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Factor VIIa

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Factor VIIa (3) Factor Xa (2)
By Research Areas:	Cardiovascular Disease (1)
Oligonucleotides:	Aptamers (2)

4

Inhibitors & Agonists

2

Peptides

3

Recombinant Proteins

2

Oligonucleotides

Targets Recommended: Factor VIIa

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

BMS-593214	Factor VIIa	Cardiovascular Disease
BMS-593214 is an active site-directed **factor (F) VIIa** inhibitor. BMS-593214 shows antithrombotic and antihaemostatic properties. BMS-593214 is a direct competitive inhibitor of human FVIIa and a non-competitive inhibitor of Viia-activated substrate FX. BMS-593214 prevents electroinduced carotid artery thrombosis (AT) and wire induced vena cava thrombosis (VT) .

ARC19499 sodium BAX499 sodium	Factor Xa Factor VIIa	Others
ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

Human Factor VIIa	Factor VIIa	Others
Human Factor VIIa is a vitamin K-dependent serine protease that is involved in the blood coagulation process. Human Factor VIIa activates Factor X, which causes the conversion of prothrombin to thrombin and the conversion of fibrinogen to fibrin, leading to the formation of blood clots. Human Factor VIIa exhibits the potential to ameliorate Hemophilia .

ARC19499 BAX499	Factor Xa	Others
ARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

Cat. No.	Product Name	Target	Research Area

Factor VIIa substrate	Peptides	Others
Factor VIIa substrate is a colorimetric substrate for Factor VIIa, that can be measured by absorbance at 405 nm .

E-76	Peptides	Others
E-76 is a peptide with anticoagulant activity. E-76 inhibits blood coagulation by specifically binding to exogenous coagulation factor VIIa (FVIIa). E-76 can be used to study blood coagulation-related diseases .

Species:	Human (1) Mouse (2)
Tag:	His (3) Myc (2)
Source:	HEK293 (2) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

	PLA2G7 Protein, Human (HEK293, His) Platelet-Activating Factor Acetylhydrolase; PAF Acetylhydrolase; 1-Alkyl-2-Acetylglycerophosphocholine Esterase; 2-Acetyl-1-Alkylglycerophosphocholine Esterase; Group-VIIa Phospholipase A2; gVIIa-PLA2; LDL-Associated Phospholipase A2; LDL-PLA(2); PAF 2-Acylhydrol	Human	HEK293
	PLA2G7 Protein is a lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress responses. It is also a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. PLA2G7 can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups. PLA2G7 Protein, Human (HEK293, His) is the recombinant human-derived PLA2G7 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PLA2G7 Protein, Human (HEK293, His) is 420 a.a., with molecular weight of ~57 kDa.

	PLA2G7 Protein, Mouse (Baculovirus, N-His, C-Myc) PLA2G7; phospholipase A2, group VII (platelet-activating Factor acetylhydrolase, plasma); platelet-activating Factor acetylhydrolase; LDL PLA2; PAFAH; LDL-PLA(2); gVIIa-PLA2; PAF 2-acylhydrolase; PAF acetylhydrolase; group-VIIa phospholipase A2; LDL-associated phospholipase A2; lipoprotein-associated phospholipase A2; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; PAFAD; LP-PLA2; LDL-PLA2	Mouse	Sf9 insect cells
	The PLA2G7 protein is a lipoprotein-associated calcium-independent phospholipase A2 that plays a key role in phospholipid catabolism during inflammation and oxidative stress responses.It acts at the lipid-water interface and hydrolyzes the ester bond of the fatty acyl group at the sn-2 position, with particular preference for short-chain fatty acyl groups.PLA2G7 Protein, Mouse (Baculovirus, N-His, C-Myc) is the recombinant mouse-derived PLA2G7 protein, expressed by Sf9 insect cells , with C-Myc, N-10*His labeled tag.

	PLA2G7 Protein, Mouse (HEK293, N-His, C-Myc) PLA2G7; phospholipase A2, group VII (platelet-activating Factor acetylhydrolase, plasma); platelet-activating Factor acetylhydrolase; LDL PLA2; PAFAH; LDL-PLA(2); gVIIa-PLA2; PAF 2-acylhydrolase; PAF acetylhydrolase; group-VIIa phospholipase A2; LDL-associated phospholipase A2; lipoprotein-associated phospholipase A2; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; PAFAD; LP-PLA2; LDL-PLA2	Mouse	HEK293
	The PLA2G7 protein is a lipoprotein-associated calcium-independent phospholipase A2 that plays a key role in phospholipid catabolism during inflammation and oxidative stress responses.It acts at the lipid-water interface and hydrolyzes the ester bond of the fatty acyl group at the sn-2 position, with particular preference for short-chain fatty acyl groups.PLA2G7 Protein, Mouse (HEK293, N-His, C-Myc) is the recombinant mouse-derived PLA2G7 protein, expressed by HEK293 , with C-Myc, N-10*His labeled tag.

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Cat. No.	Product Name		Classification

ARC19499 sodium BAX499 sodium		Aptamers
ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

ARC19499 BAX499		Aptamers
ARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

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