfur transfer, leading to oversulfidation and sulfide release. FXN Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived FXN protein, expressed by P. pastoris , with N-His labeled tag.

	FXN Protein, Rat Frataxin; mitochondrial; FXN; EC 1.16.3.1; Frataxin intermediate form; Frataxin mature form	Rat	E. coli
	FXN protein activates persulfide transfer in the ISC assembly complex, promoting sulfur transfer and leading to persulfide and sulfide release. It binds ferrous ions, initiates [2Fe-2S] cluster synthesis, and transfers it to chaperone proteins. FXN Protein, Rat is the recombinant rat-derived FXN protein, expressed by E. coli , with tag free. The total length of FXN Protein, Rat is 168 a.a., with molecular weight of ~18.6 kDa.

	FXN Protein, Mouse (His) FrdaFrataxin; mitochondrial; FXN; EC 1.16.3.1; Frataxin intermediate form; Frataxin mature form	Mouse	E. coli
	FXN protein is a key activator in the core iron-sulfur cluster (ISC) assembly complex, accelerating persulfide transfer to ISCU and [2Fe-2S] cluster assembly. It promotes sulfur transfer, leading to oversulfidation and sulfide release. FXN Protein, Mouse (His) is the recombinant mouse-derived FXN protein, expressed by E. coli , with N-6*His labeled tag. The total length of FXN Protein, Mouse (His) is 130 a.a., with molecular weight of ~19.9 kDa.

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FXN Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
FXN Human Pre-designed siRNA Set A contains three designed siRNAs for FXN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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