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Results for "

Fingolimod

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Isotope-Labeled Compounds (2) LPL Receptor (10) PAK (6) Phosphatase (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (10) Neurological Disease (2)

Inhibitors & Agonists

Screening Libraries

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-11063

*Fingolimod* Maximum Cited Publications 47 Publications Verification FTY720 free base	LPL Receptor PAK	Inflammation/Immunology Cancer
Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC₅₀ of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant .

HY-11063R

Fingolimod (Standard)	LPL Receptor PAK	Inflammation/Immunology Cancer
Fingolimod (Standard) is the analytical standard of Fingolimod. This product is intended for research and analytical applications. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC₅₀ of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant .

HY-15381

Fingolimod phosphate 1 Publications Verification FTY720 phosphate	LPL Receptor	Infection Neurological Disease Inflammation/Immunology
Fingolimod phosphate (FTY720 phosphate) is an orally active sphingosine 1-phosphate (S1P) receptor agonist. Fingolimod phosphate can promote the neuroprotective effects of microglia. Fingolimod phosphate can be used for the research of multiple sclerosis and neurologic diseases .

HY-12005

Fingolimod hydrochloride Maximum Cited Publications 47 Publications Verification FTY720	LPL Receptor PAK	Inflammation/Immunology Cancer
Fingolimod (FTY720) hydrochloride is a sphingosine 1-phosphate (S1P) antagonist with IC₅₀ of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride is also a pak1 activator and immunosuppressant .

HY-11063S1

Fingolimod-d4 hydrochloride FTY720-d₄	LPL Receptor PAK	Inflammation/Immunology Cancer
Fingolimod-d₄ (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant[1].

HY-11063S

Fingolimod-d4 FTY720 free based-d₄	LPL Receptor PAK	Inflammation/Immunology Cancer
Fingolimod-d₄ is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant[1].

HY-12005R

Fingolimod (hydrochloride) (Standard) FTY720 (Standard)	LPL Receptor PAK	Inflammation/Immunology Cancer
Fingolimod (hydrochloride) (Standard) is the analytical standard of Fingolimod (hydrochloride). This product is intended for research and analytical applications. Fingolimod hydrochloride (FTY720), an analog of sphingosine, is a potent sphingosine 1-phosphate (S1P) receptors modulator. Fingolimod hydrochloride is phosphorylated by sphingosine kinases, particularly by SK2, and then binds S1PR1, 3, 4, and 5. Fingolimod hydrochloride induces the internalization of S1P1, and consequently, inhibits S1P activity. Fingolimod hydrochloride also is a pak1 activator .

HY-143959S

Fingolimod Mono-lactate-d4 hydrochloride	Isotope-Labeled Compounds	Others
Fingolimod Mono-lactate-d₄ (hydrochloride) is the deuterium labeled Fingolimod Mono-lactate hydrochloride[1].

HY-15381S

Fingolimod phosphate-d4 FTY720 phosphate-d₄	LPL Receptor Isotope-Labeled Compounds	Others
Fingolimod phosphate-d₄ is deuterium labeled FTY720 Phosphate.

HY-135284

FTY720-Mitoxy	Phosphatase	Neurological Disease Inflammation/Immunology
FTY720-Mitoxy is a fingolimod hydrochloride (HY-12005) derivative with neuroprotective and PP2A activating activities. FTY720-Mitoxy has the property of targeting mitochondria. In addition, FTY720-Mitoxy protects neurons by reducing inflammatory responses and is used in the study of neurodegenerative diseases such as Parkinson's disease .

HY-16734

Amiselimod MT-1303	LPL Receptor	Cardiovascular Disease Inflammation/Immunology
Amiselimod (MT-1303) is converted to its active metabolite Amiselimod phosphate by sphingosine kinases in vivo. Amiselimod is an orally active and high selectivity sphingosine 1-phosphate receptor-1 (S1P1) agonist, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators. Amiselimod inhibits chronic colitis via inhibiting infiltration of colitogenic Th1 and Th17 cells into the colon. Amiselimod inhibits lupus nephritis by reducing the infiltration of autoreactive T cells into the kidneys. Amiselimodis promising for research of autoimmune diseases .

HY-16734A

Amiselimod hydrochloride MT-1303 hydrochloride	LPL Receptor	Cardiovascular Disease Inflammation/Immunology
Amiselimod (MT-1303) hydrochloride is converted to its active metabolite Amiselimod phosphate by sphingosine kinases in vivo. Amiselimod hydrochloride is an orally active and high selectivity sphingosine 1-phosphate receptor-1 (S1P1) agonist, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators. Amiselimod hydrochloride inhibits chronic colitis via inhibiting infiltration of colitogenic Th1 and Th17 cells into the colon. Amiselimod hydrochloride inhibits lupus nephritis by reducing the infiltration of autoreactive T cells into the kidneys. Amiselimod hydrochloride is promising for research of autoimmune diseases .

Cat. No.	Product Name

HY-L206

High-Throughput Natural Product Library	4,664 compounds
Natural products (NPs) are a class of widely bioactive compounds that have been shown to have a variety of uses, including pharmaceutical, agricultural, industrial and other fields. Historically, natural products have played a key role in drug discovery, particularly for cancer and infectious diseases, but also in other therapeutic areas, including cardiovascular disease (e.g., statins) and multiple sclerosis (e.g., Fingolimod). Compared to traditional synthetic molecules, natural products have special structure and function, which brings advantages and challenges to the drug discovery process. Compared to synthetic compounds, natural products have higher skeleton diversity, structural complexity, and generally have higher molecular mass, more sp3 carbon atoms and oxygen atoms, more hydrogen bond acceptors and donors, and so on. Overall, natural product libraries cover a broader chemical space than typical synthetic small molecules. MCE provides a unique collection of 4,664 natural compounds that contain Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library is a useful tool for drug discovery that can be used for high-throughput screening (HTS) and high-content screening (HCS).

High-Throughput Natural Product Library

4,664 compounds

Natural products (NPs) are a class of widely bioactive compounds that have been shown to have a variety of uses, including pharmaceutical, agricultural, industrial and other fields. Historically, natural products have played a key role in drug discovery, particularly for cancer and infectious diseases, but also in other therapeutic areas, including cardiovascular disease (e.g., statins) and multiple sclerosis (e.g., Fingolimod). Compared to traditional synthetic molecules, natural products have special structure and function, which brings advantages and challenges to the drug discovery process. Compared to synthetic compounds, natural products have higher skeleton diversity, structural complexity, and generally have higher molecular mass, more sp3 carbon atoms and oxygen atoms, more hydrogen bond acceptors and donors, and so on. Overall, natural product libraries cover a broader chemical space than typical synthetic small molecules.

MCE provides a unique collection of 4,664 natural compounds that contain Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library is a useful tool for drug discovery that can be used for high-throughput screening (HTS) and high-content screening (HCS).

Cat. No.	Product Name	Chemical Structure

HY-11063S1

Fingolimod-d4 hydrochloride
Fingolimod-d₄ (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant[1].

HY-11063S

Fingolimod-d4
Fingolimod-d₄ is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant[1].

HY-143959S

Fingolimod Mono-lactate-d4 hydrochloride
Fingolimod Mono-lactate-d₄ (hydrochloride) is the deuterium labeled Fingolimod Mono-lactate hydrochloride[1].

HY-15381S

Fingolimod phosphate-d4
Fingolimod phosphate-d₄ is deuterium labeled FTY720 Phosphate.

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