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Results for "

Factor XIIa

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

2

Recombinant Proteins

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-E70393E
    Human Factor XIIa Beta

    		Angiotensin Receptor Others
    Human Factor XIIa Beta is the active fragment of coagulation factor XII, that participates in the intrinsic pathway of coagulation, and leads to the formation of blood clots. Human Factor XIIa Beta also participates in the kinin-generating pathway, which leads to the release of bradykinin (vasodilator). Human Factor XIIa Beta stimulates the release of catecholamines, and mediates its cardiovascular effects through a noncholinergic angiotensin-converting enzyme (ACE)-regulated mechanism .
    Human Factor XIIa Beta
  • HY-E70393D
    Human Factor Alpha XIIa

    		Others Others
    Human Factor Alpha XIIa is a blood coagulation protease, which increases the clotting potential. Human Factor Alpha XIIa exhibits a fibrinolysis protein homologous heavy chain, indicating its function in fibrinolysis .
    Human Factor Alpha XIIa
  • HY-149396
    FXIIa-IN-1

    		Thrombin Cardiovascular Disease
    XIIa-IN-1-IN-3 (Compound 22) is a Factor XIIa inhibitor (Ki app: 97.8 nM). XIIa-IN-1-IN-3 can be used for research of thrombosis .
    FXIIa-IN-1
  • HY-149397
    FXIIa-IN-2

    		Thrombin Cardiovascular Disease
    FXIIa-IN-1-IN-2 (Compound 21) is a Factor XIIa inhibitor (Ki app: 62.2 nM). FXIIa-IN-1-IN-2 can be used for research of thrombosis .
    FXIIa-IN-2
  • HY-E70545
    Human Factor XI

    		Factor XI Cardiovascular Disease
    Human Factor XI can be activated by factor XIIa to factor XIa. Human Factor XI can be used for the study of antithrombotic .
    Human Factor XI
  • HY-E70546
    Human Factor XII

    		Biochemical Assay Reagents Cardiovascular Disease
    Human Factor XII is a naturally occurring coagulation factor in human plasma. Human Factor XII is a single-chain polypeptide that, upon activation (primarily by kallikrein), is converted to factor α XIIa .
    Human Factor XII
  • HY-163347
    FXIIa-IN-3

    		Factor Xa Cardiovascular Disease
    FXIIa-IN-3 (Compound 8) is a potent and selective Factor XIIa (FXIIa) inhibitor, with an IC50 of 0.045 μM. FXIIa-IN-3 also exhibits a substantial margin of selectivity against related serine proteases, including FXIa, FXa, and FIXa. FXIIa-IN-3 can be used for the research of thromboembolic diseases .
    FXIIa-IN-3
  • HY-162646
    FXIIa-IN-5

    		Thrombin Cardiovascular Disease
    FXIIa-IN-5 (Compound 4J) is an orally active, selective inhibitor for factor XIIa (FXIIa), with IC50 of 21 nM. FXIIa-IN-5 inhibits the intrinsic coagulation pathways, and exhibits anti-inflammatory and antithrombotic activity in Carrageenan (HY-125474)-induced mice thrombosis models. FXIIa-IN-5 exhibits moderate pharmacokinetic characteristics and slightly toxicity (at 100 mg/kg) .
    FXIIa-IN-5

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